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Vascular stent with self-driven piezoelectric response to regulate surface hydrophilicity and hydrophobicity and preparation method thereof

A vascular stent, self-driving technology, applied in the direction of blood vessels, stents, electrospinning, etc., can solve the problem of inability to self-regulate in vivo, and achieve the goal of inhibiting the regeneration of normal vascular endothelial cells, inhibiting excessive cell proliferation, and increasing the risk of thrombosis. Effect

Active Publication Date: 2021-11-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It mainly includes a support net, and the surface of the support net is covered with an anti-thrombotic film. The anti-thrombotic film uses an endothelialized film to release endothelialized substances, and also includes a controlled-release film covering the endothelialized film, which reduces the formation of thrombus through endothelialization. However, its effects are time-sensitive and cannot be self-regulated in vivo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for self-driven piezoelectric response regulation of surface hydrophilic and hydrophobic vascular stents, the specific steps are as follows:

[0051] (1) First obtain the vascular structure of the stent to be implanted by CT angiography, then construct a three-dimensional model in the computer according to the vascular structure of the stent to be implanted, and finally complete the processing by a 3D printer to obtain The bracket body is made of stainless steel;

[0052] (2) Polyvinylidene fluoride and AgNO 3 Dissolved in deionized water, then at 23°C, after magnetic stirring for 2h, heated in a water bath at 60°C for 3h to obtain an electrospinning solution;

[0053] The mass fraction of polyvinylidene fluoride in the electrospinning solution was 1 wt%, AgNO 3 The mass fraction of is 0.3wt%;

[0054] (3) To transform the electrospinning device, the transformation method is as follows: the inner layer of all connecting pipes of the electrospinning device is...

Embodiment 2

[0064] A method for self-driven piezoelectric response regulation of surface hydrophilic and hydrophobic vascular stents, the specific steps are as follows:

[0065] (1) First obtain the vascular structure of the stent to be implanted by CT angiography, then construct a three-dimensional model in the computer according to the vascular structure of the stent to be implanted, and finally complete the processing by a 3D printer to obtain The bracket body is made of stainless steel;

[0066] (2) Polyvinylidene fluoride and FeCl 3 ·6H 2 O was dissolved in tetrahydrofuran, then at 24°C, after magnetic stirring for 1h, heated in a water bath at 40°C for 5h to obtain an electrospinning solution;

[0067] The mass fraction of polyvinylidene fluoride in the electrospinning solution is 20wt%, FeCl 3 ·6H 2 The mass fraction of O is 2wt%;

[0068] (3) To transform the electrospinning device, the transformation method is as follows: the inner layer of all connecting pipes of the electr...

Embodiment 3

[0078] A method for self-driven piezoelectric response regulation of surface hydrophilic and hydrophobic vascular stents, the specific steps are as follows:

[0079] (1) First obtain the vascular structure of the stent to be implanted by CT angiography, then construct a three-dimensional model in the computer according to the vascular structure of the stent to be implanted, and finally complete the processing by a 3D printer to obtain The bracket body is made of stainless steel;

[0080] (2) Dissolving polyvinylidene fluoride and nano-graphene in trifluoroacetic acid, then stirring magnetically at 25°C for 12h, then heating for 4h in a water bath at 50°C to obtain an electrospinning solution;

[0081] The mass fraction of polyvinylidene fluoride in the electrospinning solution is 3wt%, and the mass fraction of nanographene is 0.6wt%;

[0082] (3) To transform the electrospinning device, the transformation method is as follows: the inner layer of all connecting pipes of the el...

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Abstract

The invention relates to a vascular stent with a self-driven piezoelectric response to regulate the hydrophilic and hydrophobic surface and a preparation method thereof. The preparation method is as follows: firstly obtain the vascular structure of the stent to be implanted by CT angiography, and then obtain the vascular structure of the stent to be implanted according to the vascular structure of the stent to be implanted. Structure A three-dimensional model that fits the vascular structure is constructed in the computer, and then the stent body is obtained by 3D printing. Finally, the surface of the stent body is covered with a polyvinylidene fluoride fiber membrane sprayed with polythiophene microspheres to obtain a self-driven piezoelectric response regulation A vascular stent with a hydrophilic and hydrophobic surface; the polyvinylidene fluoride fiber membrane sprayed with polythiophene microspheres on the surface of the prepared vascular stent includes a basement membrane and a polythiophene microsphere coating containing an anion dopant; the peak value of the piezoelectric signal of the basement membrane The voltage is 0.5-3V, and the threshold value of wettability transition on the surface of the vascular stent is 0.05-0.5V. The covering film on the surface of the vascular stent of the present invention has the characteristics of self-driven piezoelectric response to regulate the hydrophilicity and hydrophobicity of the surface, and can realize the effect of preventing thrombus.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and relates to a self-driven piezoelectric response regulating surface hydrophilic and hydrophobic blood vessel stent and a preparation method thereof. Background technique [0002] The morbidity and mortality of cardiovascular diseases in the world are showing an increasing trend year by year. Due to the occurrence of thrombus in blood vessels, the commonly used clinical treatment methods are the implantation of autologous blood vessels and artificial blood vessels. Due to the limited source of autologous blood vessels, artificial blood vessels are generally used. However, due to biocompatibility and other reasons, implanted artificial blood vessels are prone to platelet adhesion and smooth muscle cell proliferation after contact with blood, which in turn leads to vascular restenosis and thrombus. [0003] The principle of thrombus is: the abnormal coagulation of organic components in the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61F2/06A61F2/07D01D5/00B33Y50/00B33Y80/00
CPCA61F2/06A61F2/07A61F2240/001A61L31/10A61L31/14A61L31/16A61L2300/216A61L2300/424A61L2300/606A61L2300/622A61L2400/12B33Y50/00B33Y80/00D01D5/003D01D5/0069D10B2509/06C08L27/16
Inventor 王富军卞旻玥刘力梦曾心怡陈旻李超婧王璐
Owner DONGHUA UNIV
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