Phenothiazine-containing iridium complex as well as preparation method and application thereof

A technology of phenothiazine iridium and iridium complexes, which is applied in the field of phenothiazine iridium complexes and their preparation, can solve the problems of low efficiency and achieve strong tissue penetration, small light damage, and low background autofluorescence Effect
CN113278036AActive Publication Date: 2021-08-20GANNAN NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
GANNAN NORMAL UNIV
Publication Date
2021-08-20

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Abstract

The invention provides a phenothiazine-containing iridium complex as well as a preparation method and application thereof, and belongs to the technical field of photosensitizers. On the basis that a central iridium atom of the metal iridium complex is a heavy atom, the long-life triplet excitation state of the metal iridium complex is regulated and controlled through phenothiazine, the emission spectrum of the designed iridium complex containing the phenothiazine structure is located in a near-infrared region, and the iridium complex belongs to near-infrared phosphorescence emission iridium complexes. The phenothiazine structure is introduced into the N^N ligand of the iridium complex, so that the capability of generating <1>O2 by the iridium complex can be improved. The iridium complex provided by the invention can generate singlet oxygen in both a solution and tumor cells under the illumination condition of more than 470nm, has the capability of photodynamically killing cancer cells, and provides possibility for photodynamic therapy.
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Description

Technical field

[0001] The present invention relates to the field of photodynamic therapy, particularly to a phenothiazine-containing iridium complex and its preparation method and application. Background technique

[0002] Phosphorescent iridium metal complex depends on the ligands and the metal center so that it is excited, iridium complexes led to strong spin-orbit coupling of the tri-state mixing singlet, which makes it has excellent photophysical properties, including good light stability , high quantum yield, a large Stokes shift and a long phosphorescence life. Since iridium (III) complexes have a triplet excited state, the triplet excited state energy transfer occurs with molecular oxygen in the surrounding, can induce cytotoxic activity of singlet oxygen is oxygen. Therefore, the iridium complex can be used as photosensitizers in photodynamic therapy, directly or indirectly kills cancer cells under light irradiation.

[0003] In recent years, due to the central iridium c...

Claims

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