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A kind of wound disinfectant and preparation method thereof

A disinfectant and wound technology, applied in the field of disinfectant, can solve the problems of poor antibacterial effect

Active Publication Date: 2022-04-12
维尼健康(深圳)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the invention provides a wound disinfectant and its preparation method, which solves the problem of poor antibacterial effect of traditional wound disinfectants

Method used

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  • A kind of wound disinfectant and preparation method thereof

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preparation example Construction

[0026] In order to achieve the above object, the present invention provides the following specific embodiments and examples: a wound disinfectant, the preparation method comprising the following steps:

[0027] (1) Using cellulose and citric acid as raw materials, amidation is carried out in the catalytic system of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide reaction, wherein the mass ratio between cellulose, citric acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide was 100:280- 400:20-40:24-48, the reaction temperature is 50-80°C, and the reaction time is 3-8h. After the reaction is completed, filter, wash with deionized water, and dry to obtain citrated cellulose;

[0028] (2) Using N-dimethyl n-octylamine and epichlorohydrin as raw materials, react in ether solvent to obtain 2-epoxy dimethyl n-octyl quaternary ammonium salt;

[0029] (3) Ultrasonic disperse citrated cellulose in a mixed solven...

Embodiment 1

[0033] (1) Using cellulose and citric acid as raw materials, amidation is carried out in the catalytic system of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide Reaction wherein the mass ratio between cellulose, citric acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide is 100:280: 20:24, the reaction temperature is 50° C., and the reaction time is 3 hours. After the reaction is completed, filter, wash with deionized water, and dry to obtain citrated cellulose;

[0034] (2) Using N-dimethyl n-octylamine and epichlorohydrin as raw materials, react in ether solvent to obtain 2-epoxy dimethyl n-octyl quaternary ammonium salt;

[0035] (3) Ultrasonic disperse citrated cellulose in a mixed solvent of isopropanol and acetone, and then add sodium bicarbonate and 2-epoxy dimethyl n-octyl quaternary ammonium salt for addition esterification, in which lemon The mass ratio between acidified cellulose, sodium bic...

Embodiment 2

[0039] (1) Using cellulose and citric acid as raw materials, amidation is carried out in the catalytic system of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide Reaction wherein the mass ratio between cellulose, citric acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide is 100:300: 25:30, the reaction temperature is 60° C., and the reaction time is 4 hours. After the reaction is completed, filter, wash with deionized water, and dry to obtain citrated cellulose;

[0040] (2) Using N-dimethyl n-octylamine and epichlorohydrin as raw materials, react in ether solvent to obtain 2-epoxy dimethyl n-octyl quaternary ammonium salt;

[0041] (3) Ultrasonic disperse citrated cellulose in a mixed solvent of isopropanol and acetone, and then add sodium bicarbonate and 2-epoxy dimethyl n-octyl quaternary ammonium salt for addition esterification, in which lemon The mass ratio between acidified cellulose, sodium bic...

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Abstract

The invention relates to the field of disinfectant technology, and discloses a wound disinfectant. Compared with the traditional wound disinfectant, the newly prepared wound disinfectant has a better disinfection and antibacterial effect. Cellulose increases water solubility and enhances the antibacterial effect of cellulose quaternary ammonium salt. Cellulose quaternary ammonium salt is a positively charged macromolecular polymer that destroys bacterial activity through adsorption, thereby achieving the purpose of antibacterial. Lizhicao is a mild and non-toxic Chinese herbal medicine. Its main active ingredients include thymol and carvacrol, which can destroy the integrity of the cell membrane structure and achieve the purpose of inactivating bacteria. It is also extracted by supercritical extraction. The large amount of effective substances in Lizhicao avoids the disadvantage that solid matter cannot fully play a role in the disinfectant, and further increases the antibacterial and hemostatic effect of the wound disinfectant.

Description

technical field [0001] The invention relates to the technical field of disinfectant, in particular to a wound disinfectant and a preparation method thereof. Background technique [0002] As the most visible and largest organ of the human body, the skin is an important protective barrier against external stress and also plays an important role in providing sensation, regulating heat and immune response, due to its constant exposure to the external environment, the skin is vulnerable to various external These external factors lead to various skin injuries and damages. Wounds, especially extensive full-thickness wounds, will seriously affect people's daily life and health once they occur. However, full-thickness wound repair usually takes a long time, even It cannot be completely cured, especially in the case of wound infection. For this reason, a simple treatment of the wound with a disinfectant can be used to avoid infection with bacteria. [0003] Wound healing is a multi-s...

Claims

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Application Information

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IPC IPC(8): A61K31/717A61P17/02A61P31/02A61P7/04C08B15/06A61K36/53A61K31/79
CPCA61K36/53A61K31/717A61K31/79A61K9/0014A61P17/02A61P31/02A61P7/04C08B15/06A61K2236/37A61K2300/00Y02P20/54Y02A50/30
Inventor 刘忠杰熊训强石万明
Owner 维尼健康(深圳)股份有限公司
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