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Amidolignan compound in limonium latifolium root as well as preparation method and application thereof

A technology of lignans and compounds, which is applied in the field of phytochemistry, can solve the problems that have not yet been reported on the chemical constituents of eugenide lignans.

Active Publication Date: 2021-04-06
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After reviewing domestic and foreign literature, there has been no research report on the chemical constituents of eugenide lignans

Method used

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  • Amidolignan compound in limonium latifolium root as well as preparation method and application thereof
  • Amidolignan compound in limonium latifolium root as well as preparation method and application thereof
  • Amidolignan compound in limonium latifolium root as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] a. Get 20kg of dried blood-enriching grass roots and pulverize, according to the material-to-liquid ratio of 1:3, extract 1 time with anhydrous methanol at room temperature, and the time is 5 hours, and the extract is evaporated to dryness under reduced pressure with a rotary evaporator to obtain Extract;

[0087] b. Disperse the extract obtained in step a with water, use petroleum ether, ethyl acetate and n-butanol for extraction successively, obtain the extract of each polar section after concentrating under reduced pressure at a temperature of 40 ° C in a rotary evaporator, and then concentrate to paste , obtain petroleum ether position, ethyl acetate position and n-butanol position respectively;

[0088] c. Separate 120 g of the ethyl acetate fraction obtained in step b by normal phase silica gel column chromatography, and carry out gradient elution with chloroform-methanol in a volume ratio of 100:0-1:1 to obtain 15 fractions Fr.1-Fr .15;

[0089] d. Separate the...

Embodiment 2

[0096] a. Take 20kg of dried blood-enriching grass roots and pulverize, according to the material-to-liquid ratio of 1:5, extract 3 times by cold soaking at room temperature with concentration 70% ethanol, 2 hours each time, and evaporate the extract to dryness under reduced pressure with a rotary evaporator , to obtain an extract;

[0097] b. Disperse the extract obtained in step a with water, use petroleum ether, ethyl acetate and n-butanol for extraction successively, obtain the extract of each polar section after concentrating under reduced pressure at a temperature of 40 ° C by a rotary evaporator, and then concentrate to a paste shape, respectively obtain petroleum ether site, ethyl acetate site and n-butanol site;

[0098] c. Take 130 g of the ethyl acetate fraction obtained in step b and separate it by normal phase silica gel column chromatography, and carry out gradient elution with chloroform-methanol in a volume ratio of 100:0-1:1 to obtain 15 fractions Fr.1- Fr.15...

Embodiment 3

[0106] a. Get 20kg of dried blood-enriching grass roots and pulverize, according to the material-to-liquid ratio of 1:7, ultrasonically extract once at room temperature with a concentration of 80% ethanol for 10 hours, and the extract is evaporated to dryness under reduced pressure with a rotary evaporator to obtain Extract;

[0107] b. Disperse the extract obtained in step a with water, use petroleum ether, ethyl acetate and n-butanol for extraction successively, obtain the extract of each polar section after concentrating under reduced pressure at a temperature of 40 ° C by a rotary evaporator, and then concentrate to a paste shape, respectively obtain petroleum ether site, ethyl acetate site and n-butanol site;

[0108] c. Separate the ethyl acetate fraction obtained in step b by normal phase silica gel column chromatography, and carry out gradient elution with chloroform-methanol in a volume ratio of 100:0-1:1 to obtain 15 fractions Fr.1-Fr. 15;

[0109] d. Separate Fr.2...

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Abstract

The invention relates to an amidolignan compound in limonium latifolium root as well as a preparation method and application of the amidolignan compound. The method comprises the following steps: by taking limonium latifolium as a raw material, extracting by using a solvent, separating by using silica gel column chromatography, polyamide column chromatography and the like, and detecting and analyzing by using thin-layer chromatography, thereby obtaining 8 new amido lignan compounds and 10 known amido lignan compounds. It is found through hypoglycemic activity screening that the new amido lignan compound and the known amido lignan compound have different degrees of hypoglycemic activity and can be used for preparing hypoglycemic drugs, or the new amido lignan compound is combined with the hypoglycemic drugs to prepare hypoglycemic combined drugs or health care products.

Description

technical field [0001] The invention belongs to the field of phytochemistry, in particular to a large-leaf blood-enriching root amide lignan compound and a preparation method and application thereof. Background technique [0002] Limonium gmelinii (Limonium gmelinii) is a perennial herbal halophyte of the genus Limonium Mill. of the family Plumbaginaceae or Plumbaginaceae. It is mainly distributed in northern Xinjiang, and distributed in Yili, Tacheng and Altay regions. It is a traditional medicine for Uyghur and Kazakh people. The foreign research on Heliotrope is mainly performed by Professor G.E Zhusupova and L.M.Korulkina from the Faculty of Chemistry, Alfarabi State University, Kazakhstan, who isolated galactose, gallic acid, syringic acid, ellagic acid and several other species from the roots of the plant. Flavonoids and their glycosides. The roots contain a variety of flavonols. Dayebuxuecao has the functions of clearing heat and removing dampness, stopping bleedin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/78C07D209/66C07D207/28C07D319/20C07C235/48C07C231/24A61P3/10A23L33/105A23L33/10
CPCC07D311/78C07D209/66C07D207/28C07D319/20C07C235/48A61P3/10A23L33/105A23L33/10A23V2002/00A23V2200/328A23V2250/21Y02A50/30
Inventor 阿吉艾克拜尔·艾萨阿曼古力·托洪尔别克李俊
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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