Celecoxib capsule and preparation method thereof

Abstract

The invention discloses a celecoxib capsule and a preparation method thereof, and the celecoxib capsule comprises the following materials in parts by weight: 25-80 parts of celecoxib, 19-72 parts of a blank pellet core, 0.5-2 parts of a wetting agent and 0.2-1 part of an absorption enhancer, the wetting agent is one or two of lauryl sodium sulfate, sodium lauroyl amino acid or potassium lauryl phosphate; the absorption enhancer is mannitol or / and sorbitol; according to the celecoxib capsule, the novel surfactant serves as a wetting agent, mannitol or / and sorbitol serves as the absorption enhancer, and celecoxib is good in dissolution effect, easy to absorb, high in bioavailability and good in clinical utilization value.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical engineering, in particular to a celecoxib capsule and a preparation method thereof. Background technique [0002] Celecoxib is the first specific cyclooxygenase-2 (COX-2) inhibitor developed by Searle in the United States for the treatment of osteoarthritis and rheumatoid arthritis. The most prescribed NSAID analgesic. [0003] Due to its crystal structure, celecoxib is almost insoluble in water and is an insoluble drug, and its physical and chemical properties are extremely poor in preparation performance; first, it is almost insoluble in water, and its solubility in water at 25°C is only 0.007mg / ml , the dissolution is slow in the commonly used dissolution media. If the unpulverized drug is directly filled into capsules, the unpulverized celecoxib is not easy to dissolve and disperse, so it cannot be rapidly absorbed in the gastrointestinal tract; second, the texture is light , low bulk...

AI Technical Summary

Problems solved by technology

[0005] On the other hand, micropill capsules do not require a glidant. Compared with powder-filled capsules, the weight difference is small, the fluidity is good, the drug release of the micropills is stable, and the dissolution is better. The drug adheres to the surface of the micropills and has a large specific surface area. The bioavailability is high, making celecoxib into pellets and capsules is a more scientific and reasonable method than wet granulation, but the conventional pellet preparation method is not suitable for direct celecoxib raw materials, because the commonly used preparation method The main drug and auxiliary materials need to be sprayed alternately, and organic solvents (usually ethanol) are used. The preparation process takes a long time and the process is complicated. When spraying with ethanol, it needs to be heated. This process is not safe and the dissolution effect is not good.

Images