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Antibacterial polyethylene composite material for contraceptive device and preparation method and application thereof

A technology of composite materials and polyethylene, applied in medical science, surgery, etc., can solve the problems of reducing the mechanical properties of composite materials, achieve the effects of improving chemical stability, ensuring flexibility, and mild reaction conditions

Active Publication Date: 2021-04-30
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan-copper complex composites are easily degraded in the environment of the human uterus for a long time, resulting in the "violent release" of copper ions and reducing the mechanical properties of the composites

Method used

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  • Antibacterial polyethylene composite material for contraceptive device and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Prepare a kind of antibacterial polyethylene composite material for birth control devices, comprising the steps of:

[0049] Prepare copper-containing slow-release material: prepare a polyglutamic acid solution with a concentration of 1%, add chitosan that is 2 times the quality of polyglutamic acid, adjust the pH of the solution to about 3.5 with glacial acetic acid, and stir until the chitosan Dissolve, then add 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride with the same quality as polyglutamic acid, stir at room temperature, cross-linking reaction for 24h, then add chitosan, etc. Quality copper sulfate, complexation reaction 2h, adjust solution pH to 6.6 with 0.1M sodium hydroxide solution, precipitate insoluble matter (macromolecular polybasic acid cross-linked chitosan and the complex formed by copper ion), after centrifugal precipitation The insoluble matter is fully washed with deionized water, and the insoluble matter is collected by centrifugation,...

Embodiment 2

[0053] Preparation of copper-containing slow-release material: an antibacterial polyethylene composite material for an IUD, comprising the following steps:

[0054] Prepare and prepare the polyaspartic acid solution that concentration is 0.1%, add the chitosan of 5 times of polyaspartic acid quality, adjust solution pH with glacial acetic acid to be about 3.5, stir chitosan to dissolve, then add and polytian The 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride of aspartic acid equal quality, stir at room temperature, cross-linking reaction 12h, then add the copper sulfate of 0.5 times chitosan quality, complex Combined reaction for 4 hours, adjust the pH of the solution to 5.6 with 0.2M sodium hydroxide solution, precipitate insoluble matter, and then use deionized water to fully wash the insoluble matter after centrifugation, then collect the insoluble matter by centrifugation, dry, and ball mill to obtain copper-containing slow-release Material.

[0055] Melt blen...

Embodiment 3

[0058] Prepare a kind of antibacterial polyethylene composite material for birth control devices, comprising the steps of:

[0059] Preparation of copper-containing slow-release material: prepare a polyacrylic acid solution with a concentration of 2%, add chitosan with the same quality as polyacrylic acid, adjust the pH of the solution to about 3.5 with glacial acetic acid, stir to dissolve the chitosan, and then add 2 times polyacrylic acid Acrylic acid mass of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, stirring at room temperature, crosslinking reaction for 18 hours, then adding 0.4 times the mass of chitosan copper sulfate, complexation reaction for 6 hours , adjust the pH of the solution to 4.5 with 0.1M sodium hydroxide solution, precipitate insoluble matter, and then wash the insoluble matter thoroughly with deionized water after centrifugal precipitation, then collect the insoluble matter by centrifugation, dry, and ball mill to obtain a copper-containin...

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Abstract

The invention discloses an antibacterial polyethylene composite material for a contraceptive device and a preparation method thereof. The antibacterial polyethylene composite material comprises the following components in parts by weight: 70-90 parts of polyethylene; 0.5-5 part of a copper-containing slow release material; 5-29 parts of an inorganic filler; and 0.01-1 part of an antioxidant. According to the antibacterial polyethylene composite material for the contraceptive device, carboxyl in macromolecule polybasic acid reacts with amino of chitosan, chitosan molecular chains are cross-linked through covalent bonds, copper ions are introduced to form a carboxyl and amino binary complex copper ion structure, the structural stability is high, the release rate of the copper ions is reduced, the guarantee is provided for the slow release of copper ions, and thus the chemical stability and the biocompatibility of the composite material are improved.

Description

technical field [0001] The invention relates to the field of antibacterial composite materials, in particular to an antibacterial polyethylene composite material for birth control devices and its preparation method and application. Background technique [0002] The intrauterine device (IUD) has been used clinically for nearly a century as a safe, effective and reversible method of contraception. In the early days, IUDs were mainly made of inert materials, such as plastic, rubber, stainless steel, etc. With the development of technology and the continuous improvement of clinical cognition, the current IUDs are mainly based on active materials, that is, polymer scaffolds planted with copper or drug-loaded IUDs, which achieve contraception by releasing copper ions or releasing drugs in the uterus. The IUD currently used in my country is mainly based on the IUD containing copper, such as T Cu IUD: take polyethylene as the T-shaped support, and copper wire or copper ring are wou...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14A61L31/16C08B37/08
CPCA61L31/128A61L31/16A61L31/14A61L31/148C08B37/003A61L2300/102A61L2300/404A61L2300/602C08L29/04C08L5/08
Inventor 张维刘军刘可马楠朱琼琼
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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