Adsorption material for blood perfusion and preparation method thereof
A hemoperfusion and adsorption material technology, applied in chemical instruments and methods, other chemical processes, dialysis systems, etc., can solve the problems of high environmental cost, hemocompatibility of adsorption materials, complex production process of adsorption materials, etc., to achieve good adsorption, The effect of high strength and low hemolysis rate
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[0039] A preparation method of an adsorbent material for hemoperfusion of the present invention comprises the following steps:
[0040] S1. Suspension polymerization is adopted. Specifically, a certain amount of pure water is added to the reactor, and a dispersant and a water phase polymerization inhibitor are put in, and each component is completely dissolved at 45°C to form a water phase;
[0041] The mass ratio of pure water: dispersant: water phase polymerization inhibitor is 100: (0.5 ~ 1.5): (0.0005 ~ 0.0015), the dispersant is gelatin, sodium carboxymethyl cellulose, and the water phase polymerization inhibitor is methylene blue.
[0042] S2. Prepare the monomer, initiator and porogen according to the process requirements, and stir until completely dissolved to form an oil phase;
[0043] The mass ratio of monomer: initiator: porogen is 100: (0.5-1.5): (100-250).
[0044] The monomer includes one or more of divinylbenzene and styrene, methyl styrene, methyl acrylate, m...
Embodiment 1
[0053] Prepare the oil phase in a beaker: 80g divinylbenzene (content 80%), 5g methyl acrylate, 15g styrene, 100g n-heptane and 0.5g benzoyl peroxide, and stir evenly.
[0054] Add 500ml of water, 3g of gelatin, 0.5g of sodium carboxymethyl cellulose and 5ml of 0.1% methylene blue solution into a 1-liter three-necked flask to completely dissolve each component at 45°C to form a water phase solution, and add the oil phase solution to the water In the phase solution, let it stand for 5 minutes, turn on the stirring, adjust the stirring speed to control the particle size, raise the temperature to 65°C at 5°C / 10min for 3 hours, and react at 85°C for 15 hours.
[0055] After the reaction, filter the mother liquor, add the macroporous adsorption resin to the extraction column, and recover the porogen n-heptane by steaming at 100°C until the outlet condensate contains almost no oil, stop steaming, cool down, wash with a large amount of water, sieve Separate and discharge to obtain a ...
Embodiment 2
[0057] Prepare the oil phase in a beaker: 80g divinylbenzene (content 80%), 5g methyl acrylate, 15g methylstyrene, 150g tetramethylbenzene and 1.0g benzoyl peroxide, and stir evenly.
[0058] Add 500ml of water, 5g of gelatin, and 10ml of 0.1% methylene blue solution into a 1-liter three-neck flask to completely dissolve each component at 45°C to form a water phase solution, add the oil phase solution to the water phase solution, and let it stand for 5 minutes , start stirring, adjust the stirring speed to control the particle size, raise the temperature at 5°C / 10min to 65°C for 6 hours, and react at 80°C for 10 hours to recover tetramethylbenzene.
[0059] After the reaction, filter the mother liquor, add the macroporous adsorption resin to the extraction column, and recover the porogen tetramethylbenzene by steaming at 105°C until the outlet condensate contains almost no oil, stop steaming, cool down, wash with a large amount of water, and sieve , and discharged to obtain a ...
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