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Porous sodium alginate nanofiber scaffold material and preparation method thereof

A sodium alginate and nanofiber technology, applied in fiber treatment, fiber chemical characteristics, pharmaceutical formulations, etc., can solve problems such as unfavorable cell growth and transfer, unfavorable gas and nutrient transport, etc., and achieve stable preparation process and good affinity. Water effect, strong water retention effect

Pending Publication Date: 2021-11-02
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The nanofiber membranes prepared by the above electrospinning technology are usually solid, which is not conducive to the transport of gas and nutrients, and is not conducive to the growth and transfer of cells inside the nanofiber scaffold.

Method used

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  • Porous sodium alginate nanofiber scaffold material and preparation method thereof
  • Porous sodium alginate nanofiber scaffold material and preparation method thereof
  • Porous sodium alginate nanofiber scaffold material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of preparation method of porous sodium alginate nanofiber support, specifically is carried out according to the following steps:

[0029] (1) Sequentially weigh 0.32g of sodium alginate powder and 1.28g of PVA powder and add them to 20ml of deionized water, and magnetically stir in a water bath at 60°C for 6 hours to completely dissolve sodium alginate and PVA to form a transparent spinning solution .

[0030] (2) Place the above spinning solution in the needle tube of the electrospinning device, adjust the voltage to 25kV, the distance from the nozzle to the receiver is 15cm, and the flow rate is 1.5ml / h. The sodium alginate composite nanofiber membrane prepared by electrospinning was dried in a constant temperature drying oven for 48 hours.

[0031] (3) The above-mentioned sodium alginate composite nanofiber membrane was placed in a 0.2M concentration of sodium borohydride methanol solution for foaming for 12 hours, after taking it out, it was repeatedly rinse...

Embodiment 2

[0034] A kind of preparation method of porous sodium alginate nanofiber support, specifically is carried out according to the following steps:

[0035] (1) Sequentially weigh 0.48g of sodium alginate powder and 1.12g of PVA powder and add them to 20ml of deionized water, and magnetically stir in a water bath at 60°C for 6 hours to completely dissolve sodium alginate and PVA to form a transparent spinning solution .

[0036] (2) The above spinning solution was placed in the needle tube of the electrospinning device, the voltage was adjusted to 27kV, the distance from the nozzle to the receiver was 17cm, and the flow rate was 1.2ml / h. The sodium alginate composite nanofiber membrane prepared by electrospinning was dried in a constant temperature drying oven for 48 hours.

[0037] (3) The above-mentioned sodium alginate composite nanofiber membrane was placed in a 0.3M sodium borohydride methanol solution for foaming for 12 hours, and after taking it out, it was repeatedly rinse...

Embodiment 3

[0040] A kind of preparation method of porous sodium alginate nanofiber support, specifically is carried out according to the following steps:

[0041] (1) Sequentially weigh 0.16g of sodium alginate powder and 1.44g of PVA powder and add them to 20ml of deionized water, and magnetically stir in a water bath at 60°C for 6 hours to completely dissolve sodium alginate and PVA to form a transparent spinning solution .

[0042] (2) The above spinning solution was placed in the needle tube of the electrospinning device, the voltage was adjusted to 19kV, the distance from the nozzle to the receiver was 15cm, and the flow rate was 1.5ml / h. The sodium alginate composite nanofiber membrane prepared by electrospinning was dried in a constant temperature drying oven for 48 hours.

[0043] (3) The above-mentioned sodium alginate composite nanofiber membrane was placed in a 0.5M concentration of sodium borohydride methanol solution for foaming for 12 hours, after taking it out, it was rep...

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Abstract

The invention discloses a porous sodium alginate nanofiber scaffold material and a preparation method thereof. The preparation method comprises the following steps of: 1, dissolving sodium alginate and polyvinyl alcohol in deionized water in proportion, and obtaining a transparent spinning solution; 2, performing electrostatic spinning on the spinning solution obtained in the step 1 to obtain a sodium alginate composite nanofiber membrane; 3, putting the sodium alginate composite nanofiber membrane obtained in the step 2 into a sodium borohydride methanol solution for foaming, washing and drying to obtain a sodium alginate nanofiber scaffold material; and 4, putting the sodium alginate nanofiber scaffold material obtained in the step 3 into a crosslinking solution for room-temperature crosslinking, cleaning and drying to obtain the porous sodium alginate nanofiber scaffold material. The scaffold material prepared by adopting the preparation method disclosed by the invention has high porosity, high specific surface area and good biocompatibility.

Description

technical field [0001] The invention relates to the field of sodium alginate nanofiber materials, in particular to a porous sodium alginate nanofiber scaffold material and a preparation method thereof. Background technique [0002] With the vigorous development of surgical technology, the research and application of various new tissue filling materials are also in-depth. Compared with autologous tissue, the newly synthesized biomaterial has unique advantages, such as no absorption in the body, no damage to the donor site, occupying the cavity and defect caused by soft tissue injury or disease, replacing and exercising or enhancing its original function. Functional materials. [0003] Alginate is a polysaccharide compound extracted from sorghum or brown seaweed kelp, which is a derivative of alginic acid. Its safety and non-toxic properties are widely used in food (as a thickener), medicine, etc. It itself contains polysaccharide components, which can provide certain nutri...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/56A61L15/24A61L15/28A61L15/42D01F8/10D01F8/18D01D5/00
CPCA61L27/48A61L27/56A61L15/24A61L15/425A61L15/28D01D5/003D01F8/18D01F8/10D01D5/0061D01D5/0015A61L2400/12A61L2430/02C08L5/04C08L29/04
Inventor 刘玉杰肖建如万维李林高欣张丹钟南哲刘航马小雨刘繁荣杨明磊姜东杰
Owner SHANGHAI CHANGZHENG HOSPITAL
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