Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Combined artificial blood vessel and preparation method thereof

An artificial blood vessel and combined technology, applied in the field of artificial blood vessels, can solve the problems of biological incompatibility, difficult operation and high risk, and achieve the effect of reducing the difficulty of operation, reducing the risk of operation and high biocompatibility.

Pending Publication Date: 2021-09-17
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some disadvantages in the artificial blood vessels currently used in clinical practice. On the one hand, for some people with special constitutions, artificial blood vessels made of polymer materials will have side effects such as biological incompatibility and rejection, which will endanger their health; On the one hand, the plasticity of the existing artificial blood vessels is relatively poor, and the adaptability to some special diseases such as lesions at the intersection of blood vessels is poor, and the operation is difficult and risky

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Combined artificial blood vessel and preparation method thereof
  • Combined artificial blood vessel and preparation method thereof
  • Combined artificial blood vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] A method for preparing a combined artificial blood vessel, comprising:

[0058] Step 1. Put s parts of silk, f parts of spider silk, 5-8 parts of chitosan, and sodium carbonate solution in a heating device and heat to 100-120°C, then add 1-3 parts of cross-linking agent and keep warm for 10-20 minutes , to obtain a mixed silk protein solution;

[0059] Step 2, repeatedly washing the mixed silk protein solution with methanol to obtain mixed silk protein;

[0060] Step 3. Put 10-20 parts of polyamide fiber, 12-26 parts of polyester fiber, 80-110 parts of mixed silk protein and spinning solution in a container, place the container in an ultrasonic machine, and ultrasonically vibrate to obtain uniform dispersion The composite solution, the spray rate curve of ultrasonic vibration is:

[0061]

[0062] Among them, p 0 is the average vibration frequency, and t is the vibration time.

[0063] Step 4: Spin the composite solution in a spinning machine to obtain a composit...

experiment example 1

[0067] Step 1. Put 16 parts of silk, 89 parts of spider silk, 5 parts of chitosan, and sodium carbonate solution in a heating device and heat to 100°C, then add 1 part of crosslinking agent and keep it warm for 15 minutes to obtain a mixed silk protein solution;

[0068] Step 2, repeatedly washing the mixed silk protein solution with methanol to obtain mixed silk protein;

[0069] Step 3. Put 10 parts of polyamide fiber, 12 parts of polyester fiber, 110 parts of mixed silk protein and spinning solution in a container, put the container in an ultrasonic machine, and ultrasonically oscillate to obtain a uniformly dispersed composite solution, and ultrasonically oscillate The spray rate curve is:

[0070]

[0071] Among them, p 0 is the average vibration frequency of 20 times / min, and t is the vibration time of 2h.

[0072] Step 4: Spinning the composite solution in a spinning machine to obtain a composite rubber filament, the spinning parameters are spinning voltage 120kv, ...

experiment example 2

[0076] Step 1. Put 55 parts of silk, 35 parts of spider silk, 8 parts of chitosan, and sodium carbonate solution in a heating device and heat to 100°C, then add 3 parts of crosslinking agent and keep it warm for 15 minutes to obtain a mixed silk protein solution;

[0077] Step 2, repeatedly washing the mixed silk protein solution with methanol to obtain mixed silk protein;

[0078] Step 3. Put 20 parts of polyamide fiber, 26 parts of polyester fiber, 100 parts of mixed silk protein and spinning solution in a container, place the container in an ultrasonic machine, and ultrasonically vibrate to obtain a uniformly dispersed composite solution, and ultrasonically vibrate The spray rate curve is:

[0079]

[0080] Among them, p 0 is the average vibration frequency of 20 times / min, and t is the vibration time of 2h.

[0081] Step 4: Spinning the composite solution in a spinning machine to obtain a composite rubber filament, the spinning parameters are spinning voltage 120kv, l...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
angleaaaaaaaaaa
Login to View More

Abstract

The invention discloses a combined artificial blood vessel. The combined artificial blood vessel comprises a main blood vessel, a branch blood vessel, and an intravascular stent; the main blood vessel is provided with at least one connecting hole; one end of the branch blood vessel is detachably connected with s connecting hole of the main blood vessel and can communicate with the main blood vessel; and the intravascular stent is elastically supported at the connecting hole of the main blood vessel. The main blood vessel and the branch blood vessel are both composite collodion silk braided tubes, and composite collodion silk is prepared from the following components in parts by mass: s parts of cocoon silk, f parts of spider silk, 5-8 parts of chitosan, 10-20 parts of polyamide fiber, 12-26 parts of polyester fiber and 1-3 parts of a cross-linking agent. According to the combined artificial blood vessel, the cocoon silk and the spider silk are used as main raw materials to prepare the composite collodion silk braided tubes, the composite collodion silk braided tubes are used as materials for preparing the combined artificial blood vessel, the strength and the toughness are high, the biocompatibility is greatly improved, and the combined artificial blood vessel is flexible and controllable in pipeline branch angle and high in adaptability.

Description

technical field [0001] The invention relates to the technical field of artificial blood vessels, in particular to a combined artificial blood vessel and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the common diseases that endanger human health. For severe patients, the main and auxiliary treatment is blood vessel transplantation, and the source of autologous blood vessels is limited. Therefore, a large number of artificial blood vessels are clinically required as transplant substitutes. [0003] In the manufacture of artificial blood vessels, the vast majority of foreign research is to use medical polymer materials for weaving. At the end of the 1950s and the beginning of the 1960s, China began to carry out research. At first it was woven with nylon (Nylon), but it was eliminated because of the degradation of nylon and the rupture after implantation in the living body. Dacron fiber braided artificial blood vessels are mostly ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06
CPCA61F2/06A61F2002/061A61F2240/001
Inventor 邹艳强夏家红吴杰周诚
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com