Amide derivative neutral mitochondria fluorescent markers as well as preparation method and application thereof

A technology of amide derivatives and fluorescent markers, applied in the field of fluorescent markers
CN112778258AActive Publication Date: 2021-05-11SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2021-05-11

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Abstract

The invention relates to a series of amide derivative neutral mitochondrial fluorescent markers as well as a preparation method and application thereof. The invention discloses excellent mitochondrial targeting ability after a neutral dye is connected with an amide compound for the first time. The problems that the organelle targeting capacity of existing neutral structure fluorescent dye is uncertain, and neutral dye is a commercial marker of lipid droplets in cells are solved. While the optical performance of the fluorescent dye is improved, the organelle targeting ability of the original dye is regulated and controlled by creatively modifying the structure of the fluorescent dye, and the biological performance of the dye is obviously improved after the fluorescent dye is connected with an amide compound. The amide compound is cheap and easy to obtain, is beneficial to control of the cost of the new dye, and has great scientific significance and commercial value.
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Description

technical field

[0001] The invention relates to fluorescent marker technology, in particular to an amide derivative neutral mitochondrial fluorescent marker and its preparation method and application. Background technique

[0002] Mitochondria is an organelle surrounded by two membranes that exists in most cells. It is a structure that produces energy in cells and is the main place for cells to carry out aerobic respiration. In addition to serving as the main place for aerobic respiration and providing energy for cells, it also participates in important physiological activities such as cell genetic material transfer and cell differentiation, and has the ability to regulate cell growth and cell cycle. Therefore, in scientific research, real-time monitoring of mitochondria is particularly important. Among various technical means, fluorescent labeling technology stands out because of its advantages of simple operation and low preparation cost. Various fluorescent probes and d...

Claims

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