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Bifidobacterium lactis MN-Gup and application of microbial inoculum thereof in treatment of type 2 diabetes mellitus

A technology of bifidobacterium lactis and diabetes, applied in the application field of bifidobacterium MN-Gup and its bacterial agent in the treatment of type 2 diabetes, to achieve the effect of convenient consumption, high remission rate, and repair of intestinal mucosa

Active Publication Date: 2021-08-03
INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant report about a probiotic that specifically regulates type 2 diabetes-associated intestinal flora and restores healthy intestinal flora to improve, relieve or treat type 2 diabetes

Method used

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  • Bifidobacterium lactis MN-Gup and application of microbial inoculum thereof in treatment of type 2 diabetes mellitus
  • Bifidobacterium lactis MN-Gup and application of microbial inoculum thereof in treatment of type 2 diabetes mellitus
  • Bifidobacterium lactis MN-Gup and application of microbial inoculum thereof in treatment of type 2 diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The preparation of embodiment 1 bifidobacterium lactis MN-Gup bacterium powder

[0076] (1) Firstly, a strain named Bifidobacterium lactis MN-Gup was taken, which was deposited in the General Microbiology Center of China Committee for the Collection of Microorganisms, and the preservation number was CGMCC No.15578.

[0077] The method for obtaining the strain is as follows: 1) Bifidobacterium lactis BB-11 was isolated from healthy long-lived Bama elderly people in Guangxi, and preserved in the General Microbiology Center of China Committee for the Collection of Microbial Cultures, with the preservation number CGMCC No.14056;

[0078] (2) Bifidobacterium lactis BB-11 was carried on the "Shenzhou 11" returnable spacecraft, launched on October 17, 2016, and returned to the ground on November 18, 2016, and then screened and identified the mutagenic strains, A mutant strain with significantly higher oxygen tolerance than Bifidobacterium lactis BB-11, namely Bifidobacterium ani...

Embodiment 2

[0081] Example 2 Bifidobacterium lactis MN-Gup relieves type 2 diabetes and characteristic intestinal flora test

[0082] Get the Bifidobacterium lactis MN-Gup bacterium powder prepared in Example 1, the number of live bacteria is 3*10 11 cfu / g, used in this experiment.

[0083] 1. Improvement effect of Bifidobacterium lactis MN-Gup on T2DM mouse model

[0084] Select 60 male SPF grade C57BL / 6J male mice aged 6 weeks, and house all the mice in an animal room with a constant temperature of 21-25°C and a humidity of 40-70%, and the room maintains a 12-hour light / dark cycle. The breeding process complied with the relevant guidelines for the management and protection of experimental animals. Mice were first fed with common feed to adapt to the environment for 1 week (recorded as the first week of the experiment). Then they were randomly divided into 4 groups, 15 mice in each group, namely control group, model group, HFD+MN-Gup-low dose group and HFD+MN-Gup-high dose group. Con...

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Abstract

The invention belongs to the technical field, and particularly relates to application of bifidobacterium MN-Gup and a microbial inoculum thereof in treating type 2 diabetes mellitus. The invention provides bifidobacterium lactis MN-Gup or a microbial inoculum with a main component of bifidobacterium lactis MN-Gup, which can improve type 2 diabetes mellitus through a comprehensive mechanism, such as relieving islet injury, repairing intestinal mucosa, improving related inflammatory response, improving expression of intestinal insulin GLP-1, recovering intestinal flora health and the like. The problem that at present, a probiotic for specifically adjusting type 2 diabetes related intestinal flora and recovering healthy intestinal flora to improve, relieve or treat type 2 diabetes is lacked is solved.

Description

technical field [0001] The invention belongs to the technical field, and in particular relates to the application of a bifidobacterium MN-Gup and its bacterial agent in treating type 2 diabetes. Background technique [0002] Type 2 diabetes mellitus (T2DM) is a common metabolic disorder worldwide characterized by hyperglycemia due to insulin resistance and relative insulin deficiency. Metabolic abnormalities in T2DM may lead to multiple serious complications, such as cardiovascular disease, diabetic retinopathy, neuropathy, and nephropathy. Diabetes imposes a heavy burden on global health and is one of the leading causes of death worldwide. The gut microbiota plays an important role in the pathogenesis and metabolic disturbances of T2DM. [0003] The gut microbiota is a complex overall ecosystem, and the genome of the entire gut microbiota, known as the "microbiome," exceeds the human nuclear genome by at least 100-fold. Excessive intake of high-fat and fructose foods dis...

Claims

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Application Information

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IPC IPC(8): A61K35/745A61P3/10A61P1/00A61P5/50
CPCA61K35/745A61P3/10A61P1/00A61P5/50Y02A50/30
Inventor 陈建国韩雨婷孙二娜孙健康小红朱振华房洪涛史苏华
Owner INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD
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