Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of choline polysaccharide conductive nerve tissue engineering hydrogel material and its preparation method and application

A technology of nerve tissue and hydrogel, applied in tissue regeneration, prosthetics, medical science, etc., can solve problems such as the inability to take into account the excellent electrical conduction and biological signal transmission functions, and the lack of biological signal transmission capabilities, and achieve the effect of high mechanical properties

Active Publication Date: 2022-04-19
HARBIN INST OF TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the existing conductive nerve tissue engineering hydrogel materials cannot take into account the excellent conduction and biological signal conduction functions, resulting in the lack of biological signal conduction ability of the conductive nerve tissue engineering hydrogel materials, and provide a choline Polysaccharide conductive nerve tissue engineering hydrogel material, preparation method and application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of choline polysaccharide conductive nerve tissue engineering hydrogel material and its preparation method and application
  • A kind of choline polysaccharide conductive nerve tissue engineering hydrogel material and its preparation method and application
  • A kind of choline polysaccharide conductive nerve tissue engineering hydrogel material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0066] Specific embodiment one: In this embodiment, a choline polysaccharide conductive nerve tissue engineering hydrogel material uses chitosan as a raw material, and a carboxyl group is introduced into the C6 hydroxyl group of chitosan through an etherification reaction to obtain carboxymethyl chitosan. Then carboxymethyl chitosan and 3,4-dihydroxybenzaldehyde are reacted by Schiff base to obtain catechol carboxymethyl chitosan, and then choline is grafted to catechol carboxymethyl chitosan Sugar C6 carboxyl group, obtain choline-catechol carboxymethyl chitosan, finally add pyrrole, ferric chloride and Calcium chloride, using the coordination between phenolic hydroxyl group and iron ion, the coordination between carboxyl group and calcium ion, and the hydrogen bond between polypyrrole and polysaccharide to obtain the choline polysaccharide conductive nerve tissue engineering hydrogel material.

[0067] The catechol carboxymethyl chitosan described in this embodiment contains...

specific Embodiment approach 2

[0069] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the preparation method of described choline is completed according to the following steps:

[0070] Add 250 μL of 2-aminoethanol to a 50 mL three-necked flask, then add 20 mL of anhydrous methanol and 2 g of anhydrous K 2 CO 3 , then feed nitrogen into the three-necked flask, add 500 μL iodomethane under nitrogen atmosphere and magnetic stirring conditions, and finally stir under nitrogen atmosphere, room temperature and stirring conditions for 10 h to obtain the reaction product; put the reaction product in an oven at 25 ° C Dry for 12 hours to obtain 2-hydroxy-N', N', N'-trimethylethylamine, which is choline. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0071] Specific embodiment three: This embodiment is a preparation method of a choline polysaccharide conductive nerve tissue engineering hydrogel material, which is completed according to the following steps:

[0072] One, prepare carboxymethyl chitosan:

[0073] ①. Chitosan and sodium hydroxide are added to the isopropanol aqueous solution, and then swelled and alkalized to obtain the isopropanol aqueous solution of chitosan;

[0074] ②, chloroacetic acid is dissolved in isopropanol to obtain the isopropanol solution of chloroacetic acid;

[0075] ③. Add the isopropanol solution of chloroacetic acid to the isopropanol aqueous solution of chitosan to obtain the reaction solution I; stir the reaction solution I, and finally add the ethanol solution to terminate the reaction, and then vacuum filter to obtain the solid reaction solution Product I;

[0076] ④, washing the solid reaction product to obtain a dehydration and desalination product; vacuum drying the dehydration and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

A choline polysaccharide conductive nerve tissue engineering hydrogel material and its preparation method and application, which relate to a conductive nerve tissue engineering polysaccharide hydrogel and a preparation method thereof. The purpose of the present invention is to solve the problem that the existing conductive nerve tissue engineering hydrogel materials cannot take into account the excellent conduction and biological signal transmission functions, resulting in the lack of biological signal transmission ability of the conductive nerve tissue engineering hydrogel materials. Method; 1. Preparation of carboxymethyl chitosan; 2. Preparation of catechol carboxymethyl chitosan; 3. Preparation of choline-catechol carboxymethyl chitosan; 4. Preparation of choline polysaccharide conductive Hydrogel materials for neural tissue engineering. A choline polysaccharide conductive nerve tissue engineering hydrogel material is used as a nerve tissue engineering material for promoting defect nerve repair. The invention can obtain a choline polysaccharide conductive nerve tissue engineering hydrogel material.

Description

technical field [0001] The invention relates to a conductive nerve tissue engineering polysaccharide hydrogel and a preparation method thereof. Background technique [0002] Nerve injury repair is a major problem facing regenerative medicine. Autologous nerve transplantation is the gold standard for the treatment of peripheral nerve injuries, but health-sensing nerve resection leads to additional wounds and loss of sensation, and limited donor nerves are difficult to meet the needs of a wide range of nerve injury repair sources . Nerve repair is a dynamic and complex process that relies on the regulation of cell signaling factors to achieve efficient and ideal repair effects. Exploring cell signaling factors that are beneficial to nerve repair is an urgent problem to be solved in the field of neural tissue engineering material development. Choline can be used as a signal molecule to protect nerves and maintain neuroplasticity, transmit information between nerve cells, and r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/52A61L27/54A61L27/50C08L5/04C08L5/08C08L79/04C08J3/075C08J3/24C08K3/24C08B37/08
CPCA61L27/18A61L27/20A61L27/52A61L27/54A61L27/50C08J3/246C08J3/075C08B37/003C08J2305/04C08J2405/08C08J2479/04C08K3/16C08K2003/162A61L2430/32A61L2300/232A61L2300/404C08L5/04C08L5/08C08L79/04
Inventor 王路刘延浩李书彬王振宇
Owner HARBIN INST OF TECH
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com