Preparation method of cannabis sativa leaf extract water-soluble micro-capsule

A technology of extracts and cannabis leaves, which is applied in the field of preparation, can solve the problems of poor solubility and stability of cannabidiol, and achieve the effects of improving bioavailability and effect, good dispersion, and improving solubility and stability

Pending Publication Date: 2021-08-17
哈尔滨市汉博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of poor solubility and poor stability of cannabidiol in the cannabis leaf extract microcapsules obtained by the existing method, and to provide a preparation method of the cannabis leaf extract water-soluble microcapsules

Method used

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  • Preparation method of cannabis sativa leaf extract water-soluble micro-capsule
  • Preparation method of cannabis sativa leaf extract water-soluble micro-capsule
  • Preparation method of cannabis sativa leaf extract water-soluble micro-capsule

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specific Embodiment approach 1

[0020] Embodiment 1: This embodiment is a method for preparing water-soluble microcapsules of cannabis leaf extract, which is specifically completed according to the following steps:

[0021] 1. Wall material preparation: ①, emulsifier preparation; disperse glyceryl monostearate in hot distilled water to obtain emulsifier; Essence and gum arabic are added to the emulsifier, and mixed to obtain the wall material mixture;

[0022] 2. Core material preparation: dissolve the cannabis leaf extract in caprylic capric acid glyceride, and mix to obtain the core material mixture;

[0023] 3. Forming: Add distilled water to the core material mixture, then add the wall material mixture, first use a high-speed shearing machine for rough shearing, then high-pressure homogenize for 1 to 3 times, and finally spray dry to obtain a water-soluble cannabis leaf extract Microcapsules.

[0024] β-cyclodextrin has a hole in the center of the ring structure, and there is an oxygen atom in which -C...

specific Embodiment approach 2

[0027] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is: the mass ratio of glyceryl monostearate described in step 1. to hot distilled water is (2~5)g:(25~30) mL. Others are the same as the first embodiment.

specific Embodiment approach 3

[0028] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the mass ratio of β-cyclodextrin and gum arabic described in step 1② is (10~20):1; the arabic The mass ratio of glyceryl monostearate in the gum to the emulsifier is (1-2):1. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a cannabis sativa leaf extract water-soluble micro-capsule, and relates to a preparation method of a water-soluble micro-capsule. The invention aims to solve the problems of poor cannabidiol solubility and poor stability of the cannabis sativa leaf extract micro-capsule obtained by an existing method. The preparation method comprises the following steps: 1, preparing a wall material to obtain a wall material mixture; 2, preparing a core material to obtain a core material mixture; and 3, forming: carrying out rough shearing by adopting a high-speed shearing machine, carrying out high-pressure homogenization, and finally carrying out spray drying to obtain the cannabis sativa leaf extract water-soluble micro-capsule. The preparation method has the advantages that the solubility and the stability of the active ingredient cannabidiol are obviously improved, so that the bio-availability and the acting effect of cannabidiol are improved, the oxidation resistance of cannabidiol is improved, and the storage time is longer. The cannabis sativa leaf extract water-soluble micro-capsule can be used for preparing spices, solid beverages, milk beverages and liquid beverages.

Description

technical field [0001] The invention relates to a preparation method of water-soluble microcapsules. Background technique [0002] Cannabidiol is a non-toxic, high-value-added phenolic substance extracted from industrial hemp flowers and leaves that can be used in food, cosmetics and medicine. At present, developed countries such as Israel, the United States, and the United Kingdom have used it as a raw material and developed a variety of special effects drugs and cosmetics. Cannabidiol is a non-addictive component in industrial hemp (THC is less than 0.3%), which can hinder THC from affecting the human body. It affects the human nervous system, and has pharmacological activities such as anti-spasmodic, anti-rheumatic arthritis, and anti-anxiety, but phenolic substances are easily oxidized by oxygen in the air and basically insoluble in water. Their stability and release during product use sex, there are deficiencies. Purified cannabidiol is only approved for the treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23P10/30A23L29/10A23L27/10A23L2/52A23F3/14A23F3/30A23C9/152A61K9/50A61K31/05A61K36/60A61K47/69A61K47/14A61P39/06A61P37/04A61P29/00A61P39/02A61P25/20A61P37/02A61P19/02A61P25/22A61K8/34A61K8/9789A61K8/37A61K8/73A61Q19/08B01J13/02A61K127/00
CPCA23L33/105A23P10/30A23L29/10A23L27/10A23L2/52A23F3/14A23F3/30A23C9/152A61K9/5015A61K9/5036A61K47/14A61K31/05A61K36/60A61P39/06A61P37/04A61P29/00A61P39/02A61P25/20A61P37/02A61P19/02A61P25/22A61K8/347A61K8/9789A61K8/375A61K8/738A61Q19/08B01J13/02A23V2002/00A61K2236/15A61K2236/17A61K2236/37A61K2236/55A23V2200/30A23V2250/21A23V2200/222A23V2250/192A23V2250/5112A23V2250/5028
Inventor 孙秋君彭禹贾光远
Owner 哈尔滨市汉博生物科技有限公司
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