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A pharmaceutical composition, solid oral preparation and application thereof for treating hypertension

A technology of oral preparations and compositions, applied in the field of drugs for the treatment of hypertension, which can solve the problems that patients need long-term or even life-long medication and cannot be cured, and achieve the effects of strong synergistic effect, weakened antihypertensive effect, and prevention of complications

Active Publication Date: 2022-02-01
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because antihypertensive drugs do not treat the cause, although high blood pressure can be controlled, it cannot be cured. Therefore, long-term or even life-long medication is required for most patients.

Method used

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  • A pharmaceutical composition, solid oral preparation and application thereof for treating hypertension
  • A pharmaceutical composition, solid oral preparation and application thereof for treating hypertension
  • A pharmaceutical composition, solid oral preparation and application thereof for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A compound tablet for the treatment of hypertension, the formula is composed as follows: 48g of Aliskiren, 12g of geniposide, 200g of dextrin, 25g of sodium carboxymethyl starch, 10g of micropowder silica gel, appropriate amount of starch slurry, made into 1000 piece.

[0025] Preparation method: weigh Aliskiren and geniposidic acid according to the formula, use dextrin as filler, sodium carboxymethyl starch as disintegrant, micronized silica gel as lubricant, and starch slurry as binder , using a fluidized bed to granulate and tablet, to obtain.

Embodiment 2

[0027] A compound tablet for treating high blood pressure, the formula is composed as follows: Aliskiren 40g, geniposide 20g, microcrystalline cellulose 200g, low-substituted hydroxypropyl cellulose 25g, hydrogenated vegetable oil 10g, 20% polysaccharide Proper amount of vinyl alcohol solution, made into 1000 tablets.

[0028] Preparation method: weigh Aliskiren and geniposidic acid according to the formula, use microcrystalline cellulose as filler, low-substituted hydroxypropyl cellulose as disintegrant, hydrogenated vegetable oil as lubricant, and 20% The polyvinyl alcohol solution is used as a binder, and a fluidized bed is used for granulation and tabletting to obtain the product.

Embodiment 3

[0030] A compound tablet for treating high blood pressure, the formula is composed as follows: Aliskiren 45g, geniposide 15g, lactose 200g, cross-linked polyvinylpyrrolidone 25g, talcum powder 10g, 10% polyethylene glycol 4000 solution Appropriate amount, made into 1000 pieces.

[0031] Preparation method: weigh Aliskiren and geniposidic acid according to the formula, use lactose as filler, cross-linked polyvinylpyrrolidone as disintegrant, talcum powder as lubricant, and 10% polyethylene glycol 4000 The solution is used as a binder, and the fluidized bed is used for granulation and tabletting to obtain the product.

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PUM

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Abstract

The invention relates to the field of drugs for treating hypertension, in particular to a pharmaceutical composition for treating hypertension, a solid oral preparation and applications thereof. The pharmaceutical composition of the present invention contains aliskiren and geniposide as active ingredients, and the weight ratio between the two is 2-4:1. The present invention proves that the combined use of aliskiren and geniposidic acid in a specific ratio can achieve a synergistic effect in lowering blood pressure. The combined use of aliskiren and geniposidic acid is of great significance for the clinical treatment of hypertension. It can effectively prevent various complications in patients with hypertension, and can reduce the adverse reactions of aliskiren while enhancing the curative effect, such as Diarrhea, indigestion and headache etc.

Description

technical field [0001] The invention relates to the field of drugs for treating hypertension, in particular to a pharmaceutical composition for treating hypertension, a solid oral preparation and applications thereof. Background technique [0002] Hypertension refers to elevated arterial systolic or diastolic blood pressure (≥140 / 90mmHg) at rest, often accompanied by disorders of fat and glucose metabolism and functional or organic changes in the heart, brain, kidney, retina and other organs , a systemic disorder characterized by organ remodeling. Resting for more than 5 minutes, blood pressure ≥ 140 / 90mmHg measured more than 2 times on different days can be diagnosed as hypertension. Because its pathological damage can lead to atherosclerosis, which can cause stroke, occlusive cardiovascular disease (such as coronary atherosclerotic heart disease, etc.) One of the causes of death and disability. In recent years, the prevalence of hypertension in my country has increased ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/20A61P9/12A61K31/165
CPCA61K31/165A61K31/7048A61K9/2059A61K9/2054A61K9/2027A61P9/12A61K2300/00
Inventor 董天崴武冬梅王敬磊郭英雪李锦莲
Owner JIAMUSI UNIVERSITY