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Algae-bacterium gel dressing and preparation method thereof

A technology of gel and gel particles, applied in bandages, absorbent pads, medical science, etc., can solve problems such as waste, wound dressings cannot deliver therapeutic substances for a long time, and chronic inflammation is difficult to heal, so as to achieve large hydrogen production and produce Hydrogen time is long, the effect of promoting wound healing

Active Publication Date: 2021-09-28
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the prior art, it is difficult to heal wounds, especially various chronic wounds that are in oxidative damage and long-term chronic inflammation.
At the same time, the existing wound dressings cannot deliver therapeutic substances for a long time, and all need to be replaced after use, resulting in waste

Method used

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  • Algae-bacterium gel dressing and preparation method thereof
  • Algae-bacterium gel dressing and preparation method thereof
  • Algae-bacterium gel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Preparation of algae-bacteria gel dressing:

[0047] Mix Chlorella, live Bacillus licheniformis and sodium alginate aqueous solution (mass concentration: 1%~4%), wherein the volume of the mixture of Chlorella, Bacillus licheniformis and sodium alginate solution is 1:1 ~1:2 between. The mixture was then injected into a 3% (w / v) calcium chloride solution to prepare a gel. In the obtained gel, the concentration of the total number of microorganisms (the concentration of the total number of algae and bacteria) was 1.4×10 8 ~8×10 8 individual / mL.

[0048] The obtained gel is transferred to a hydrophilic PTFE polytetrafluoroethylene film with a pore size of 0.1-0.22um, and a transparent and airtight waterproof polyurethane adhesive film is pasted on the gel to obtain a molded dressing.

[0049] The inner lining layer allows the gas and water to permeate the tissue in one direction and efficiently, and at the same time isolates the transmembrane diffusion of microalgae...

Embodiment 2

[0057] Mix Scenedesmus obliquus, Phaeodactylum tricornutum, live Bacillus subtilis with Poloxamer solution (mass concentration 20%~30%). The ratio is 1:6, the mixed solution of Scenedesmus oblique, Phaeodactylum tricornutum and live Bacillus subtilis (the total concentration of microorganisms is 3.5×10 8 ~8×10 8 Individuals / mL) and the volume of poloxamer solution is between 1:1~1:2. Then the mixture was left to stand to obtain a gel.

[0058] The obtained gel is transferred to a hydrophilic PTFE polytetrafluoroethylene film with a pore size of 0.1-0.22um, and a transparent and airtight waterproof polyurethane adhesive film is pasted on the gel to obtain a molded dressing.

[0059] The obtained gel was tested by the method of step (2) in Example 1, and the hydrogen production concentration was 4.2 μmol.

Embodiment 3

[0061] Mix Synechococcus, Anabaena, live Rhodospirillum rubrum with 0.5%-1% photoinitiator, 2-methylpropiophenone, gelatin-methacrylamide solution (mass concentration is 10%~30% ) and mix well, wherein the number ratio of Synechococcus and Anabaena to Rhodospirillum rubrum is 1:8, Synechococcus, Anabaena, Rhodospirillum and photoinitiator, 2-methylpropane Mixture of ketones (in which the total concentration of microorganisms is 3.5×10 8 ~8×10 8 per mL) and gelatin-methacrylamide solution in a volume ratio of 1:1. Then the mixed solution is irradiated with 405nm light for 10-30s to make the mixed solution gel, and the gel is obtained after standing still.

[0062] The obtained gel is transferred to a hydrophilic PTFE polytetrafluoroethylene film with a pore size of 0.1-0.22um, and a transparent and airtight waterproof polyurethane adhesive film is pasted on the gel to obtain a molded dressing.

[0063] The obtained gel was tested by the method of step (2) in Example 1, and t...

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Abstract

The invention discloses a simultaneous algae-bacterium gel dressing. The simultaneous algae-bacterium gel dressing comprises an airtight and transparent backing layer and gel arranged in the backing layer, and the gel is gel particles containing microalgae and live aerobic bacteria. According to the dressing, gel is used as a carrier, oxygen consumption of aerobic bacteria is used for accelerating system hypoxia, and hydrogenase activated by microalgae can release hydrogen through photosynthesis, so that chronic wound inflammation is improved, and healing is promoted. A filler of the dressing contains active microalgae and / or aerobic bacteria capable of delivering high-concentration dissolved oxygen to tissues at the same time, the dressing backing layer is a transparent and airtight film, and after the dressing is attached to a wound surface, hydrogen generated by the microalgae can efficiently permeate the tissues and improve oxidative damage and chronic inflammation of the wound surface, so that the dressing has the effects of promoting various wounds, especially, the chronic wounds, and more particularly the chronic wound of diabetes mellitus, to be repaired. The dressing adopts a local hydrogen supply technology and is convenient to carry.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to an algae-bacteria gel medical dressing. Background technique [0002] In the prior art, it is difficult to heal wound sites, especially various chronic wounds in oxidative damage and long-term chronic inflammation. At the same time, the existing wound dressings cannot deliver therapeutic substances for a long time, and all of them need to be replaced after use, resulting in waste. Contents of the invention [0003] Aiming at the above-mentioned problems in the prior art, the present invention proposes an algae-bacteria dressing for wound repair and a preparation method thereof. After the algae-bacteria symbiotic gel dressing is attached to the wound surface, it can prevent the wound from contacting the pathogens in the external environment by isolating the wound surface and the external environment; the prepared gel carrier can slowly release hydrogen gas, which prolongs the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/26A61L15/32A61L15/42A61L15/44A61L15/46
CPCA61L15/40A61L15/28A61L15/26A61L15/32A61L15/42A61L15/44A61L15/46A61L2300/412A61L2300/30C08L5/04C08L5/08C08L71/02C08L89/00
Inventor 吴锦慧陈欢欢国云飞胡一桥
Owner NANJING UNIV
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