Tannic acid cross-linked chitosan/gelatin liquid-absorbing hemostatic antibacterial sponge and preparation method thereof

A cross-linked chitosan, hemostasis and antibacterial technology, applied in the directions of pharmaceutical formulation, application, medical science, etc., can solve the problems of inability to provide the mechanical properties of hemostatic dressings, poor biocompatibility of acetalized sponges, and unfavorable wound healing, etc. Conducive to large-scale production, good market application prospects, and cheap market prices

Active Publication Date: 2021-04-13
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the liquid-absorbing hemostatic dressings used in clinical surgery usually include medical absorbent cotton or fiber, acetalized polyvinyl alcohol sponge and acetalized gelatin sponge, but the above-mentioned dressings There are usually the following disadvantages: medical absorbent cotton or fibers contain fiber filaments and fiber heads, which often affect the surgical field of vision due to fiber shedding during surgery, and are also not condu...

Method used

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  • Tannic acid cross-linked chitosan/gelatin liquid-absorbing hemostatic antibacterial sponge and preparation method thereof
  • Tannic acid cross-linked chitosan/gelatin liquid-absorbing hemostatic antibacterial sponge and preparation method thereof
  • Tannic acid cross-linked chitosan/gelatin liquid-absorbing hemostatic antibacterial sponge and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0043] A tannic acid cross-linked chitosan / gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof, specifically comprising the following steps:

[0044] S1, after dissolving 3g of chitosan with 22% acetic acid with a mass fraction, magnetically stir for 2h, and centrifuge to collect the supernatant; adjust the pH value of the collected supernatant to 9 with 0.5M NaOH, and place it statically to make the chitosan Completely precipitated, freeze-dried for 12 hours, obtained chitosan after purification, and set aside;

[0045] S2. Dissolve 8g of gelatin in acetic acid with a mass fraction of 20%, stir slowly, and heat to 60±0.5°C. After the gelatin is completely dissolved, add 2g of EDCI. After stirring for 15min, add chitosan and 2g of purified chitosan in step S1 at a time. DMAP, continuously stirred and heated for 6 hours to obtain a reaction solution;

[0046] S3. Dialyze the reaction solution obtained in step S2 with a semi-dialysis bag of...

Embodiment 2

[0052] A tannic acid cross-linked chitosan / gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof, specifically comprising the following steps:

[0053] S1, after dissolving 3g of chitosan with 22% acetic acid with a mass fraction, magnetically stir for 2h, and centrifuge to collect the supernatant; adjust the pH value of the collected supernatant to 9 with 0.5M NaOH, and place it statically to make the chitosan Completely precipitated, freeze-dried for 12 hours, obtained chitosan after purification, and set aside;

[0054] S2. Dissolve 8g of gelatin in acetic acid with a mass fraction of 20%, stir slowly, and heat to 60±0.5°C. After the gelatin is completely dissolved, add 2g of EDCI. After stirring for 15min, add chitosan and 2g of purified chitosan in step S1 at a time. DMAP, continuously stirred and heated for 6 hours to obtain a reaction solution;

[0055] S3. Dialyze the reaction solution obtained in step S2 with a semi-dialysis bag of...

Embodiment 3

[0061] A tannic acid cross-linked chitosan / gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof, specifically comprising the following steps:

[0062] S1, after dissolving 3g of chitosan with 22% acetic acid with a mass fraction, magnetically stir for 2h, and centrifuge to collect the supernatant; adjust the pH value of the collected supernatant to 9 with 0.5M NaOH, and place it statically to make the chitosan Completely precipitated, freeze-dried for 12 hours, obtained chitosan after purification, and set aside;

[0063] S2. Dissolve 8g of gelatin in acetic acid with a mass fraction of 20%, stir slowly, and heat to 60±0.5°C. After the gelatin is completely dissolved, add 2g of EDCI. After stirring for 15min, add chitosan and 2g of purified chitosan in step S1 at a time. DMAP, continuously stirred and heated for 6 hours to obtain a reaction solution;

[0064] S3. Dialyze the reaction solution obtained in step S2 with a semi-dialysis bag of...

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Abstract

The invention belongs to the technical field of functional materials, and discloses tannic acid cross-linked chitosan gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof. The preparation method comprises the steps: carrying out chemical cross-linking on chitosan and gelatin through an esterification reaction to form a primary cross-linking network, and thus obtaining modified super-hydrophilic gelatin; taking tannic acid as a cross-linking agent, and further cross-linking under the action of a strong oxidant to form a secondary cross-linked network; and then adding medical auxiliary materials, hydroxyapatite and sodium alginate to carry out physical mechanical foaming, and carrying out freeze drying to obtain the porous spongy chitosan/gelatin liquid-absorbing hemostatic antibacterial sponge. The spongy porous material obtained by crosslinking tannic acid with chitosan/gelatin is good in mechanical property, porous and fine in structure, soft in surface, wide in raw material source, low in market price, good in biocompatibility, non-toxic and biodegradable, and does not need to be infiltrated in advance when being in contact with a human body; and the preparation method is simple and efficient, is beneficial to large-scale production and has a good market application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a tannic acid cross-linked chitosan gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof. Background technique [0002] At present, the liquid-absorbing hemostatic dressings used in clinical surgery usually include medical absorbent cotton or fiber, acetalized polyvinyl alcohol sponge and acetalized gelatin sponge, but the above-mentioned dressings usually have the following disadvantages: medical absorbent cotton or fiber contains fiber filaments and fiber heads , the surgical field of view is often affected due to fiber shedding during surgery, and it is not conducive to wound healing; the biocompatibility of acetalized sponge is poor, and the aldehyde crosslinking agents such as glutaraldehyde and formaldehyde used in the manufacturing process have a large Biological toxicity, easy to residue, serious environmental ...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08J9/30C08J9/00C08J3/24C08L89/00C08L5/08C08L5/04A61L24/00A61L24/02A61L24/08A61L24/10A61L26/00
CPCC08J9/28C08J9/30C08J9/0061C08J9/0095C08J3/24A61L26/0038A61L26/0023A61L26/0085A61L26/0004A61L26/0066A61L26/009A61L24/0036A61L24/0015A61L24/104A61L24/08A61L24/02A61L24/0042C08J2389/00C08J2405/08C08J2405/04C08J2201/0484C08J2205/06A61L2400/04A61L2300/102A61L2300/254A61L2300/428A61L2300/404A61L2300/418C08L89/00C08L5/08C08L5/04
Inventor 林祥松姜暘沈建祥李雪陈洪旭
Owner JIAXING UNIV
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