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Guided tissue regeneration membrane and preparation method and application thereof

A technology for guiding tissue regeneration and biology, applied in the field of medical materials, can solve the problems of non-degradable regenerative membrane, poor plasticity of degradable membrane, easy collapse of tissue, etc., and is suitable for mass production, assisting bone growth and healing, preparation Simple and easy method

Active Publication Date: 2022-07-19
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In view of the technical problems existing in the prior art, for example: degradable membranes commonly used in clinical practice have poor shapeability, and the tissue is prone to collapse; existing clinical guiding tissue regeneration membranes with space support or shapeability cannot degradation issues, etc.

Method used

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  • Guided tissue regeneration membrane and preparation method and application thereof
  • Guided tissue regeneration membrane and preparation method and application thereof
  • Guided tissue regeneration membrane and preparation method and application thereof

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preparation example Construction

[0111] A second aspect of the present invention provides a method for preparing a guided tissue regeneration membrane according to the first aspect, comprising the step of compounding the fiber aggregate and the shaped body.

[0112] Typically, the preparation method comprises the following steps:

[0113] 3D printing process: prepare polymer material slurry, and use 3D printing technology to prepare the shaped body; in other specific embodiments, after mixing polymer material and osteogenic induction powder to form a printing slurry, use 3D printing technology The shaped body is prepared.

[0114] Electrospinning process: between the second fibers and / or on the surface of the second fibers, the fiber aggregate is prepared by electrospinning technology.

[0115] It is worth noting that the 3D printing process is carried out simultaneously with the electrospinning process.

[0116] In the present invention, the guided tissue regeneration membrane of the present invention is p...

Embodiment 1

[0146] The degradable polymer material poly(lactic-co-glycolic acid) (PLGA; LA / GA=50:50) particles were placed in the barrel of the printer.

[0147] The degradable polymer material polylactic acid was dissolved in the organic solvent chloroform to prepare a solution with a concentration (mass volume ratio) of 6%. In the bioglass solution, the content of calcium is 36 mole fractions, the content of silicon (ethyl orthosilicate) is 60 mole fractions, and the content of phosphorus (triethyl phosphate) is 8 mole fractions. The ester was hydrolyzed in hydrochloric acid with a pH value of 1.5. During hydrolysis, the molar ratio of silicon to deionized water was 1:8; after the hydrolysis was completed, triethyl phosphate was added to continue the hydrolysis, and after the hydrolysis was completed, calcium acetate was dissolved and allowed to stand for 6 hours. , to obtain the bioglass solution, ready for electrospinning.

[0148] The printing model is set as a square grid, the temp...

Embodiment 2

[0154] The degradable polymer material polycaprolactone (PCL) is prepared into powder by the method of freeze grinding, and the tricalcium phosphate powder with a particle size of 500nm-10μm is evenly mixed with the polycaprolactone powder, and placed in the printer. In the barrel, the mass ratio of polycaprolactone to tricalcium phosphate powder is 1:5.

[0155] The degradable polymer material polyglycolic acid (PGA) and hydrophilic factor gelatin are dissolved in the organic solvent trifluoroethanol according to the mass ratio of 3:1 to prepare a solution with a concentration (mass volume ratio) of 20% . In the bioactive glass solution, the content of calcium is 50 mole fractions, the content of silicon is 50 mole fractions, and the phosphorus content is 12 mole fractions. During hydrolysis, ethyl orthosilicate is hydrolyzed in hydrochloric acid with a pH value of 1.5. During hydrolysis, the molar ratio of silicon to deionized water is 1:10; after the hydrolysis is complete...

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Abstract

The invention provides a guiding tissue regeneration membrane and a preparation method and application thereof. The guiding tissue regeneration membrane includes a fiber aggregate and a shaping body; the fiber aggregate is interwoven by first fibers, the shaping body comprises at least one second fiber, and the first fiber and the second fiber are interspersed with each other, and / or, a part of the first fiber is adhered to the surface of the second fiber; wherein, the diameter of the second fiber is larger than the diameter of the first fiber, and the diameter of the first fiber is 10 nm-50 μm; the second fiber The diameter of the fibers is 50 μm-500 μm. The guiding tissue regeneration membrane of the present invention can be shaped according to the bone defect of the patient, and can play the role of barrier and guiding tissue regeneration in the process of bone tissue healing; further, the guiding tissue regeneration membrane of the present invention can be completely absorbed by the human body, No second surgery is required.

Description

technical field [0001] The invention relates to a guiding tissue regeneration membrane, a preparation method and application thereof, and belongs to the field of medical materials. Background technique [0002] Guided Tissue Regeneration (GTR) is a new technology developed in the late 1980s and early 1990s. The principle is to use the physical barrier function of the membrane to isolate the damaged area from the surrounding tissue, creating a relatively closed tissue environment, so that the regeneration function of a specific tissue can be maximized. This technology was initially used in animal experiments and clinical studies of periodontal disease treatment, and was subsequently used to promote the repair and regeneration of bone tissue, that is, Guided Bone Regeneration (GBR). Therefore, the application of guided tissue regeneration technology provides a new and effective way for the treatment of periodontal disease, the repair of insufficient bone mass in dental implan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/60A61L27/10A61L27/12A61L27/18B33Y10/00B33Y70/10B33Y80/00D01D5/00
CPCA61L27/50A61L27/60A61L27/10A61L27/12A61L27/18B33Y10/00B33Y70/00B33Y80/00D01D5/0007D01D5/003D01D5/0015A61L2430/12A61L2400/12C08L67/04C08L75/04
Inventor 张婧莫梅玲邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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