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Dual-drug controlled release system with pH and glutathione dual response and preparation method of dual-drug controlled release system

A double-response, glutathione technology, applied in the field of material synthesis and biomedicine, can solve the problems of single drug delivery system, which cannot meet clinical treatment, and achieve the effects of avoiding burst release, good biodegradability, and avoiding leakage

Active Publication Date: 2021-06-25
CHANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, previous studies focused on a single drug delivery system, which often cannot meet the needs of clinical treatment

Method used

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  • Dual-drug controlled release system with pH and glutathione dual response and preparation method of dual-drug controlled release system
  • Dual-drug controlled release system with pH and glutathione dual response and preparation method of dual-drug controlled release system
  • Dual-drug controlled release system with pH and glutathione dual response and preparation method of dual-drug controlled release system

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Embodiment 1

[0049] A method for preparing a dual-drug controlled-release system with dual responses to pH and glutathione, comprising the following steps:

[0050] (1) Weigh 0.9g of cetyltrimethylammonium bromide, add it to the mixed solution of 1.4mL ammonia water, 90mL deionized water and 70mL ethanol, stir the mixed solution mechanically for 30 minutes, then add 0.8mL normal Ethyl silicate and 0.4 mL of 3-aminopropyltriethoxysilane were successively added dropwise to the continuously stirred solution, reacted for 6 hours, and the precipitate was centrifuged and washed repeatedly with deionized water and absolute ethanol After drying, put the dried product into a mixed solution of 90 mL of anhydrous methanol and 5 mL of hydrochloric acid and reflux at 75 °C for 24 h to remove the template agent hexadecyltrimethylammonium bromide. After repeating 3 times, the product was used without Repeated washing with water, ethanol and deionized water, drying at 50°C and grinding to obtain aminated ...

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Abstract

The invention belongs to the field of material synthesis and biological medicine, and relates to a dual-drug controlled release system with pH and glutathione dual response and a preparation method thereof.The dual-drug controlled release system is constructed by adopting mesoporous silica, and sodium hyaluronate serves as a gating material to block pore channels of the mesoporous silica; Mesoporous channels of the mesoporous silica are loaded with cytarabine. The mesoporous silica, the chitosan and the sodium carboxymethyl cellulose form a gel system, and methotrexate is loaded in the gel system. The preparation method has the beneficial effects that the prepared pH and glutathione dual-response dual-drug controlled release system can load two anti-cancer drugs at the same time, and realizes the successive release of the two drugs in a subacid tumor environment and a high-concentration glutathione environment. The double-drug controlled release system is simple to prepare and high in biocompatibility, and can be widely applied to the field of biological medicines.

Description

technical field [0001] The invention relates to a dual-drug controlled-release system with dual responses to pH and glutathione and a preparation method thereof, belonging to the fields of material synthesis and biomedicine. Background technique [0002] Single-drug controlled-release system is a kind of drug controlled-release system that has been widely studied at present. However, long-term use of a single anticancer drug will eventually enhance the drug resistance of cancer cells, thereby reducing the therapeutic effect. Therefore, the research and development of dual-drug controlled release system has aroused widespread concern of scientists. Over the past decades, researchers have developed a variety of controlled drug release systems to deliver different drugs or bioactive substances. However, previous studies focused on a single drug delivery system, which often cannot meet the needs of clinical treatment. Furthermore, the fields of medicine and biomedicine often ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/519A61K31/7068A61K47/36A61K47/38A61K47/69A61P35/00C01B33/18
CPCA61K31/7068A61K31/519A61K9/06A61K47/36A61K47/38A61K47/6949A61P35/00C01B33/18C01P2004/03C01P2002/82A61K2300/00
Inventor 孔泳李尚基康静
Owner CHANGZHOU UNIV
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