Antibacterial gel containing sulfated polysaccharide-nano-silver complex and application of antibacterial gel

A sulfated polysaccharide and nano-silver technology is applied in the field of biomedicine to achieve good biocompatibility and safety, less irritation, and the effect of repairing the vaginal microenvironment

Pending Publication Date: 2021-08-13
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinically, there is still a lack of women's products that can be used to prevent and treat bacterial and viral infections at the same time.

Method used

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  • Antibacterial gel containing sulfated polysaccharide-nano-silver complex and application of antibacterial gel
  • Antibacterial gel containing sulfated polysaccharide-nano-silver complex and application of antibacterial gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Preparation of sulfated polysaccharide-nanometer silver complexes

[0033] Sulfated polysaccharide is a sulfated galactan extracted and purified from marine red algae. It is composed of sulfated and non-sulfated galactose connected alternately through α-1,3 glycosidic bonds and β-1,4 bonds. The sulfate group content is 18.5%.

[0034] The preparation method of the sulfated polysaccharide-nanometer silver complex is as follows: using galactan sulfate as a reducing agent and a stabilizer, reacting with a silver nitrate solution at a temperature of 60° C., adjusting the pH to 10, and magnetically stirring for 5 hours.

[0035] In the obtained sulfated polysaccharide-nanometer silver complex, the content of silver is 1300ppm.

[0036] 2. Preparation of antibacterial gel

[0037] Containing the antibacterial gel of sulfated polysaccharide-nano-silver complex, comprising the following components in mass percentage: carbomer 1%, sulfated polysaccharide-nano-silver complex...

Embodiment 2

[0043] 1. Preparation of sulfated polysaccharide-nanometer silver complexes

[0044] The sulfated polysaccharide is fucoidan sulfate extracted and purified from marine brown algae, and the sulfate group content is 29.3%.

[0045] The preparation method of sulfated polysaccharide-nano-silver complex is as follows: fucoidan sulfate is used as a reducing agent and a stabilizer, and silver nitrate solution is placed in a microwave reactor, and reduced for 10 minutes at a power of 300w to obtain sulfated polysaccharide- nanosilver complexes. In the obtained sulfated polysaccharide-nanometer silver complex, the content of silver is 1000ppm.

[0046] 2. Preparation of antibacterial gel

[0047] Containing the antibacterial gel of sulfated polysaccharide-nano-silver complex, comprising the following components in mass percentage: carbomer 2%, sulfated polysaccharide-nano-silver complex 5%, glycerin 5%, triethanolamine 2%, and the balance is water.

[0048] The preparation method a...

Embodiment 3

[0050] 1. Preparation of sulfated polysaccharide-nanometer silver complexes

[0051]Sulfated polysaccharides are alginate sulfates prepared from alginate through sulfation, and are formed by linking sulfated and non-sulfated β-D-mannuronic acid and α-L guluronic acid. The sulfate group content is 31.5%.

[0052] The preparation method of the sulfated polysaccharide-nanometer silver complex is as follows: use alginate sulfate as a reducing agent and a stabilizer, react with a silver nitrate solution at a temperature of 80° C., adjust the pH to 10, and stir magnetically for 1 hour. In the obtained sulfated polysaccharide-nanometer silver complex, the content of silver is 2000ppm.

[0053] 2. Preparation of antibacterial gel

[0054] The antibacterial gel containing sulfated polysaccharide-nano-silver complex includes the following components in mass percentage: carbomer 2%, sulfated polysaccharide-nano-silver complex 3%, glycerin 3%, triethanolamine 2%, and the balance of wate...

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Abstract

The invention discloses antibacterial gel containing a sulfated polysaccharide-nano silver complex and application of the antibacterial gel. The antibacterial gel comprises the following components of, in percentage by mass, 1%-10% of the sulfated polysaccharide-nano silver complex, 0.2%-5% of a gel matrix, 1%-5% of triethanolamine, 1%-10% of glycerol and the balance water. The antibacterial gel has excellent safety and biocompatibility, not only can effectively inhibit infection of bacteria such as escherichia coli, staphylococcus aureus and candida albicans, but also has an obvious inhibiting effect on infection of viruses such as human papilloma virus and herpes simplex virus, and therefore, the antibacterial gel can be applied to preparation of external medicines for preventing and treating gynecological diseases caused by pathogenic microorganism infection, and is small in irritation and good in use feeling and effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a bacteriostatic gel containing sulfated polysaccharide-nanometer silver complex and application thereof. Background technique [0002] Among the gynecological diseases caused by bacteria, bacterial vaginosis is the most common, not only has the highest incidence rate, but also has the highest recurrence rate. About 5 to 10 million women in my country suffer from vaginitis every year, and the incidence rate among married women of childbearing age is 42.1%. Gynecological diseases caused by viruses are the most common viral infections such as human papillomavirus (HPV) and herpes simplex virus (HSV). Cervical cancer is one of the four major malignant tumors in women all over the world, and its case fatality rate ranks second among female cancers. It is currently showing a trend of younger age. Cervical cancer is a representative of HPV infection-related diseases. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/06A61K47/10A61K47/18A61P31/04A61P31/10A61P31/20A61P31/22A61P15/02A61P15/00A61P37/04A61K31/737
CPCA61K31/737A61K33/38A61K9/06A61K9/0034A61K47/10A61K47/18A61P31/04A61P31/10A61P31/20A61P31/22A61P15/02A61P15/00A61P37/04A61K2300/00Y02A50/30
Inventor 李全才赵峡刘非陈祥艳刘浩管禄诗
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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