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Application of 1-phenyl-1-propanol in preparation of medicine for treating hyperlipidemia and/or diabetes

A diabetes drug and hyperlipidemia technology, applied in the field of medicine, can solve the problems of aggravating ulcer disease, increasing blood uric acid, reducing glucose tolerance, etc., and achieving the effects of less toxic and side effects, lowering triglyceride and blood sugar, and lowering concentration

Active Publication Date: 2022-03-18
HUAZHONG AGRICULTURAL UNIVERSITY
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nicotinic acid drugs can reduce blood lipid and blood sugar, but there are serious side effects. The use of hydrochloric acid drugs may activate peptic ulcer, aggravate ulcer disease, reduce the body's glucose tolerance, and aggravate diabetes. May increase blood uric acid and even cause gout

Method used

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  • Application of 1-phenyl-1-propanol in preparation of medicine for treating hyperlipidemia and/or diabetes
  • Application of 1-phenyl-1-propanol in preparation of medicine for treating hyperlipidemia and/or diabetes
  • Application of 1-phenyl-1-propanol in preparation of medicine for treating hyperlipidemia and/or diabetes

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Experimental program
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Effect test

Embodiment 1

[0026] 1. Experimental animals and feed

[0027] As experimental animals, 3-week-old C57BL / 6J mice, all male, were purchased from the Experimental Animal Center of Huazhong Agricultural University.

[0028] Ordinary feed consists of basal feed, and high-fat feed is made by mixing 73.8% of basal feed with 15% egg yolk powder, 10% lard, 1% cholesterol and 0.2% sodium cholate. The nutritional index is 21.46% of crude protein, 22.75% of crude fat, 2.68% of crude fiber, 1.32% of calcium, 0.88% of phosphorus, and the ratio of calcium: phosphorus is 1.5:1. High-fat feed and normal feed were purchased from the Experimental Animal Center of Huazhong Agricultural University.

[0029] 2. Experimental method

[0030] The 3-week-old C57BL / 6J mice were randomly divided into normal diet group and high-fat diet group (control group) according to body weight. After 6 weeks of high-fat feeding, blood was taken from the tail vein to detect whether the obese mouse model in the high-fat diet gr...

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Abstract

The invention provides the application of 1-phenyl-1-propanol in the preparation of medicines for treating hyperlipidemia and / or diabetes, and belongs to the field of medicine. The medicine for treating hyperlipidemia and / or diabetes prepared by the 1-phenyl-1-propanol provided by the present invention has good effects of lowering blood fat and blood sugar, meanwhile, it has little toxic and side effects on the liver, and no adverse reaction occurs; and because It is cheap, slightly fragrant, and has a spicy and sweet taste. It can be used as a health product or food additive in production and life in the future to improve the health of the people. The results of the embodiments show that 1-phenyl-1-propanol can simultaneously reduce the effects of triglycerides, blood sugar and aspartate aminotransferase in the blood plasma of high-fat diet mice; meanwhile, generate bile acid and primary bile to cholesterol The metabolic pathway of acid conversion into secondary bile acids has no obvious effect, and the effect of lowering blood fat and blood sugar is mainly achieved by specifically increasing the content of plasma glycine-binding bile acids.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of 1-phenyl-1-propanol in the preparation of medicines for treating hyperlipidemia and / or diabetes. Background technique [0002] High-fat, low-carbohydrate diets are gradually becoming popular, followed by an increase in the rate of overweight and obesity year by year, as well as an increase in patients with hyperlipidemia, cardiovascular disease, diabetes and other diseases. Hyperlipidemia mainly includes hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia. It has been proven that hyperlipidemia is a major risk factor for cardiovascular and cerebrovascular diseases such as atherosclerosis and myocardial infarction. [0003] At the same time, studies have shown that patients with hyperlipidemia often have other complications, such as type 2 diabetes (Yang Jinkui et al., 2002). In clinical manifestations, patients with hyperlipidemia usually h...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P3/06A61P3/10A23L33/10
CPCA61K31/045A61P3/06A61P3/10A23L33/10A23V2002/00A23V2200/326A23V2200/328A23V2250/08
Inventor 张利生朱可玮
Owner HUAZHONG AGRICULTURAL UNIVERSITY
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