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A long-acting antibacterial and anti-stenosis functional urethral stent and its preparation method

An anti-stenosis and functional technology, applied in other medical devices, dilators, surgery, etc., can solve the problems of poor antibacterial and anti-stenosis effects, and achieve the effects of inhibiting overgrowth, increasing the specific surface area of ​​the lumen, and inhibiting the formation of stenosis.

Active Publication Date: 2022-06-07
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Common urethral stents include other urethral stents such as silicone urethral stents, metal urethral stents, polyglycolide or polylactide urethral stents, and collagen urethral stents. These types of urethral stents disclosed in the prior art generally have antibacterial and The problem of poor anti-stenosis effect

Method used

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  • A long-acting antibacterial and anti-stenosis functional urethral stent and its preparation method
  • A long-acting antibacterial and anti-stenosis functional urethral stent and its preparation method
  • A long-acting antibacterial and anti-stenosis functional urethral stent and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] A preparation method of a long-acting antibacterial and anti-stenosis functional urethral stent, the specific steps are as follows:

[0074] (1) prepare a fabric tube;

[0075]The yarn is made into a fabric tube by a textile forming method, wherein the yarn is composed of a plurality of silk filaments with a fineness of 7tex and a medical magnesium wire with a developing function with a fineness of 7tex; It is an 8-spindle automatic braiding machine, the braiding structure adopts diamond braiding (1 / 1 interweaving), the braiding speed is 40rpm, the gear ratio is 82 / 21, and the braiding height is 25cm;

[0076] The prepared fabric tube is a tubular fabric, the radial compression modulus of the fabric tube is 0.03MPa, the elastic recovery rate is 74.68%, the circumferential expansion breaking strength is 0.03MPa, and the yarn coverage is 67.11%;

[0077] (2) Preprocessing;

[0078] Under the condition of temperature of 50°C, the fabric tube obtained in step (1) was wash...

Embodiment 2

[0098] A preparation method of a long-acting antibacterial and anti-stenosis functional urethral stent, the specific steps are as follows:

[0099] (1) prepare a fabric tube;

[0100] The yarn is made into a fabric tube by a textile forming method, wherein the yarn is composed of a plurality of polylactic acid filaments with a fineness of 20 tex and a medical tantalum wire with a developing function with a fineness of 20 tex; The knitted structure adopts weft knitted single jersey;

[0101] The prepared fabric tube is a tubular fabric, the transverse coil density is 25 wales / 5cm, the longitudinal coil density is 25 courses / 5cm, the coil length is 5mm, and the total density is 2000 coils / 25cm 2 ; The radial compression modulus of the fabric tube is 1.31MPa, the elastic recovery rate is 87.14%, the circumferential expansion breaking strength is 4.88MPa, and the yarn coverage rate is 75.32%.

[0102] (2) Preprocessing;

[0103] The fabric tube obtained in step (1) was washed w...

Embodiment 3

[0125] A preparation method of a long-acting antibacterial and anti-stenosis functional urethral stent, the specific steps are as follows:

[0126] (1) prepare a fabric tube;

[0127] The yarn is made into a fabric tube by a textile forming method, wherein the yarn is composed of a plurality of polydioxanone filaments with a fineness of 40tex and a medical silver wire with a development function of a fineness of 40tex; Forming adopts weaving process, and weaving structure adopts plain weave;

[0128] The prepared fabric tube is a tubular fabric, the warp density is 100 pieces / 10 cm, and the weft density is 100 pieces / 10 cm; the radial compression modulus of the fabric tube is 2.11MPa, the elastic recovery rate is 81.57%, and the circumferential expansion is The breaking strength is 5.79MPa, and the yarn coverage is 66.67%;

[0129] (2) Preprocessing;

[0130] The fabric tube obtained in step (1) was washed with oxalic acid solution with a concentration of 4 wt % for 40 min ...

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Abstract

The invention relates to a urethral stent with long-acting antibacterial and anti-stenosis function and a preparation method thereof. The urethral stent is a tubular structure consisting of three layers: inner, middle and outer layers; the middle layer is a fabric tube; the outer layer is a silk fibroin film carrying anti-stenosis drugs; The inner layer is an antibacterial and antifouling coating, which is composed of chitosan-nano-silica array, fluff, microvilli and antibacterial drugs; preparation method: after the yarn is made into a fabric tube by a textile forming method, respectively An antibacterial and antifouling coating is prepared on the surface, and a silk fibroin film loaded with antistenosis drugs is prepared on its outer surface to obtain a long-acting antibacterial and antistenosis functional urethral stent. The method of the invention is simple, the surface of the prepared urethral stent is smooth, and the biocompatibility is good. It not only has excellent properties such as radial compression force, circumferential expansion force, resistance to bending and torsion, and elastic recovery, but also has long-acting antibacterial properties. And anti-stenosis function, can prevent excessive deposition of urethral collagen tissue, so as to achieve the purpose of treating urethral stricture.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a long-acting antibacterial and anti-stenosis functional urethral stent and a preparation method thereof. Background technique [0002] Urethral stricture is a difficult disease in urology, mainly due to urethral scarring. At present, the main surgical methods for the treatment of urethral stricture are urethroplasty, internal urethral incision and periodic urethral dilation. However, these methods all have certain limitations. Urethroplasty is more traumatic, the urethral incision is more traumatic and the probability of restenosis is high. Periodic urethral dilation cannot fundamentally solve the problem, and it brings great pain to the patient. Implanting a stent in the urethra can effectively treat urethral stricture, and its advantage is that it has good mechanical support performance, keeps the urethra unobstructed for a long time, and enables patients to urinate normal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/04A61L31/06A61L31/08A61L31/14A61L31/16A61L31/18A61M29/02
CPCA61L31/10A61L31/14A61L31/148A61L31/16A61L31/18A61L31/088A61L31/06A61L31/048A61L31/022A61M29/02A61M2210/1089A61L2300/216A61L2300/416A61L2300/404A61L2300/606A61L2420/02A61L2420/06A61L2420/08C08L89/00C08L5/08
Inventor 李刚李露李峰段立蓉
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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