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Hollow metal oxide microspheres and preparation method and drug sustained release application thereof

An oxide and metal technology, applied in the field of hollow metal oxide microspheres, can solve the problems of silver-based antibacterial agents, such as easy oxidative discoloration, easy aging due to light, complicated process, etc. The effect of wide application prospects

Pending Publication Date: 2021-10-12
杨洋 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Organic antibacterial agents have been used earlier, with a wide range of sources, mature technology, convenient processing, strong bactericidal power, and a wide range of antibacterial agents, but they are volatile, poor in safety, poor in heat resistance, poor in chemical stability, and prone to aging under light, which leads to drug efficacy. The time is short, easy to hydrolyze, and the service life is short, which limits its application
Compared with other antibacterial agents, the advantages of inorganic antibacterial agents are good heat resistance, wide antibacterial range, strong antibacterial power, good persistence, high safety, low toxicity, odorless and no drug resistance, such as silver-based nano Materials, such as nano-titanium dioxide and zinc oxide with light and self-cleaning functions, have the disadvantages of slow onset of action, inability to quickly kill microorganisms, complex process and high cost, and the application of different metals is also limited, such as copper-based antibacterial agents The color is darker, silver-based antibacterial agents are prone to oxidative discoloration and are expensive, while zinc and other metals have relatively poor antibacterial effects

Method used

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  • Hollow metal oxide microspheres and preparation method and drug sustained release application thereof
  • Hollow metal oxide microspheres and preparation method and drug sustained release application thereof
  • Hollow metal oxide microspheres and preparation method and drug sustained release application thereof

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preparation example Construction

[0057] Hollow metal oxide microspheres can be prepared by template method, layer coating method and other methods. In some embodiments of the present invention, a method for preparing hollow metal oxide microspheres using carbon spheres as templates is provided. The method is based on the method described in references Xiaoyong Lai, Jun Li, Brian A. Korgel, Zhenghong Dong, Zhenmin Li, FabingSu, JiangDu, and Dan Wang*.Angew.Chem.Int.Ed.2011,50,2738 Made improvements. Specifically, the method includes: dehydrating and polycondensing 130g of sucrose at 200°C to obtain carbon microspheres, taking 0.6g of carbon microspheres, adding them to 30ml 3mol / L TiCl 4 In the solution, by adjusting the adsorption temperature and adsorption time, vacuum filtration, oven drying at 80°C for 12 hours, and calcining in a muffle furnace at 500°C to obtain carrier materials with different shell structures. Under the same calcination conditions, if adsorption at room temperature is used for 6 hour...

Embodiment 1

[0068] The sucrose aqueous solution with a concentration of 1.5M was hydrothermally reacted in an autoclave at 200°C for about 130min, cooled naturally, filtered with suction, washed with water and ethanol several times, and dried in an oven at 80°C for 24h. Carbon spheres are about 3 μm in diameter.

[0069] 0.6g carbon spheres (as the preparation of TiO 2 Hollow sphere template) uniformly dispersed in 30mL 3M TiCl 4 in solution. Stir at 25°C for 2h, then filter with suction, wash with deionized water three times, and dry in an oven at 80°C for 12h. Place the obtained solid powder in a muffle furnace, raise the temperature to 500°C at 2°C / min, keep it warm for 3h, and obtain a single-shell TiO after natural cooling. 2 hollow ball. Its transmission electron microscope pictures are shown in figure 1 a.

[0070] 8 mg of prepared single-shell TiO 2 The hollow spheres were placed in a vacuum drying oven, vacuumed for 30 minutes, then 2 mL of 10 wt % methylisothiazolinone an...

Embodiment 2

[0075] The sucrose aqueous solution with a concentration of 1.5M was hydrothermally reacted in an autoclave at 200°C for about 130min, cooled naturally, filtered with suction, washed with water and ethanol several times, and dried in an oven at 80°C for 24h. Carbon spheres are about 3 μm in diameter.

[0076] Disperse 0.6g carbon sphere template evenly in 3M TiCl 4 in solution. At 40°C, stir and age for 8 hours, then filter with suction, wash with deionized water for 3 times, dry in an oven at 80°C for 12 hours, put the obtained solid powder in a muffle furnace and raise the temperature to 500°C at 2°C / min, and keep it warm for 3 hours , double-shelled TiO was obtained after natural cooling 2 hollow ball. Its transmission electron microscope pictures are shown in figure 1 b.

[0077] 8 mg of prepared double-shell TiO 2 The hollow spheres were placed in a vacuum drying oven, vacuumed for 30 minutes, then 2 mL of 10 wt % methylisothiazolinone antibacterial agent was added,...

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Abstract

The invention provides a method for preparing hollow metal oxide microspheres. The method comprises the following steps: 1) preparing carbon microspheres; 2) contacting the carbon microspheres with a solution containing metal ions so as to adsorb the metal ions to the carbon microspheres; and (3) calcining the carbon microspheres treated in the step (2) to enable the adsorbed metal ions to form the hollow metal oxide microspheres, and controlling the treatment temperature and / or time in the step (2) to obtain the single-shell or multi-shell hollow metal oxide microspheres. The invention also provides application of the hollow metal oxide microsphere as a drug carrier and a drug sustained release system comprising the hollow metal oxide microsphere. The hollow metal oxide microspheres provided by the invention can greatly prolong the effective action time of drugs and reduce the environmental toxicity of the drugs, and have wide application prospects in the aspect of antimicrobial coatings.

Description

technical field [0001] The present invention relates to hollow metal oxide microspheres. More specifically, the present invention relates to a multi-shell hollow material and its use as a carrier for a slow-release system of antibacterial drugs. Background technique [0002] There are a wide range of microorganisms (such as bacteria and molds) distributed in the natural environment, and the damage to various materials is ubiquitous. At the same time, various infectious diseases caused by microorganisms have also caused great harm to humans. After microorganisms infect the material, they will grow and reproduce in large quantities in the material when they encounter suitable growth conditions, resulting in signs of instability in the material system, such as pigment precipitation and gas generation when the pH value of the paint changes, and eventually Causes the material to fade and peel off. The use of antibacterial coatings is one of the most effective methods to achieve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G23/053A01N25/08A01N25/26A01N43/80C09D5/14
CPCC01G23/0536A01N25/08A01N43/80A01N25/26C09D5/14C01P2004/04C01P2004/34C01P2004/01
Inventor 杨洋尹伟
Owner 杨洋
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