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PEG styptic powder

A hemostatic powder, PEG-1 technology, applied in medical science, drug delivery, bandages, etc., can solve the problems of no interaction between tissues, easy to break, and low strength of colloids, and achieve good biocompatibility and increased strength Effect

Inactive Publication Date: 2021-08-20
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the jelly formed by the hemostatic powder is not strong enough and is easily broken under the impact of the blood flow at the wound; the hemostatic powder does not interact with the tissue at the wound, and must be specially fixed during use, resulting in inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The synthesis of four-arm polyethylene glycol aldehyde group is as follows [1] : P-aldehyde benzoic acid (150mg, 10eq.), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (191.7mg, 10eq.) and 4-dimethylamino Pyridine (61.08mg, 5eq.) was dissolved in 50ml of anhydrous dichloromethane, four-armed polyethylene glycol (1g, 1eq.) was added and reacted at room temperature for 24 hours. Then the solution after the reaction was extracted and washed with 1M hydrochloric acid (3×40mL), saturated sodium bicarbonate (3×40mL), and saturated brine (3×40mL) respectively, and the organic layer was collected after washing, and then anhydrous MaSO 4 Drying, filtering, and rotary evaporation to remove the solvent, the final product was dried in a vacuum oven with a yield of 90%. 1 H NMR (300MHz, CDCl 3 ): δ3.25(t, 8H; CH 2 ), 3.64 (bs, ~1000H; OCH 2 CH 2 O), 3.85(s, 8H; CH 2 CH 2 OCO), 4.61(s, 8H; CH 2 OCO), 7.95 (m, 8H; Ar-H), 8.24 (m, 8H; Ar-H), 10.03 (m, 4H; CHO); 13...

Embodiment 2

[0046] Take by weighing 200mg four-arm polyethylene glycol amino (as shown in formula II, wherein, n is 112, R 1 is amino), weigh 200mg eight-arm polyethylene glycol succinimide succinimide ester group (as shown in formula IV, wherein, n is 112, R 1 It is succinimide ester group of succinate), and after mixing evenly with a vibrator, the water absorption rate of the system is 45 times.

[0047] According to the method in Example 1, the adhesion strength measured by a universal tensile machine was 46Kpa.

[0048] The degradation performance of the hydrogel prepared in this example was tested according to the method in Example 1, and the degradation time was measured to be 3 days.

Embodiment 3

[0050] Take by weighing 100mg eight-arm polyethylene glycol glutaric acid succinimide ester (as shown in formula IV, wherein, n is 56, R 1 is glutaric acid succinimide ester group), weighed 200mg four-arm polyethylene glycol mercapto (as shown in formula II, wherein, n is 48, R 1 for mercapto), using a shaker to mix evenly, and the water absorption rate is 54 times.

[0051] According to the method in Example 1, the adhesion strength of the system was measured by a universal tensile machine to be 39kPa, which indicated that the gel could be well attached to the surface of pigskin.

[0052] The degradation performance of the hydrogel prepared in this example was tested according to the method in Example 1, and the degradation time was measured to be 10 days.

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Abstract

The invention provides a PEG styptic powder system based on controllable crosslinking and degradation and a preparation method and application thereof. The styptic powder is composed of PEG-1 and PEG-2, and the PEG-1 and the PEG-2 can react with each other in the presence of blood to form gel, so that the strength of the styptic powder and the interaction capacity of the styptic powder and tissues are enhanced. The PEG styptic powder can absorb a large amount of water, and the degradation time can be adjusted, so that the PEG styptic powder adapts to different bleeding positions and bleeding degrees.

Description

technical field [0001] The invention relates to a hemostatic powder system, in particular to a hemostatic powder system based on a controllable cross-linking and degradable PEG powder, and a preparation method and application thereof. Background technique [0002] For a long time, traditional methods of hemostasis such as ligation, suture, electrocoagulation, absorbable hemostatic clips and tourniquets not only increase the difficulty of surgery for medical workers, but also affect the surgical field of vision and cause hidden dangers of medical accidents. In recent years, various materials have been developed for the hemostatic seal, including hemostatic powder, hemostatic gel, hemostatic bandage, and so on. For hemostatic gel, it is difficult to apply the gel on the surface of the wound under the washing of a large blood flow, which seriously limits their application; for the hemostatic bandage, it cannot be applied to irregularly shaped wounds, and cannot seal deep wounds...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0061A61L2400/04C08L71/00
Inventor 吴德成叶慧君潘正
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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