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External delivery analgesic composition and application thereof

A technology of composition and mixture, which is applied in the field of labor analgesia, can solve problems such as inconvenient administration, motion blockage, and technical risks, and achieve the effects of enhancing analgesic effect, promoting extraction, and reducing degradation speed

Pending Publication Date: 2021-07-16
泰州市第二人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has high technical content and needs to be operated by anesthesiologists who have professional skills in anesthesia, and the administration is not easy; there are technical risks, accompanied by a 3% analgesic failure rate; and when the drug dose and concentration are selected improperly, Adverse effects on movement block, labor process and mother and baby
Intraspinal injection of labor analgesia has certain operational and technical risks

Method used

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  • External delivery analgesic composition and application thereof
  • External delivery analgesic composition and application thereof
  • External delivery analgesic composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Polyethylene Glycol Long Chain Alkylamine (Polyethylene Glycol 1000 Octadecylamine):

[0024]

[0025] Alkyl chain contains 18 carbon atoms, polyethylene glycol fragment molecular weight is the polyethylene glycol long-chain alkylamine preparation method of 1000: in the autoclave of 500ml, add the polyethylene glycol monomethyl ether of molecular weight 1000 ( mPEG1000) 100 grams (0.1mol), silicon dioxide 3 grams (0.05mol), aluminum oxide 10 grams (0.1mol), octadecylamine 27 grams (0.1mol), after reacting for 36 hours at 180 degrees centigrade, water and Extracted three times with ethyl acetate. The aqueous layer was removed, and the organic layer was dried over anhydrous sodium sulfate. Remove the solvent with a rotary evaporator, then extract the product with dichloromethane and evaporate the solvent to obtain 111 grams of polyethylene glycol octadecylamine (1), with a yield of 89%

Embodiment 2

[0027] Preparation of Polyethylene Glycol Long Chain Alkylamine (Polyethylene Glycol 500 Cetylamine):

[0028]

[0029] Alkyl chain contains 16 carbon atoms, polyethylene glycol segment molecular weight is the polyethylene glycol long-chain alkylamine preparation method of 500: in the autoclave of 500ml, add the polyethylene glycol monomethyl ether ( mPEG500) 50 grams (0.1mol), silicon dioxide 3 grams (0.05mol), aluminum oxide 10 grams (0.1mol), hexadecylamine 26 grams (0.1mol), after reacting for 36 hours at 180 degrees Celsius, water and Extracted three times with ethyl acetate. The aqueous layer was removed, and the organic layer was dried over anhydrous sodium sulfate. Remove the solvent with a rotary evaporator, then extract the product with dichloromethane and evaporate the solvent to obtain 65 grams of polyethylene glycol cetylamine (2), with a yield of 88%

Embodiment 3

[0030] Example 3 (composition 1)

[0031] Weigh 20 grams of polyethylene glycol 1000 octadecylamine, 15 grams of raw pinellia, 15 grams of raw southern star, 15 grams of raw Aconitum aconiti, 15 grams of raw grass aconitum, 20 grams of glycerin and 300 grams of pure water; Xia, Shengnanxing, Shengchuanwu and Shengcaowu are ground together into powder; the obtained powder is boiled with polyethylene glycol 1000 octadecylamine, glycerin, and pure water for 1 hour, and the solid medicinal residue is filtered out while heating. Collect the filtrate; heat and concentrate the obtained filtrate in a water bath at 50-60°C to 1 / 4 of the total volume of the solution before the water bath, and cool to obtain a paste, which is the external labor analgesic composition.

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PUM

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Abstract

The invention provides an external delivery analgesic composition which has a synergistic effect with a polymer. Wherein the synergist is polyethylene glycol long-chain alkylamine, on one hand, polyethylene glycol fragments can effectively wrap traditional Chinese medicine active ingredients (raw pinellia ternate, raw arisaema consanguineum schott, raw radix aconiti and raw radix aconiti kusnezoffii) through the coordination effect of many oxygen atoms, and long-chain alkyl fragments generate an isolation effect, so that the degradation speed of the active ingredients is reduced, and long-acting analgesia is realized. On the other hand, as an effective surfactant, the polyethylene glycol long-chain alkylamine can more effectively promote extraction of the active ingredients and dispersion and permeation on the skin surface, and the analgesic effect is enhanced.

Description

technical field [0001] The invention relates to the field of labor analgesia, in particular to a highly dispersed labor analgesic composition. Background technique [0002] At present, the most reliable and widely used method for labor analgesia recognized at home and abroad is intraspinal injection of drugs for analgesia, and the effective rate of analgesia reaches more than 95%. However, this method has high technical content and needs to be operated by anesthesiologists with professional anesthesia skills, and the administration is not easy; there are technical risks, accompanied by a 3% analgesic failure rate; and when the drug dose and concentration are selected improperly, It has adverse effects on movement block, labor process and mother and baby. Neuraxial injection of labor analgesia has certain operational and technical risks. [0003] Therefore, it is an urgent need for obstetrics and gynecology medical staff and parturients to seek a drug that is easy to admini...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/70A61K9/00A61K36/8888A61K47/18A61P29/00A61P15/00
CPCA61K9/06A61K9/7023A61K9/0014A61K36/8888A61K36/8884A61K36/714A61K47/18A61P29/00A61P15/00A61K2236/331A61K2236/51A61K2300/00
Inventor 周爱华
Owner 泰州市第二人民医院
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