Recombinant saccharomyces cerevisiaes for producing 7-dehydrocholesterol and construction method thereof

A technology of dehydrocholesterol and recombinant strains, applied in the field of microbial metabolism, to achieve the effect of increasing production
CN113151027AActive Publication Date: 2021-07-23TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2021-07-23

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Abstract

The invention relates to the field of microbial metabolism, and particularly relates to saccharomyces cerevisiaes for producing 7-dehydrocholesterol and a construction method thereof. The invention discloses two recombinant saccharomyces cerevisiaes for producing 7-dehydrocholesterol, named as saccharomyces cerevisiae SyBE_Sc01250043 and saccharomyces cerevisiae SyBE_Sc01250045, or SyBE_Sc01250043 and SyBE_Sc01250045 for short, as well as a construction method thereof. Compared with the existing reported strains, the recombinant saccharomyces cerevisiaes of the present invention has the advantage of significantly improving yield of 7-dehydrocholesterol.
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Description

technical field

[0001] The invention relates to the field of microbial metabolism, in particular to a saccharomyces cerevisiae strain producing 7-dehydrocholesterol and a construction method thereof. Background technique

[0002] 7-Dehydrocholesterol is a steroid with high added value and is widely used in industry and medicine. It can be used in liquid crystal manufacturing, electromagnetic detection, biomedicine and other fields. 7-dehydrocholesterol can be converted into vitamin D3 by ultraviolet radiation, and 7-dehydrocholesterol in human skin can be converted into vitamin D by sunlight ultraviolet radiation. Vitamin D can be used to treat vitamin D3 deficiency, rickets, etc., familial hypophosphatemia, hypoparathyroidism, etc., and vitamin D deficiency may lead to cardiovascular diseases, metabolic syndrome, cancer, autoimmune diseases, etc. At present, vitamin D3 is mainly obtained from tuna liver oil, or synthesized by photochemical reaction of 7-dehydrocholesterol....

Claims

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