Preparation method of sodium valproate sustained release tablet

A technology of sodium valproate and sustained-release tablets, which is applied in the field of medicine, can solve the problems of easy spherical shape, low moisture content, slow particle growth, etc., and achieve the effect of overcoming the consequences of collapsed bed.
CN113304117AActive Publication Date: 2021-08-27YANGTAI PHARMA SHANDONG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANGTAI PHARMA SHANDONG
Publication Date
2021-08-27

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Abstract

The invention discloses a preparation method of a sodium valproate sustained release tablet, and belongs to the technical field of medicines. The sodium valproate sustained-release tablet disclosed by the invention consists of active medicines, namely valproic acid, sodium valproate, a flavoring agent, a framework material, a retardant, a lubricant, an adsorbent and a gastric-soluble coating premix. According to the preparation method of the sodium valproate sustained release tablet, the problem that sodium valproate in the product is not beneficial to industrial production due to extremely high hygroscopicity is solved, the hygroscopicity characteristic of the sodium valproate is utilized, the humidity in a fluidized granulator is increased to form granules in the fluidization process, the prepared granules have good flowability and tabletability, and the prepared product has good stability, has good similarity between in-vitro dissolution and original dissolution curves, and is suitable for large-scale production.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation method of a sodium valproate sustained-release tablet. Background technique

[0002] Sodium valproate is white crystalline powder or granules; it has strong hygroscopicity. This product is easily soluble in water, easily soluble in methanol or ethanol, and almost insoluble in acetone. Chemical name: sodium 2-propyl valerate.

[0003] Chemical Structure:

[0004]

[0005] Sodium valproate is an anti-seizure drug that is also used to treat mania. It can be used for epilepsy monotherapy or as an add-on therapy. For the treatment of generalized epilepsy: including absence seizures, myoclonic seizures, tonic-clonic seizures, atonic seizures and mixed seizures, special types of syndromes (West, Lennox-Gastaut syndrome), etc. For the treatment of partial epilepsy: Partial seizures, with or without generalized seizures. It can also be used to treat manic episodes ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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