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Electrostatic spinning gel fiber membrane as well as preparation method and application thereof

A silk gel fiber, electrospinning technology, applied in textiles and papermaking, fiber chemical characteristics, conjugated rayon, etc., can solve the problems of complex preparation method, complex process, high cost of large-scale production, etc. Effects of adhesion wound healing, promotion of adhesion, good hydrophilicity and mechanical properties

Inactive Publication Date: 2021-06-22
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN111068107A discloses a three-dimensional bionic self-healing hydrogel fiber scaffold composition and its preparation method and application, but this patent uses a three-step method of electrospinning, self-crosslinking and mold forming to prepare a scaffold with biomedical applications. Complex, expensive to produce at scale
But the preparation method of this invention is comparatively complicated

Method used

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  • Electrostatic spinning gel fiber membrane as well as preparation method and application thereof
  • Electrostatic spinning gel fiber membrane as well as preparation method and application thereof
  • Electrostatic spinning gel fiber membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] In this embodiment, an electrospinning gel fiber membrane is provided, and the preparation raw materials of the electrospinning gel fiber membrane include an electrospinning solution A and an electrospinning solution B, and the electrospinning solution A is carboxylated A mixed solution of methyl chitosan, polyvinyl alcohol and deionized water, the electrospinning solution B is a mixed solution of sodium hyaluronate, polyvinyl alcohol and deionized water.

[0072] Wherein, the carboxymethyl substitution degree of carboxymethyl chitosan is 85%, the degree of hydroformylation of sodium hyaluronate is 80%; the mass fraction of carboxymethyl chitosan in electrospinning solution A is 0.05% , the mass fraction of polyvinyl alcohol is 5%, and the rest is deionized water; the mass fraction of sodium hyaluronate hyaluronate in electrospinning solution B is 10%, the mass fraction of polyvinyl alcohol is 5%, and the rest is deionized water Water; the volume ratio of electrospinnin...

Embodiment 2

[0088] In this embodiment, an electrospinning gel fiber membrane is provided, and the preparation raw materials of the electrospinning gel fiber membrane include an electrospinning solution A and an electrospinning solution B, and the electrospinning solution A is carboxylated A mixed solution of methyl chitosan, polyvinyl alcohol and deionized water, the electrospinning solution B is a mixed solution of sodium hyaluronate, polyvinyl alcohol and deionized water.

[0089] Wherein, the carboxymethyl substitution degree of carboxymethyl chitosan is 25%, the degree of hydroformylation of sodium hyaluronate is 60%; the mass fraction of carboxymethyl chitosan in electrospinning solution A is 5%. , the mass fraction of polyvinyl alcohol is 10%, and the rest is deionized water; the mass fraction of sodium hyaluronate hyaluronate in electrospinning solution B is 5%, the mass fraction of polyvinyl alcohol is 8%, and the rest is deionized water Water; the volume ratio of electrospinning ...

Embodiment 3

[0104] In this embodiment, an electrospinning gel fiber membrane is provided, and the preparation raw materials of the electrospinning gel fiber membrane include an electrospinning solution A and an electrospinning solution B, and the electrospinning solution A is carboxylated A mixed solution of methyl chitosan, polyethylene oxide and deionized water, the electrospinning solution B is a mixed solution of sodium carboxymethyl cellulose, polyvinyl alcohol and deionized water.

[0105] Wherein, the degree of substitution of carboxymethyl chitosan of carboxymethyl chitosan is 50%, the degree of hydroformylation of sodium carboxymethyl cellulose is 40%; the mass fraction of carboxymethyl chitosan in electrospinning solution A is 10%, the mass fraction of polyethylene oxide is 15%, and the rest is deionized water; the mass fraction of sodium carboxymethylcellulose in electrospinning solution B is 10%, and the mass fraction of polyvinyl alcohol is 20%, The rest is deionized water; t...

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Abstract

The invention provides an electrostatic spinning gel fiber membrane and a preparation method and application thereof. The electrostatic spinning gel fiber membrane is prepared from an electrostatic spinning solution A and an electrostatic spinning solution B. The electrostatic spinning solution A is a mixed solution of carboxymethyl chitosan, a water-soluble polymer and deionized water; the electrostatic spinning solution B is a mixed solution of hydroformylated polysaccharide, a water-soluble polymer and deionized water. The electrostatic spinning solution A and the electrostatic spinning solution B which have chemical reactivity are used for common electrostatic spinning, and gel is formed in situ through Schiff base reaction between carboxymethyl chitosan and hydroformylated polysaccharide; the prepared electrostatic spinning gel fiber membrane can be used as a wound dressing to directly act on damaged tissues such as skin, abdominal cavity, liver, spleen, pelvic cavity and the like of mammals, and has the effects of stopping bleeding, preventing adhesion and promoting wound healing.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and relates to an electrostatic spinning gel fiber membrane, a preparation method and application thereof. Background technique [0002] Medical dressing is a medical material that can temporarily protect wounds, prevent wound contamination, and promote healing. As an important medical product, medical dressings play a critical role in wound healing. In theory, a wound covering with excellent performance can temporarily play the role of barrier repair and provide a favorable microenvironment for wound repair. [0003] Electrospun fiber membranes have the characteristics of high porosity, high specific surface area, and the fine structure size of biomimetic natural tissues, which has attracted extensive attention in the application of wound dressings. As far as the electrospun fiber membrane is concerned, its physical structure is very similar to the extracellular matrix network, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44D04H1/728D01F8/10D01F8/18D01F8/16
CPCA61L15/28A61L15/42A61L15/44D04H1/728D01F8/10D01F8/18D01F8/16C08L5/08C08L5/04C08L3/04C08L1/286
Inventor 石长灿刘雯季志孝杨啸李徐坚
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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