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Titanium material, preparation method and application of nano-hydroxyapatite grown in situ on the surface

A nano-hydroxyapatite, in-situ growth technology, applied in chemical instruments and methods, metal material coating technology, tissue regeneration, etc., can solve problems such as thermal expansion coefficient and elastic modulus mismatch, poor bonding strength, etc. Achieve the effect of controllable uniformity, controllable thickness and low preparation cost

Active Publication Date: 2022-02-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Chinese patent CN106435544A discloses a method for preparing a nano-hydroxyapatite coating on a titanium alloy. Although this method adopts a gradient coating method and uses an inert ceramic as an intermediate layer, the gap between the titanium alloy and the hydroxyapatite is solved. The mismatch of thermal expansion coefficient and elastic modulus caused the problem of poor bonding strength, but the intermediate layer still completely covered the base material, and the thickness reached nearly ten microns

Method used

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  • Titanium material, preparation method and application of nano-hydroxyapatite grown in situ on the surface
  • Titanium material, preparation method and application of nano-hydroxyapatite grown in situ on the surface
  • Titanium material, preparation method and application of nano-hydroxyapatite grown in situ on the surface

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Embodiment 1

[0059] This embodiment discloses the preparation method of the titanium material with in-situ growth of nano-hydroxyapatite on the surface of the present invention, specifically:

[0060] (1) Cleaning and pretreatment of materials: Cut TA2 pure titanium with filiform crystal topological structure on the surface after rolling and heat treatment into the required structure and size, and use acetone, alcohol, and deionized water for ultrasonication successively Cleaning, each solvent cleaning 30min. Then use 280-1500 mesh sandpaper for grinding, after grinding, clean it again with the above cleaning steps, and then dry it. After the sample is dried, place it in an acid mixture consisting of 5% nitric acid, 3% hydrofluoric acid and 92% deionized water by volume and mass, and ultrasonically clean it for 30 seconds, then wash it with deionized water for 5 minutes, and repeatedly wash it with mixed acid and deionized water. Wash with water 3 times and finally dry.

[0061] (2) Asse...

Embodiment 2

[0071] This embodiment discloses the preparation method of the titanium material with in-situ growth of nano-hydroxyapatite on the surface of the present invention, specifically:

[0072] (1) Cleaning and pretreatment of materials: The surface of TA2 pure titanium will be etched with a femtosecond laser to form a material with a groove depth of 1 micron, a width of 1 micron at the top of the groove, and a 90° angle between the ridge and the bottom of the groove. Then cut into the required structure and size, and use acetone, alcohol, and deionized water to clean ultrasonically, each solvent is cleaned for 30 minutes. Then use 280-1500 mesh sandpaper for grinding, and then clean it according to the above cleaning steps after grinding. After the sample is dried, put it in an acid mixture composed of 8% nitric acid, 7% hydrofluoric acid and 85% deionized water by volume and mass, and ultrasonically clean it for 20s, then wash it with deionized water for 5min, and repeatedly wash ...

Embodiment 3

[0083] This embodiment discloses the preparation method of the titanium material with in-situ growth of nano-hydroxyapatite on the surface of the present invention, specifically:

[0084] (1) Cleaning and pretreatment of materials: Cut the TA2 pure titanium with a filamentous crystal topological structure on the surface after rolling and heat treatment into the required structure and size, and perform ultrasonic cleaning with acetone, alcohol, and deionized water successively. Clean with each solvent for 30 minutes; then polish with 280-1500 mesh sandpaper, and then clean again according to the above cleaning steps. After the material is dried, place it in an acid mixture composed of 8% nitric acid, 5% hydrofluoric acid and 87% deionized water by volume and mass, and ultrasonically clean it for 40 seconds, then wash it with deionized water for 5 minutes, and repeatedly wash it with mixed acid, deionized water, etc. Rinse with deionized water 3 times, and finally dry.

[0085]...

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Abstract

The invention discloses a titanium material for in-situ growth of nano-hydroxyapatite on the surface, a preparation method and an application thereof, and belongs to the technical field of biomaterials. The titanium material with in-situ growth of nano-hydroxyapatite on the surface provided by the present invention, the base material is a titanium material whose surface has a contact induction effect on osteoblasts, and the Ca element and P element in the nano-hydroxyapatite covered on the base material The sum of the molar contents is less than or equal to 10%. The invention also provides the application of the titanium material with in-situ growth of nano-hydroxyapatite on the surface. The preparation method of the invention comprises: placing the base material with calcium ions chelated on the surface in a growth solution containing calcium ions and phosphate ions, and heating for reaction. The invention has low preparation cost, is not affected by the size and structure of the matrix material, can retain the original osteoinductive effect of the original matrix material, can improve its biological activity, enhance the proliferation and differentiation of osteoblasts on the surface, and can inhibit the growth of cancer cells. Proliferation and movement.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a titanium material, a preparation method and an application of nano-hydroxyapatite grown on the surface in situ. Background technique [0002] In the prior art, preparing a hydroxyapatite coating on the surface of a titanium-based material is a common method to improve its biological activity. However, there are two disadvantages in this method: on the one hand, the bonding strength between the coating with a thickness of micron and the matrix material and bone tissue does not match, which may easily cause the implant to fall off; on the other hand, the crystals of hydroxyapatite formed The particle size is difficult to form nanometer scale. Usually, the grain size in the hydroxyapatite coating formed by the plasma spraying method is at the micron level, and it will directly cover the surface of the base material, forming a coating of several microns to hundreds...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/32A61L27/50A61L27/54C01B25/32C22C14/00C23C18/12
CPCA61L27/06A61L27/32A61L27/50A61L27/306A61L27/54C23C18/1216C23C18/1241C22C14/00C01B25/32A61L2400/12A61L2430/02A61L2300/112A61L2300/412A61L2300/606C01P2004/03C01P2004/61
Inventor 聂宇王若涵金蓉蓉黄崇湘张兴栋
Owner SICHUAN UNIV
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