Synthesis method of degradable block copolymer hydrogel

Abstract

The invention belongs to the field of biological medicine and chemical industry, and particularly relates to a synthesis method of degradable block copolymer hydrogel. The degradable block copolymer hydrogel is obtained by copolymerization of epsilon-caprolactone and polyethylene glycol as raw materials, and the synthesis method comprises the specific steps: weighing epsilon-caprolactone and polyethylene glycol, respectively carrying out water removal pretreatment on the epsilon-caprolactone and the polyethylene glycol by using a molecular sieve, adding the epsilon-caprolactone and the polyethylene glycol into a reactor, adding a catalyst, and reacting for 2-6 hours at the temperature of 100-150 DEG C under the protection of nitrogen to obtain a PCL-PEG-PCL block copolymer crude product; and dissolving, precipitating and drying the crude product to obtain the PCL-PEG-PCL degradable block copolymer hydrogel. The hydrogel has biocompatibility and degradability, the gel phase transition temperature (LCST) is within the human body temperature range, the used raw materials are easy to obtain and low in price, and the synthesis method is simple and easy to implement.

Description

technical field [0001] The invention belongs to the field of biomedicine and chemical industry, and in particular relates to a synthesis method of a degradable block copolymer hydrogel. Background technique [0002] Hydrogel is a cross-linked network formed by hydrophilic polymers under the action of chemical bonds, hydrogen bonds or van der Waals forces. maintain the original structure". Compared with other synthetic materials, hydrogel is closer to living tissue, its surface has weaker adhesion to proteins and cells, and has good biocompatibility when in contact with human tissue, blood and body fluids. In addition, because the hydrogel has a three-dimensional network structure, metabolites can be excreted through it without affecting the metabolic process of living organisms. Due to the above-mentioned characteristics of hydrogel, it has a bright application prospect in the fields of tissue engineering and biomedicine (such as drug sustained release carrier, tissue engi...

AI Technical Summary

Problems solved by technology

Chitosan, polyvinyl alcohol, acrylamide, sodium alginate and other hydrogels have problems such as insufficient mechanical strength, unstable grid structure, short maintenance time in vivo, and sudden release of drugs. The phase transition of most hydrogels The temperature can never be controlled within the range of human body temperature

Patent CN105131264A discloses a copolymer hydrogel of PEG and polyethylene lactide, which has advantages in biocompatibility and degradation control, and the phase transition temperature can also be controlled within the body temperature range of the human body. However, lactide, glycolide Ester monomers are not easy to obtain, and the preparation cost is high, resulting in high cost of hydrogel