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Application of 7-aldehyde group-9-isobutyryloxy-8-hydroxythymol in preparing antibacterial agent or antibacterial drug

A technology of isobutyryloxy and hydroxythymol, applied in the preparation of antibacterial agents or antibacterial drugs, in the field of 7-formyl-9-isobutyryloxy-8-hydroxythymol, can solve the problem of Questions to be explored

Active Publication Date: 2021-10-12
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on this plant shows that the phytochemical components are very rich, but the research on the antibacterial active chemical components of this plant still needs to be further studied

Method used

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  • Application of 7-aldehyde group-9-isobutyryloxy-8-hydroxythymol in preparing antibacterial agent or antibacterial drug
  • Application of 7-aldehyde group-9-isobutyryloxy-8-hydroxythymol in preparing antibacterial agent or antibacterial drug
  • Application of 7-aldehyde group-9-isobutyryloxy-8-hydroxythymol in preparing antibacterial agent or antibacterial drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation of 7-formyl-9-isobutyryloxy-8-hydroxythymol in Eupatorium adenophorum

[0021] 1.1 Plant source and identification

[0022] A sample of the aerial part of the plant material Ageratina adenophora (Ageratina adenophora) used for extraction was collected from the suburbs of Kunming, Yunnan in July 2009, and was identified by the inventor, Dr. Tan Jianwen.

[0023] 1.2 Extraction and separation

[0024] Naturally air-dried and crushed Eupatorium adenophorum aerial parts (5kg) were used as raw materials, soaked and extracted with 95% ethanol water at room temperature for 3 times (3×10L, 24h each time). Then the ethanol extracts were combined and concentrated under reduced pressure to remove ethanol, then added an appropriate amount of water to suspend in water, extracted with petroleum ether (3×2 L), and concentrated under reduced pressure to obtain the petroleum extract (46.5 g).

[0025] The obtained petroleum ether extraction part is subjected to ...

Embodiment 2

[0033]Example 2: Detection of antibacterial activity of compound 7-formyl-9-isobutyryloxy-8-hydroxythymol

[0034] 3.1 Types of bacteria used in experiments

[0035] Gram-positive bacteria: Staphyloccocus aureus, Bacillus cereus, Bacillus thuringiensis;

[0036] Gram-negative bacteria: Escherichia coli, Salmonella enterica.

[0037] 3.2 Experimental drugs

[0038] Positive control substance: kanamycin sulfate (kanamincy sulfate)

[0039] Negative control: MeOH

[0040] Test compound: the new compound 7-formyl-9-isobutyryloxy-8-hydroxy thymol of the present invention (i.e. the following compound 1) is prepared from the above experimental examples, and two other thymols with similar structures Compound 7,9-diisobutyryloxy-8,10-dehydrothymol (ie compound 2) and 7,9-diisobutyryloxy-8-methoxythymol (ie Compound 3) is used as an active comparison reference substance for similar compounds, and the structures of compounds 1-3 are shown in the figure below:

[0041]

[0042] 3...

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PUM

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Abstract

The invention discloses a 7-formyl-9-isobutyryloxy-8-hydroxy thymol and its application in the preparation of antibacterial agents or antibacterial drugs. The invention extracts and isolates 7-formyl-9-isobutyryloxy-8-hydroxy thymol which has effective inhibitory effect on both Gram-positive bacteria and Gram-negative bacteria from Eupatorium adenophorum plants. Eupatorium adenophorum plant materials are rich in sources, easy to extract and prepare, and using the invasive plant Eupatorium adenophorum as raw material for extraction can also promote the use of this invasive plant to turn waste into treasure, and it is expected to obtain economic benefits while indirectly It has a positive effect on the prevention and control of Eupatorium adenophorum, and the compound from natural sources is stable and easy to store. The compound 7-formyl-9-isobutyryloxy-8-hydroxythymol has significant antibacterial activity, and it is very likely to be developed into an effective and safe new antibacterial agent or a new drug for treating bacterial infection diseases, with potential good prospects.

Description

Technical field: [0001] The invention belongs to the field of antibacterial, antiseptic and medical technology, and in particular relates to a novel thymol derivative compound, i.e. 7-formyl-9-isobutyryloxy-8-hydroxy thymol, and relates to the preparation of the new compound Method, and the application of the compound in the preparation of antibacterial agents or antibacterial drugs. Background technique: [0002] Pathogenic bacteria are an important source of human infectious diseases, and pathogenic bacteria are gradually accumulating resistance to existing antibacterial drugs or antibacterial preparations on the market, which is posing an increasingly significant threat to people's health. Promoting research and development of new There is an increasingly realistic and important demand for antibacterial drugs or antibacterial agents for the prevention and treatment of bacterial infection diseases. [0003] Eupatorium adenophorum is an invasive alien plant with a huge amo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/30C07C67/56C07C67/58A61K31/222A61P31/04
CPCY02A50/30
Inventor 谭建文徐巧林刘少博钱涛
Owner SOUTH CHINA AGRI UNIV
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