Bionic collagen wound dressing as well as preparation method and application thereof
A collagen and wound technology, applied in medical science, bandages, etc., can solve the problems of slow wound healing, poor bionics, etc., achieve good biocompatibility, avoid shape change, and be conducive to wound epithelial cell regeneration.
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Embodiment 1
[0043] This embodiment provides a method for preparing a bionic collagen dextral chiral structure wound dressing with repairing function, comprising the following steps:
[0044] 1. Weigh 200 mg of D-amino acid derivatives (with benzene ring as the central core, 1,4 para-position grafted with D-phenylalanine and ethylene glycol) and dissolve it in 20 ml of methanol solution;
[0045] 2. Weigh 500mg of sodium alginate and fully dissolve it in 100ml of water to form a sodium alginate solution;
[0046] 3. Add 20ml of methanol solution of D-amino acid derivatives in step 1 to 100ml of sodium alginate aqueous solution;
[0047] 4. Stir at 25°C for 3 hours; hydrogen bonds are formed between the hydroxyl group of the D-amino acid derivative and the carboxyl group of sodium alginate to obtain a sodium alginate solution physically modified by the D-amino acid derivative;
[0048] 5. The sodium alginate solution physically modified by the D-amino acid derivative in step 4 is rotary ev...
Embodiment 2
[0055] This embodiment provides a method for preparing a bionic collagen dextral chiral structure wound dressing with repairing function, comprising the following steps:
[0056] 1. Weigh 200mg of D-amino acid derivatives (with benzene ring as the central core, 1,4 para-position grafted with D-phenylalanine) and dissolve in 20ml of methanol solution;
[0057] 2. Weigh 500mg of chitosan and fully dissolve it in 100ml of water containing 1% acetic acid to form a chitosan solution;
[0058] 3. Add the methanol solution of 20ml D-amino acid derivatives in step 1 in the 100ml chitosan aqueous solution;
[0059] 4. Stir at 30°C for 3 hours; form a hydrogen bond between the carboxyl group of the D-amino acid derivative and the hydroxyl group of chitosan to obtain a physically modified chitosan solution of the D-amino acid derivative;
[0060] 5. the chitosan solution of D-amino acid derivative physical modification in step 4 is rotary evaporated and dried;
[0061] 6. Weigh 100mg o...
Embodiment 3
[0067] This embodiment provides a method for preparing a bionic collagen dextral chiral structure wound dressing with repairing function, comprising the following steps:
[0068] 1. Weigh 200 mg of D-amino acid derivatives (with benzene ring as the central core, 1,4 para-position grafted with D-phenylalanine and ethylene glycol) and dissolve it in 20 ml of methanol solution;
[0069] 2. Weigh 500mg of sodium alginate and fully dissolve it in 100ml of deionized water to form a sodium alginate solution;
[0070] 3. Add 20ml of methanol solution of D-amino acid derivatives and 2ml of concentrated hydrochloric acid in step 1 to 100ml of sodium alginate aqueous solution;
[0071] 4. Stirring at 120°C for 4 hours, an esterification reaction occurs between the hydroxyl group of the D-amino acid derivative and the carboxyl group of sodium alginate to form an ester bond, and a sodium alginate solution chemically modified by the D-amino acid derivative is obtained;
[0072] 5. The sodi...
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Abstract
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