New application of sevelamer

A technology of Sevelamer and Sevelamer, which is applied in the field of medicine, can solve the problems of short retention time and large system toxicity, and achieve the effect of prolonging the survival period and high survival rate
CN112957368APending Publication Date: 2021-06-15NANCHANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANCHANG UNIV
Publication Date
2021-06-15

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Abstract

The invention relates to the technical field of medicines, in particular to a novel application of sevelamer. The sevelamer is used as an active component, the sevelamer is prepared into a sevelamer injection, and the sevelamer injection is combined with transcatheter arterial embolization to treat liver cancer. Granules obtained after sevelamer is subjected to ball milling serve as a tumor blood supply artery embolization agent instead of traditional iodophol or polymer-based drug-loaded microspheres, so that tumor oxygen supply is blocked, inorganic phosphorus in the tumor environment is deprived, complete tumor necrosis is caused, residual active tumor tissue is not found, and the tumor blood supply artery embolization agent can be used for treating liver cancer.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of sevelamer. Background technique

[0002] Sevelamer generally includes Sevelamer hydrochloride and Sevelamer carbonate, which have the same active ingredient. Taking sevelamer hydrochloride as an example, its chemical name is 2-propenyl-1-amino-2-chloromethyloxirane (1:1), and the molecular formula of the monomer is C 6 h 12 ClNO has a molecular weight of 149.619. Sevelamer Carbonate replaces chlorine ions with bicarbonate ions to reduce the electrolyte disturbance that may be caused after oral administration. There is no difference in the physical and chemical properties and phosphate binding properties of the two, so Sevelamer referred to in the present invention includes both Sevelamer Hydrochloride. Vilamer also includes sevelamer carbonate. The structural formulas of the two are shown below.

[0003] Formula 1: Formula 2:

[0004] F...

Claims

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