Novel composite bone cement with biological activity

A technology of biological activity and bone cement, applied in the direction of phosphorus compounds, tissue regeneration, inorganic chemistry, etc., can solve the problems of loss of modification effect, failure to obtain high-performance bone cement materials, deterioration of matrix mechanical properties, etc., to shorten the deposition period, Improved mechanical properties and good biological activity

Inactive Publication Date: 2021-08-24
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active material inside the PMMA matrix loses its modification effect, and the method of increasing the amount of addition in order to shorten the osteogenesis period will deteriorate the m

Method used

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  • Novel composite bone cement with biological activity
  • Novel composite bone cement with biological activity
  • Novel composite bone cement with biological activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A new type of composite bone cement with biological activity and enhanced mechanical properties. The raw materials include powder and liquid. The powder contains 39% polymethyl methacrylate (PMMA) microspheres and 15% zirconium dioxide ( ZrO 2 ), 3% benzoyl peroxide (BPO), 2% gentamicin sulfate, 41% strontium magnesium co-doped hydroxyapatite whiskers (SrMg-HAPw), the liquid contains 98% by mass percentage % of methyl methacrylate (MMA), 2% of N,N-dimethyl-p-toluidine (DmpT); after the powder is weighed according to the proportion of the above-mentioned raw materials, continue stirring with a spatula until uniform, powder, liquid After mixing according to the mixing ratio of 1.0g / mL, the new composite bone cement was obtained through stirring, standing, shaping and curing.

[0042] The weight-average molecular weight M of the polymethyl methacrylate (PMMA) microsphere that present embodiment uses w 120000, number average molecular weight M n 96000, the size range of ...

Embodiment 2

[0051] A new type of composite bone cement with biological activity and enhanced mechanical properties. The raw materials include powder and liquid. The powder contains 84.3% polymethyl methacrylate (PMMA) microspheres, 5% barium sulfate (BaSO 4 ), 0.5% benzoyl peroxide (BPO), 0.2% gentamicin sulfate, 10% strontium magnesium co-doped hydroxyapatite whisker (SrMg-HAPw), the liquid contains 99.6% by mass percentage % of methyl methacrylate (MMA), 0.4% of N, N-dimethyl-p-toluidine (DmpT); after the powder is weighed according to the proportion of the above-mentioned raw materials, it is continuously stirred with a spatula until uniform, and the powder, liquid After mixing according to the mixing ratio of 3.0g / mL, the new composite bone cement was obtained through stirring, standing, shaping and curing.

[0052] The weight-average molecular weight M of the polymethyl methacrylate (PMMA) microsphere that present embodiment uses w 50000, number average molecular weight M n is 2500...

Embodiment 3

[0059] A new type of composite bone cement with biological activity and enhanced mechanical properties. The raw materials include powder and liquid. The powder contains 66.2% polymethyl methacrylate (PMMA) microspheres, 7% barium sulfate (BaSO 4 ), 1% benzoyl peroxide (BPO), 1.5% gentamicin sulfate, 24.3% strontium magnesium co-doped hydroxyapatite whiskers (SrMg-HAPw), the liquid contains 98.3% by mass percentage % of methyl methacrylate (MMA), 1.7% of N, N-dimethyl-p-toluidine (DmpT); after the powder is weighed according to the proportion of the above-mentioned raw materials, continue stirring with a spatula until uniform, powder, liquid After mixing according to the mixing ratio of 2.2g / mL, the new composite bone cement was obtained through stirring, standing, shaping and curing.

[0060] The weight-average molecular weight M of polymethyl methacrylate (PMMA) microspheres w 100000, number average molecular weight M n is 50000, and the size range of microspheres is 15-27 ...

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Abstract

The invention discloses novel composite bone cement with biological activity, raw materials comprise powder and liquid, the powder comprises the following parts in percentage by mass: 39%-84.3% of polymethyl methacrylate microspheres, 5%-15% of zirconium dioxide, 0.5%-3% of benzoyl peroxide, 0.2%-2% of gentamicin sulfate and 10%-41% of strontium-magnesium co-doped hydroxyapatite whiskers, The liquid comprises the following parts in percentage by mass: 98-99.6% of methyl methacrylate and 0.4-2% of N, N-dimethyl p-toluidine, mixing the powder and the liquid, stirring, standing, shaping and curing to obtain the novel composite bone cement. Bone-like apatite can be induced to be deposited on the surface of the bone cement in in-vitro simulated human body fluid, new bones can be promoted to grow on the interface of the bone cement and bone tissues in animal model rabbit bodies, good biological activity and osteogenesis promoting capacity are shown, and the compressive strength, bending strength and bending elastic modulus of the bone cement are all higher than those of conventional bone cement.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a novel composite bone cement with good biological activity, which can induce the nucleation and deposition of bone-like apatite in simulated human body fluid in vitro, and can promote the growth of new bone in vivo. The interface between bone cement and bone tissue is replaced by mechanical linkage to osseointegration, thereby reducing aseptic inflammation and loosening, and prolonging the service life of the joint prosthesis in the human body. Background technique [0002] After years of clinical practice and postoperative follow-up, the conventionally used polymethyl methacrylate (PMMA) bone cement has certain performance defects, mainly as follows: it does not degrade itself, has poor fusion with surrounding bone tissue, and relies on mechanical interlocking. Connected with bone tissue, this physical connection mechanism is prone to failure when the material is def...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/04A61L27/02A61L27/16A61L27/50A61L27/54C01B25/32
CPCA61L27/12A61L27/047A61L27/025A61L27/16A61L27/50A61L27/54C01B25/321A61L2430/24A61L2430/02A61L2300/102A61L2300/112A61L2300/412C01P2002/72C01P2004/03C01P2002/85C01P2004/04C01P2002/82C01P2002/77C08L33/12
Inventor 刘金坤徐杉陈庆华朱艳孙淑红
Owner KUNMING UNIV OF SCI & TECH
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