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Continuous synthesis method of benzophenone compound

A technology of benzophenones and chemical synthesis, which is applied in the direction of preparation of organic compounds, condensation preparation of carbonyl compounds, chemical instruments and methods, etc., can solve the problems of short reaction time and good environmental protection, and achieve small footprint and high conversion The effect of high efficiency and low human resources

Active Publication Date: 2021-10-12
CHANGZHOU TRONLY ADVANCED ELECTRONICS MATERIALS CO LTD +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to provide a continuous synthesis method of benzophenone compounds to solve the problem that the existing synthesis method cannot simultaneously meet the requirements of short reaction time, good environmental protection, and industrial production.

Method used

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  • Continuous synthesis method of benzophenone compound
  • Continuous synthesis method of benzophenone compound
  • Continuous synthesis method of benzophenone compound

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] Example uses figure 1 The shown device prepares benzophenone compounds. The microchannel equipment system used is provided by Shanghai Timo Fluid Technology Co., Ltd., the model is TMP / S119-61-9 / A100, and the channel inner diameter of the microchannel reactor is 4000 μm. Synthetic methods include:

[0038] The substituted or unsubstituted benzoic acid is stored in the first raw material storage tank 10 as the first organic matter, the substituted or unsubstituted trichlorotoluene is stored in the second raw material storage tank 20 as the second organic matter, and the benzene or biphenyl Stored in the third raw material storage tank 30 as the third organic matter. Through the first feed pump 11 (P1), the second feed pump 21 (P2), the third feed pump 31 (P3), the first organic matter, the second organic matter and the third organic matter are input into the micro-mixer 40 respectively Mix to obtain a mixed solution. Then the above-mentioned mixed solution is sent to ...

Embodiment 5

[0044] The difference from Example 1 is that the molar ratio of the first organic compound, the second organic compound and the third organic compound is 1:0.95:2.1.

[0045] The conversion rate of the product is 90.71%, and the selectivity is 99.27%.

Embodiment 6

[0047] The difference from Example 1 is that the molar ratio of the first organic compound, the second organic compound and the third organic compound is 1:1.05:1.9.

[0048] The conversion rate of the product is 91.87%, and the selectivity is 98.26%.

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Abstract

The invention provides a continuous synthesis method of a benzophenone compound. The benzophenone compound has a structure as shown in a formula (I), devices adopted by the continuous synthesis method are a microreactor and a pressure control device, and the pressure control device is used for controlling the pressure in the microreactor; the continuous synthesis method comprises the following steps: inputting a first organic matter, a second organic matter and a third organic matter into the microreactor, and carrying out acylation reaction and Friedel-Crafts reaction under the action of a pressure control device to obtain the benzophenone compound, wherein the first organic matter is substituted or unsubstituted benzoic acid, the second organic matter is substituted or unsubstituted trichlorotoluene, and the third organic matter is benzene or biphenyl. Compared with a conventional reactor, the synthesis method has the advantages that the mass and heat transfer property of a reaction system can be greatly improved, the expected conversion rate can be achieved without greatly excessive reactants, meanwhile, the reaction time is shortened, the production efficiency is improved, the continuity and automation of the process are realized, and the process safety is improved.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a continuous synthesis method of benzophenone compounds. Background technique [0002] Benzophenone compounds can be used as photoinitiators, ultraviolet absorbers, spices, etc., and are widely used in photocurable coatings, inks, cosmetics, and food. [0003] The industrial production of benzophenone compounds mainly adopts the Friedel-Crafts method, using acid chloride or anhydride and benzene as raw materials, and the Friedel-Crafts reaction under the catalysis of Lewis acids such as aluminum trichloride, ferric chloride, and zinc chloride. For example, when producing benzophenone (BP), benzoyl chloride and benzene are used as raw materials, and ferric chloride is catalyzed. In order to ensure the conversion rate, the consumption of benzene needs to be more than 5 times the molar amount, and the reaction is carried out in a high-pressure reactor. 150℃~180℃, reaction time 8h~1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/60C07C63/10C07C45/46C07C49/786C07C63/04C07C49/784C07C63/331C07C63/70C07C49/813
CPCC07C51/60C07C45/46C07C63/10C07C49/786C07C63/04C07C63/331C07C49/784C07C63/70C07C49/813Y02P20/10
Inventor 钱晓春王兵魏亮陈君马培培
Owner CHANGZHOU TRONLY ADVANCED ELECTRONICS MATERIALS CO LTD
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