Application of 3-methyladenine in preparation of medicine for preventing acute pneumonia induced by pseudomonas aeruginosa

A technology of Pseudomonas aeruginosa and methyladenine, which is applied in the field of biomedicine to achieve the effect of reducing inflammatory cytokines and bacterial load and avoiding the increasing drug resistance
CN113134004AInactive Publication Date: 2021-07-20INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
Publication Date
2021-07-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to application of 3-methyladenine in preparation of a medicine for preventing acute pneumonia induced by pseudomonas aeruginosa, and belongs to the technical field of biomedicine. Experimental research shows that before pseudomonas aeruginosa infection, the survival rate of experimental animals can be increased by using 3-methyladenine, and meanwhile, host tissue damage caused by excessive inflammatory immune response is avoided along with pathology reduction and reduction of inflammatory cytokines and in-lung bacteria load; and the increasing drug resistance of bacteria to existing antibiotics due to improper use of the antibiotics can be avoided, and the application prospect is wide.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of 3-methyladenine in the preparation of drugs for preventing acute pneumonia induced by Pseudomonas aeruginosa. Background technique

[0002] Pseudomonas aeruginosa is one of the leading causes of nosocomial infections worldwide. Intensive care unit infections, especially ventilator-associated pneumonia, are associated with high mortality. In addition to high virulence, the tendency to develop resistance to multiple antimicrobial agents makes Pseudomonas aeruginosa difficult to control. The fact that clinical isolates of P. aeruginosa resistant to colistin and tigecycline have emerged has prompted us to look for solutions beyond traditional antibiotic therapy. In addition to immunization strategies that include vaccines (active immunization) and antibody administration (passive immunization), other host-targeted interventions have shown potentia...

Claims

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