A kind of composite microcapsule of oxymatrine and tributyrin and its preparation method and application

A technology of tributyrin and oxymatrine, applied in application, microcapsule, drug combination, etc., can solve problems such as harm to human health, lack of weaned piglets, antibiotic residues, etc.

Active Publication Date: 2022-03-29
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, my country's aquaculture industry still mainly uses antibiotics to reduce the incidence of weaned piglet diarrhea, so it will cause antibiotic residues in meat products, thereby endangering human health; and there is a lack of non-antibiotics that can effectively reduce the rate of weaned piglet diarrhea in the prior art veterinary medicine

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  • A kind of composite microcapsule of oxymatrine and tributyrin and its preparation method and application

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Embodiment 1

[0026] The preparation method of oxymatrine-tributyrin composite microcapsule A, the method comprises the steps:

[0027] Step 1, prepare the core material: Dissolve 1g of oxymatrine in 2mL of deionized water, then filter through a 0.22μm filter membrane, and then filter the filtered aqueous solution of oxymatrine and liquid tributyrin according to the volume ratio of 1:19 Mix and emulsify with a high shear emulsifier at 16 000 rpm for 10 min to obtain a core material. Among them, the mass ratio of oxymatrine to liquid tributyrin is 1:15.7.

[0028] Step 2, capsule material preparation: mix maltodextrin and sodium starch octenyl succinate with a mass ratio of 1:1, add to deionized water, and stir in a water bath at 60°C until dissolved to obtain maltodextrin and octenyl Starch sodium starch succinate total concentration (mass percentage concentration) is 30% aqueous solution, as capsule material.

[0029] Step 3, prepare the core capsule mixture: according to the mass ratio ...

Embodiment 2

[0032] The preparation method of oxymatrine-tributyrin composite microcapsule B comprises the following steps:

[0033] Step 1, prepare the core material: Dissolve 1 g of oxymatrine in 3 mL of deionized water, then filter it with a 0.22 μm filter membrane, and then make the filtered aqueous solution of oxymatrine and liquid tributyrin in a volume ratio of 1: 9 mixed and emulsified with a high shear emulsifier at 13,000 rpm for 15 minutes to obtain a core material. Among them, the mass ratio of oxymatrine to liquid tributyrin is 1:8.9.

[0034] Step 2, capsule material preparation: Add maltodextrin and sodium starch octenyl succinate with a mass ratio of 1:2 to deionized water, and stir in a water bath at 70°C until dissolved to obtain maltodextrin and octenyl starch The total concentration (mass percentage concentration) of starch sodium succinate is 20% aqueous solution, as the capsule material.

[0035] Step 3, prepare the core capsule mixture: according to the core materi...

Embodiment 3

[0038] The preparation method of oxymatrine-tributyrin composite microcapsule C, the method comprises the steps:

[0039] Step 1, prepare the core material: Dissolve 1g of oxymatrine in 4mL of deionized water, then filter it with a 0.22μm filter membrane, and then make the filtered aqueous solution of oxymatrine and liquid tributyrin in a volume ratio of 1: 4 Mix and emulsify for 20 minutes at 10,000 rpm with a high-shear emulsifier to obtain a core material. Among them, the mass ratio of oxymatrine to liquid tributyrin is 1:3.6.

[0040] Step 2, capsule material preparation: Add maltodextrin and sodium starch octenyl succinate with a mass ratio of 1:3 to deionized water, and stir in a water bath at 80°C until dissolved to obtain maltodextrin and octenyl starch The total concentration (mass percentage concentration) of starch sodium succinate is 25% aqueous solution, and the capsule material is obtained.

[0041] Step 3, prepare the core capsule mixture: according to the cor...

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Abstract

The invention provides a composite microcapsule of oxymatrine and tributyrin, a preparation method and application thereof, and belongs to the technical field of medicine preparation. The oxymatrine and tributyrin composite microcapsules include a core material and a capsule material, the core material includes oxymatrine and tributyrin, and the capsule material includes maltodextrin and octenyl Sodium starch succinate. The invention overcomes the discomfort of the mouthfeel of oxymatrine, and provides a composite microcapsule of oxymatrine and tributyrin, which has a synergistic effect in reducing the diarrhea rate of weaned piglets and can "replace resistance".

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a composite microcapsule of oxymatrine and tributyrin and its preparation method and application. Background technique [0002] Oxymatrine is the main component of traditional Chinese medicine Sophora flavescens, which has various pharmacological effects, such as anti-oxidation, anti-inflammation, antibacterial, anti-viral, anti-fibrosis, anti-tumor and neuroprotection. At present, oxymatrine is limited in its application in farming because of its bitter taste. [0003] Tributyrin, a short-chain fatty acid ester, has a slightly fatty aroma. It does not decompose in gastric juice, but is slowly released into butyric acid and glycerol under the action of enteropancreatic lipase, repairs small intestinal villi, inhibits harmful intestinal bacteria, and promotes the digestion, absorption and utilization of nutrients. [0004] At present, my country's aquacu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A23K50/30A23K50/60A23K20/158A23K20/163A23K20/137A23K40/30A61K9/52A61K47/36A61K47/14
CPCA23K50/30A23K50/60A23K20/158A23K20/163A23K20/137A23K40/30A61K9/5036A61K31/4375A61K47/14A61P1/12
Inventor 刘斐赵冬单衍可曹金虎金慧琴
Owner NANJING AGRICULTURAL UNIVERSITY
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