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Sustained-release film for preventing prefrontal alopecia and preparation method thereof

A slow-release film and pre-release technology, which is applied in the field of slow-release film and its preparation, can solve the problems of rapid volatilization, loss, and long-term interaction with the skin, so as to promote drug absorption, improve therapeutic effect, and avoid odor emission. Effect

Active Publication Date: 2021-04-23
深圳新发源植物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There are a lot of water-soluble ingredients such as tea polyphenols, vitamin H, aloe extract, vitamin B complex, cysteine, and Polygonum multiflorum extract in its ingredients. At the same time, there are also oil-soluble substances such as linoleic acid. Ethanol is used as a solvent, and corn gluten amino acids are used as an emulsifier to blend all the ingredients together. The finished product is an emulsion, and the vitamin B complex, Polygonum multiflorum extract, Angelica extract and other ingredients have darker colors. Users usually only It can be used at home, but the drug ingredients need to interact with the skin for a long time to achieve a good effect, so it will affect the normal life of the user. volatilization and loss

Method used

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  • Sustained-release film for preventing prefrontal alopecia and preparation method thereof

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preparation example Construction

[0030] The preparation method of sustained-release film 2 is as follows:

[0031] S1. Disperse 1 g of chitosan in 30 ml of water, add 10 ml of acetic acid with a concentration of 1 mol / L and mix evenly, then add sodium bicarbonate solution to adjust the pH to 5-5.6 (optimally 5.52) to obtain a dispersion.

[0032] S2. In parts by mass, mix 1 part of Poria cocos polysaccharide, 2 to 4 parts of Sapindus chinensis extract, 1 to 8 parts of Lentinus edodes mycelia extract, 0.2 to 2 parts of evening primrose oil, 2 to 5 parts of motherwort extract, 0.1 ~3 parts of vitamin E and 0.1~1 part of tea tree essential oil are evenly mixed to obtain a mixture.

[0033] S3. Add cyclodextrin into water and sonicate until dissolved. According to the mass ratio of the mixture and cyclodextrin at 1:15-40, add the mixture into the solution and sonicate for 1-4 hours, and store it at a temperature of 0-2°C for 5 ~6h, filter, dry, and pulverize to obtain the drug-cyclodextrin.

[0034]S4. Add gluc...

Embodiment 1

[0049] S1. Preparation of sustained-release film 2: Disperse 1 g of chitosan in 30 ml of water, add 10 ml of acetic acid with a concentration of 1 mol / L and mix well, then add sodium bicarbonate solution to adjust the pH to 5 to obtain a dispersion.

[0050] In parts by mass, mix 1 part of pachyrhiza, 2 parts of sapindus chinensis extract, 1 part of shiitake mushroom mycelium extract, 0.2 part of evening primrose oil, 2 parts of motherwort extract, 0.1 part of vitamin E and 0.1 part of tea tree essential oil , to obtain a mixture.

[0051] Add cyclodextrin into water and sonicate until dissolved. According to the mass ratio of mixture and cyclodextrin at 1:15, add the mixture to the solution and sonicate for 1 hour, store it at 2°C for 6 hours, filter, dry, and pulverize to obtain the drug - Cyclodextrins.

[0052] Add glucoamylase and drug-cyclodextrin to the dispersion to obtain a film-forming solution, pour the film-forming solution into a plate, dry at a temperature of 30...

Embodiment 2

[0056] S1. Preparation of sustained-release film 2: Disperse 1 g of chitosan in 30 ml of water, add 10 ml of acetic acid with a concentration of 1 mol / L and mix well, then add sodium bicarbonate solution to adjust the pH to 5.6 to obtain a dispersion.

[0057] In parts by mass, mix 1 part of Poria cocos polysaccharide, 4 parts of Sapindus chinensis extract, 8 parts of shiitake mushroom mycelia extract, 2 parts of evening primrose oil, 5 parts of motherwort extract, 3 parts of vitamin E and 1 part of tea tree essential oil , to obtain a mixture.

[0058] Add cyclodextrin into water and sonicate until dissolved. According to the mass ratio of the mixture and cyclodextrin at 1:40, add the mixture to the solution and sonicate for 4 hours, store it at 0°C for 6 hours, filter, dry, and pulverize to obtain the drug - Cyclodextrins.

[0059] Add glucoamylase and drug-cyclodextrin to the dispersion to obtain a film-forming solution, pour the film-forming solution into a plate, dry at ...

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Abstract

The invention discloses a sustained-release film for preventing prefrontal alopecia and a preparation method thereof and relates to the field of hair care. The sustained-release film comprises a first protective layer, a sustained-release film, a gel layer, a chroma layer and a second protective layer which are arranged in sequence; the chroma layer comprises an extension edge, and the extension edge is used for being attached to the exterior of affected skin of a patient; the color of the chroma layer is set according to the skin color; the thickness of the sustained-release film is 1-3 microns; the thickness of the chroma layer is 1-5 nanometers; and the gel layer is formed by a cavity structure formed by coating the sustained-release film and the chroma layer. The normal life of a user can be prevented from being influenced, and the effectiveness of the medicine can be improved.

Description

technical field [0001] The invention relates to the field of hair care, in particular to a slow-release film for preventing forehead hair loss and a preparation method thereof. Background technique [0002] In daily life, the number of people with hair loss is increasing rapidly. In addition to the excessive secretion of male hormones caused by genetic factors, the pollution of smog, noise and smoke in the environment is relatively high, the damage of dyeing and perming, and the pressure in work and life will all lead to mental state. Poor, low sleep quality, which can cause endocrine disorders, fungal infection or poor microcirculation, leading to hair loss. [0003] At present, drugs such as oral cyproterone, megestrol ketone, and megestrol are mainly used to suppress the hair loss caused by excessive androgen secretion, but these drugs have strong side effects; For hair loss caused by genetic reasons, you can choose to use functional shampoo drugs or traditional Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/70A61K47/69A61K47/38A61K47/42A61K47/36A61P17/14B32B9/04B32B33/00A61K36/896A61K36/886A61K31/715A61K31/355A61K31/7048
Inventor 彭文彪常汝伟
Owner 深圳新发源植物科技发展有限公司
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