Pharmaceutical composition with effect of improving depressive symptoms and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of poor treatment effect and high cost, and achieve the effects of flexible use, memory improvement and anxiety improvement

Active Publication Date: 2021-09-03
四川省食用菌研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Pharmaceutical composition with effect of improving depressive symptoms and preparation method thereof
  • Pharmaceutical composition with effect of improving depressive symptoms and preparation method thereof
  • Pharmaceutical composition with effect of improving depressive symptoms and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

reference example 1

[0093] The preparation of reference example 1 Flammulina velutipes killing green water extract

[0094] The preparation method of Flammulina velutipes green-fixing water, comprises the following steps:

[0095] Put 0.3 tons of Flammulina velutipes into 1 ton of 100°C boiling water for 3 minutes and then take it out, then put 0.3 tons of Flammulina velutipes into it for greening. Repeat the above operations until 3 tons of Flammulina velutipes are finished greening, filter under reduced pressure, collect the greening water, and use a texture analyzer (brand SMS, place of origin UK, model TA.XT PLUS) to detect the viscosity of the greening water to be 1500cp.

[0096] The preparation method of Flammulina velutipes killing green water extract comprises the following steps:

[0097] (1) Filter 1000ml Flammulina velutipes greening water with two layers of gauze, collect filter residue and filtrate;

[0098] (2) Add 5% maltodextrin to the filtrate and stir for 10 minutes to obtai...

Embodiment 1

[0102] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0103] The composition of the pharmaceutical composition:

[0104]

[0105] The preparation method of composition comprises the following steps:

[0106] Weighing required amount of enoki mushroom greening water extract, dissolving it in 0.1-2% sodium alginate solution to prepare mixed solution as wall material. Add the prepared wall material into the syringe, install it on the microcapsule granulator, and use another high-temperature sterilized pressure bottle to fill the probiotic spore as the core material. Select a suitable diameter concentric nozzle (0.50mm) according to the requirement of granulation size. Installed at the bottom of the instrument with magnetic stirring and filled with 0.1-2% CaCl 2 glass with solution. Turn on the power of the microcapsule granulator, gradually increase the vibration frequency and the voltage of the electrostatic device to high-frequenc...

Embodiment 2

[0107] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0108] The composition of the pharmaceutical composition:

[0109]

[0110] The preparation method of composition comprises the following steps:

[0111] Weighing required amount of enoki mushroom greening water extract, dissolving it in 0.1-2% sodium alginate solution to prepare mixed solution as wall material. Add the prepared wall material into the syringe, install it on the microcapsule granulator, and use another high-temperature sterilized pressure bottle to load Lactobacillus casei as the core material. Select a suitable diameter concentric nozzle (0.50mm) according to the requirement of granulation size. Installed at the bottom of the instrument with magnetic stirring and filled with 0.1-2% CaCl 2 glass with solution. Turn on the power of the microcapsule granulator, gradually increase the vibration frequency and the voltage of the electrostatic device to high-frequen...

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Abstract

The invention relates to a pharmaceutical composition capable of improving depressive symptoms. The composition is prepared from 50-80% of a flammulina velutipes enzyme-deactivated water extract, 1-3% of theanine, 1-10% of probiotics, 5-30% of prebiotics, 5-10% of sugar substitutes and a pharmaceutically acceptable carrier. The composition has the beneficial effects of well improving depressive symptoms, improving sleep, improving anxiety, improving memory, enhancing immunity and the like.

Description

technical field [0001] The invention relates to the field of medicine, and relates to a pharmaceutical composition with the effect of improving depression symptoms, a preparation method and application thereof. Background technique [0002] In order to better retain the color, fragrance, taste and nutritional components of Flammulina velutipes, in industrial production, Flammulina velutipes is often placed in boiling water for instant heating to kill, so as to destroy and inhibit the enzyme activity in Flammulina velutipes and prevent the oxidative degradation of nutrients in the process of processing Flammulina velutipes And change color and taste, reduce the total number of bacteria and avoid bacterial contamination. Flammulina velutipes water contains rich nutrients and high content of gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter in the brain. Studies have shown that increasing the activity of GABA neurons in depression model mice promotes the ...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61K36/752A61P25/24A61P25/22A61P25/20A61P25/28A61P37/04A61K31/198A61K35/741A61K35/747A61K35/742A61K35/745A61K35/744A61K31/733A61K31/702A61K31/7016A61K31/7004A61K31/718A61K31/704A61K31/047A61K31/7032A61K31/137A61K31/4525A61K31/15A61K31/343
CPCA61K36/07A61K31/198A61K35/741A61K35/747A61K36/064A61K35/742A61K35/745A61K35/744A61K36/752A61K31/733A61K31/702A61K31/7016A61K31/7004A61K31/718A61K31/704A61K31/047A61K31/7032A61K31/137A61K31/4525A61K31/15A61K31/343A61P25/24A61P25/22A61P25/20A61P25/28A61P37/04A61K2300/00
Inventor 许瀛引谢丽源张志远周洁唐杰何晓兰陈影彭卫红王勇
Owner 四川省食用菌研究所
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