Preparation method of high-aperture controllable magnetic silica gel microspheres

Abstract

The invention discloses a preparation method of high-aperture controllable magnetic silica gel microspheres, which comprises the following steps: preparing small-particle-size silica gel microsphere seeds from acidic SiO2 sol, a urea solution and distilled water, conducting filtering and washing to obtain magnetic microsphere silica gel, controlling growth through urea and formaldehyde, and adding acetone or a mixed solution to control the aperture of the high-aperture magnetic silica gel microsphere. According to the preparation method, the high-aperture controllable magnetic silica gel microspheres with uniform particle size can be prepared by selecting the magnetic silica gel microspheres with better particle size uniformity as the seeds and adding the acetone for 40-55 minutes for secondary diameter expansion, and the particle size of the high-aperture magnetic silica gel microspheres can be controlled by changing the input amount and the reaction time of the soluble ferric ion salt and the polyglutamic acid. A large number of cheap high-aperture magnetic silica gel microspheres are prepared by adopting a solvothermal method, the method has the advantages that the raw materials are cheap and easy to obtain, the process is quite simple, the production is easy to amplify, and the obtained product has a relatively large performance regulation space, stable quality and good controllability.

Description

technical field [0001] The invention relates to the technical field of silica gel preparation, in particular to a preparation method of magnetic silica gel microspheres with high pore size and controllable size. Background technique [0002] Silica gel is a highly active adsorption material, which is an amorphous substance; it does not react with any substance except strong alkali and hydrofluoric acid, insoluble in water and any solvent, non-toxic, tasteless, and stable in chemical properties. Various types of silica gel form different microporous structures due to their different manufacturing methods. The chemical composition and physical structure of silica gel determine that it has many characteristics that other similar materials cannot replace: high adsorption performance, good thermal stability, stable chemical properties, and high mechanical strength. Silica gel can be divided into macroporous silica gel, coarse-porous silica gel, B-type silica gel, and fine-pore s...

AI Technical Summary

Problems solved by technology

[0003] Magnetic microspheres are a new type of functional microspheres composed of magnetic materials and non-magnetic materials. They have been widely used in bioseparation, drug controlled release, disease diagnosis and other fields. It can quickly extract and separate solutions under the action of an external magnetic field. The target analyte in it has the advantages of simple operation, high efficiency, low cost, and good safety, but the synthesis process is complicated, and the specific surface area of ​​the obtained magnetic microspheres is small