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Nano polysaccharide compound and preparation method and application thereof

A compound and polysaccharide technology, applied in the fields of drug delivery, pharmaceutical formulation, medical science, etc., can solve the problems of high energy consumption, time-consuming and labor-intensive, and inability to provide physical and chemical properties at the same time.

Inactive Publication Date: 2021-05-18
PANION & BF BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general fabrication methods of nanoscale biomaterials are time-consuming, labor-intensive, energy-intensive, or cannot provide suitable physical and chemical properties at the same time.

Method used

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  • Nano polysaccharide compound and preparation method and application thereof
  • Nano polysaccharide compound and preparation method and application thereof
  • Nano polysaccharide compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0053] Take 50g of Ganoderma tsugae (Ganoderma tsugae) fiber extracted by hot water (purchased from Kang Jian, Nantou, Taiwan, China), and decompose it with 400mL of 1N sodium hydroxide at 85°C for 24 hours. After decomposition, the reaction residue was collected and washed with deionized water to remove residual sodium hydroxide. Then use hydrogen peroxide (the weight ratio of hydrogen peroxide and reaction residue is 1:3) to decolorize to obtain a syrupy mixture. After decolorization (bleaching), the decolorized slurry mixture is thoroughly washed with secondary deionized water. The polysaccharide complex (SC) referred to in this disclosure is obtained by filtering and freeze-drying the cleaned slurry mixture.

[0054] The nanometerization of the polysaccharide complex includes physical methods and chemical methods, and in Preparation Example 1, the physical method of nanometerization will be described as follows. Disperse 4 g of the polysaccharide complex in 200 mL of sec...

preparation example 2

[0056] The difference from Preparation Example 1 is that in Preparation Example 2, after the step of collecting the polysaccharide complex, the nano-polysaccharide complex will be produced by chemical oxidation. Specifically, the chemical method in Preparation Example 2 was performed by an oxidation system with TEMPO.

[0057] 5 g of the polysaccharide complex was dispersed in 375 mL of secondary deionized water containing 0.0625 g of TEMPO and 0.625 g of sodium bromide to obtain a mixed solution. The TEMPO-mediated oxidation of the mixed solution (slurry) with polysaccharide complexes will be initiated after adding 5% sodium hypochlorite (NaClO) aqueous solution. There are 5 kinds of NaClO addition amounts (1.66, 3.33, 5.00, 6.67 and 10 mmol NaClO per gram of polysaccharide complex, respectively), and then add the aforementioned 5 kinds of NaClO addition amounts to the mixed solution, and keep stirring at room temperature. During the reaction, 5N sodium hydroxide and 1N hydr...

Embodiment 1

[0061] For the various properties and detection data of the above nano-polysaccharide complexes, please refer Figure 1A to Figure 1E . Regarding the code, SC in the figure represents the polysaccharide complex; SCN3 represents the nano-polysaccharide compound made by 3 cycles through the high-pressure homogenizer; SCN5 represents the nano-polysaccharide compound made by 5 cycles through the high-pressure homogenizer ; CN10 represents the nano-polysaccharide compound made by carrying out 10 cycles through a high-pressure homogenizer; T016SC represents the nano-polysaccharide compound made by oxidation of 1.66 mmol NaClO per gram of polysaccharide compound; Nano-polysaccharide complexes made by oxidation of mmol NaClO; T050SC represents nano-polysaccharide complexes produced by oxidation of 5.0 mmol NaClO per gram of polysaccharide complexes; T067SC represents nano-polysaccharide complexes produced by oxidation of 6.67 mmol NaClO per gram of polysaccharide complexes Polysaccha...

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PUM

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Abstract

The invention provides a nano polysaccharide compound and a preparation method and application thereof, and the nano polysaccharide compound comprises beta-1, 3-glucan and chitin, wherein the nano polysaccharide compound has a spectrum of solid carbon-13 cross polarization magic angle rotation nuclear magnetic resonance, and the spectrum comprises the following peak values: 176 + / -0.2 ppm, 103 + / -0.2 ppm, 87 + / -0.2 ppm and 74 + / -0.2 ppm. The nano polysaccharide compound has the effects of promoting wound healing, treating xerophthalmia and promoting bone regeneration.

Description

technical field [0001] The present disclosure is about a nano-polysaccharide complex and its manufacturing method and use, especially about the nano-polysaccharide complex for promoting wound healing, treating dry eye or bone reconstruction, its manufacturing method and its use. Background technique [0002] When developing biomaterials, safety is a primary consideration. An ideal biomaterial should be biocompatible with the host and have three properties. First, biomaterials must be biochemically compatible with the host's physiological systems and must be nontoxic, non-rejection-causing, non-allergenic, and non-carcinogenic. Second, biomaterials must be biochemically compatible with surrounding tissues. Third, there should be proper bioadhesive contact between the biomaterial and the living tissue. [0003] According to the material type, we can classify biomaterials into four types: metals, ceramics, polymers, and composites. Polymers, especially biopolymers, have att...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/36A61L27/50A61L27/52A61L27/56A61L27/60
CPCA61L27/26A61L27/3616A61L27/52A61L27/56A61L27/60A61L27/50A61L2400/12A61L2430/02A61L2430/16
Inventor 许明照
Owner PANION & BF BIOTECH INC
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