Strontium-containing mesoporous bioglass-magnesium composite and preparation method therefor and application of composite

A technology of biological glass and composite materials, applied in tissue regeneration, medical science, prosthesis, etc., to achieve the effect of uniform calcium and phosphorus layer, high strontium loading and regular shape

Inactive Publication Date: 2020-11-06
JIANGXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, strontium has extremely high chemical activity, and it is difficult to introduce strontium directly into the magnesium matrix by means of alloying.

Method used

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  • Strontium-containing mesoporous bioglass-magnesium composite and preparation method therefor and application of composite
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  • Strontium-containing mesoporous bioglass-magnesium composite and preparation method therefor and application of composite

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Step 1: the preparation method of mesoporous bioglass microspheres containing strontium,

[0060] (1) Dissolve 4 g of dodecylamine (DDA) in 125 mL of ethanol aqueous solution, wherein, alcohol: water = 4: 1, stir magnetically for 30 minutes, and the temperature is 40° C.

[0061] (2) Add 16 mL of tetraethyl orthosilicate (TEOS), 1.22 mL of triethyl phosphate (TEP), and 3.99 g of calcium nitrate (CN) to the system of step (1) in an orderly manner, each One-step magnetic stirring for 30min.

[0062] (3) 0.84 g of strontium nitrate (Sr) was added to the system of step (2), and magnetically stirred for 3 h until a white precipitate was formed.

[0063] (4) The solution obtained in step (3) was centrifuged, and washed 3 times with deionized water to obtain a white precipitate.

[0064] (5) Place the white precipitate obtained in step (4) in a vacuum drying oven, set the temperature at 60° C., and dry for 24 hours to obtain a white powder.

[0065] (6) Place the white powd...

Embodiment 2

[0072] Other conditions are all identical with embodiment 1, just distribute according to design group, design biological glass / magnesium powder mass ratio is 8%, weigh the mesoporous biological glass powder 0.8g that contains strontium, 9.2g magnesium-zinc alloy powder (average particle diameter 50μm). Ball milling was performed in an argon protective gas atmosphere to obtain a mixed powder, the rotational speed of the ball mill was 300 rad / min, and the ball milling time was 2 h. Using the above mixed powder as raw material, the magnesium metal of mesoporous bioglass containing strontium was prepared by laser selective melting process. During the preparation process, the laser power was 90W, the scanning speed was 120mm / s, and the laser spot was 100μm

[0073] The test found that compared with magnesium metal with a mass ratio of bioglass / magnesium powder of 5%, the density of magnesium metal showed a downward trend, which accelerated corrosion. The degradation rate of the al...

Embodiment 3

[0075] Other conditions are all identical with embodiment 1, just distribute according to design group, design biological glass / magnesium powder mass ratio is 4%, weigh the mesoporous biological glass powder 0.4g containing strontium, 9.6g magnesium-zinc alloy powder (average particle diameter 50μm). Ball milling was performed in an argon protective gas atmosphere to obtain a mixed powder, the rotational speed of the ball mill was 300 rad / min, and the ball milling time was 2 h. Using the above mixed powder as raw material, magnesium metal of mesoporous bioglass containing strontium was prepared by selective laser melting process. During the preparation process, the laser power was 90W, the scanning speed was 120mm / s, and the laser spot was 100μm. According to measurements, in Example 2, the degradation rate of the obtained strontium-containing mesoporous bioglass-magnesium composite material was 0.38 mm / year, and the compressive strength was 150 MPa.

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Abstract

The invention discloses a strontium-containing mesoporous bioglass-magnesium composite and a preparation method therefor and application of the composite. The composite consists of a magnesium matrixand strontium-containing mesoporous bioglass evenly distributed in the magnesium matrix. The preparation method for the strontium-containing mesoporous bioglass-magnesium composite comprises the stepsof firstly mixing an organic template with a raw material to obtain mixed gel, and then performing high-temperature calcination to obtain strontium-containing mesoporous bioglass microspheres; and after the mesoporous bioglass microspheres are mixed with magnesium powder, preparing the strontium-containing mesoporous bioglass-magnesium metal composite material by utilizing a selective laser melting technology. The composite obtained by the invention has excellent biological activity, can promote formation of a calcium-phosphorus protective layer on the surface to delay degradation of the magnesium matrix, and meanwhile, strontium ions are released in a sustained-and-controlled manner by utilizing highly ordered mesoporous structures of the mesoporous bioglass to achieve long-term bone-promoting effects to accelerate the bone healing process. The composite prepared by the invention is a very great potential bone tissue repair material.

Description

technical field [0001] The invention belongs to the field of multifunctional biomedical materials, and specifically relates to a strontium-containing mesoporous bioglass-magnesium composite material, a preparation method and an application. Background technique [0002] Magnesium metal has natural degradability and good biocompatibility, so it has received extensive attention from the medical community. Magnesium bone implants not only provide good structural support at the initial stage of implantation, but also gradually degrade during bone healing, which can meet the clinical requirements of temporary substitutes. At the same time, magnesium, as an essential element of human metabolism, participates in the metabolism of various bone cells. Furthermore, magnesium metal has a density of ~1.79 g / cm 3 , Young's modulus is ~ 45GPa, which is close to that of human bone. However, magnesium metal degrades too quickly after being implanted into the human body, which will premat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/10A61L27/50A61L27/56
CPCA61L27/047A61L27/10A61L27/50A61L27/56A61L2430/02
Inventor 杨友文帅词俊
Owner JIANGXI UNIV OF SCI & TECH
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