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Copper-aluminum film electrode for enzyme-free glucose sensor and its preparation method and application

A technology of glucose sensor and thin film electrode, applied in the direction of instruments, scientific instruments, material electrochemical variables, etc., can solve the problems of poor particle uniformity, strong uncontrollability, complex operation, etc., to reduce detection limit, improve sensitivity and linearity , the effect of shortening the response time

Active Publication Date: 2021-10-26
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the preparation method of the above enzyme-free glucose sensor has high cost, strong uncontrollability, complicated operation, poor particle uniformity, and is not suitable for large-scale production.

Method used

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  • Copper-aluminum film electrode for enzyme-free glucose sensor and its preparation method and application
  • Copper-aluminum film electrode for enzyme-free glucose sensor and its preparation method and application
  • Copper-aluminum film electrode for enzyme-free glucose sensor and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Start the main power of the magnetron sputtering apparatus and turn on the cooling water. After the pressure in the sputtering chamber is balanced with the atmospheric pressure, manually adjust the target base distance to a reasonable value and fix the clean silicon wafer on the sample stage. Install the Cu target on the target position of the DC power supply, install the Al target on the target position of the RF power supply, close the door of the sputtering chamber, seal the sputtering chamber, and then evacuate the sputtering chamber. First turn on the mechanical pump and side pumping valve, evacuate to below 0.1Pa, then turn off the mechanical pump and side pumping valve. Then turn on the molecular pump, fore valve and gate valve in turn until the vacuum degree reaches 5Í10 -4 After Pa is below, open the inlet valve, set the flow rate of argon gas to 40 sccm, and then pass argon gas into the sputtering chamber. Adjust the gate valve so that the coating pressure is...

Embodiment 2

[0058] The CuAl prepared by embodiment 1 2 The intermetallic compound was placed in 0.01mol / L NaOH solution, and the CuAl 2 The intermetallic compound is electrochemically corroded, the voltage of the electrochemical corrosion is 0.5V, and the corrosion time is 450s. During the voltage corrosion process, the Al on the surface is consumed by reactive corrosion in NaOH solution. Thus, a copper-aluminum thin film electrode is obtained.

Embodiment 3

[0060] The CuAl prepared by embodiment 1 2 The intermetallic compound was placed in 0.1mol / L NaOH solution, and the CuAl 2 The intermetallic compound is electrochemically corroded, the voltage of the electrochemical corrosion is 0.5V, and the corrosion time is 450s. During the voltage corrosion process, the Al on the surface is consumed by reactive corrosion in NaOH solution. Thus, a copper-aluminum thin film electrode is obtained.

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Abstract

The invention provides a copper-aluminum film electrode, the copper-aluminum film electrode is made of CuAl 2 Composed of intermetallic compounds; the surface of the copper-aluminum film electrode is loaded with CuAl 2 Nanorods composed of intermetallic compounds; the surface of the nanorods is loaded with nanoscale copper foam. The enzyme-free glucose sensor obtained by using the copper-aluminum film electrode provided by the invention as the working electrode of the glucose sensor has high sensitivity, high linearity, low detection limit and short response time, and can realize long-term continuous measurement of blood sugar.

Description

technical field [0001] The invention relates to the field of working electrodes, in particular to the field of working electrodes of glucose sensors. Background technique [0002] At present, most clinical and household blood glucose meters use electrochemical glucose sensors based on glucose oxidase, but the stability of such glucose sensors is poor. The main reason is that the glucose biosensor needs to use a glucose oxidase that is sensitive to environmental changes. Glucose oxidase promotes the redox reaction of glucose and oxygen to produce gluconic acid and hydrogen peroxide (H 2 o 2 ), by detecting H 2 o 2 content to obtain the glucose concentration in the blood. However, the temperature stability of glucose oxidase is poor, and the action temperature of glucose oxidase is generally 30-60°C, and it is easy to lose activity at other temperatures. Moreover, glucose oxidase has high requirements on the acidity and alkalinity of the working environment, and the stab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327G01N27/30C23C14/35C23C14/16C23C14/58
CPCG01N27/327G01N27/301C23C14/35C23C14/165C23C14/5873
Inventor 杨斌张婷殷雨晴
Owner HUNAN UNIV
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