A temperature-sensitive gel damage repair preparation and its application

Abstract

The invention provides a temperature-sensitive gel damage repair preparation and application thereof, belonging to the technical field of biomedical preparations. The preparation includes 0.01-5mg / mL rHSA / EGF, 1.9%-2.6% glycine, 3.9%-6.2% poloxamer 188, 16.3%-18.2% poloxamer 407 and 0.5-100mM PB buffer. As an active ingredient, rHSA / EGF is beneficial to improve the repair of corneal and conjunctival damage, prevent, alleviate and treat dry eye syndrome, and at the same time guide the growth of skin cells and the repair of damaged skin; and the excipients can not only ensure the structural stability of the active ingredient, maintain Drug activity, while keeping the preparation in water form at 0~35°C, and gelatinous at ≥35°C, making the preparation stay longer in the application area, making it easier for the active ingredient to be released slowly, thereby improving the efficacy of the active ingredient Utilization rate, shorten medication time, improve repair speed.

Description

technical field [0001] The invention belongs to the technical field of biomedical preparations, and in particular relates to a temperature-sensitive gel damage repair preparation and its application. Background technique [0002] Dry eye can be called keratoconjunctival sicca (KCS) or xerophthalmia. The tear film instability and ocular surface damage caused by the quantity or quality of tears and abnormal fluid dynamics can lead to ocular symptoms and visual dysfunction, and long-term development can cause corneal epithelial damage. Common symptoms include eye dryness, foreign body sensation, and eye dryness syndrome. The patient's conjunctival goblet cell density decreases, the nucleus-to-plasma ratio increases, epithelial cells become squamous, corneal epithelial conjunctiva, and damage are urgently needed. Eye conjunctiva repair. Dry eye disease is now beginning to rejuvenate, that is, due to the application of computers and mobile phones among young people, a large num...

AI Technical Summary

Problems solved by technology

However, although the fusion protein injection can ensure the better efficacy of the fusion protein, it is not suitable for external administration, such as dry eye, keratitis, and corneal injury (the general term for cornea and conjunctival injury). Corneal repair after surgery is also It is a common clinical disease that requires drug intervention. At the same time, the administration of skin and epidermis damage is not suitable for injection, and it is suitable for external administration

However, traditional topical administration, such as eye drops and topical skin sprays for the eyes, is in the form of water, and after administration, only a small part of the drug can be absorbed locally, and most of the drug flows with gravity. Non-medication sites, which not only lead to the loss of drug efficacy, but also cause serious waste of drugs, which brings certain difficulties to the evaluation of drug efficacy and the determination of clinical treatment methods

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