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Application of a laser-responsive molecular probe based on perfluoropentane

A technology of perfluoropentane and molecular probes, which is applied in nanotechnology for sensing, preparations for in vivo experiments, drug delivery, etc., can solve problems such as difficult detection and short transverse relaxation time, and achieve The effect of short time consumption, good effect and low preparation cost

Active Publication Date: 2022-08-05
INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

19 The biggest advantage of F is that there is no background signal interference, because there are only trace amounts of F in teeth and bones in humans or other animals 19 F (below 10 -6 M), the presence of a solid leads to 19 The transverse relaxation time of F is very short, and the signal attenuation is too fast in the process of magnetic resonance signal detection, which is difficult to detect by traditional nuclear magnetic resonance detection methods.

Method used

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  • Application of a laser-responsive molecular probe based on perfluoropentane
  • Application of a laser-responsive molecular probe based on perfluoropentane
  • Application of a laser-responsive molecular probe based on perfluoropentane

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Embodiment 1

[0032] Take 5 mL of polyvinyl alcohol aqueous solution with a mass fraction of 5%, add 200 μL of perfluoropentane (PFP), and sonicate for 30 min in an ice bath to obtain a mixed solution, slowly drop the mixed solution into 14 mL of ice water, and add it after the addition is complete. 1mL of 0.8M FeCl 3 solution, after stirring for 30 min, add 28 μL of pyrrole monomer, and continue to stir at 4 °C for 24 h to polymerize the pyrrole monomer into polypyrrole, then add 200 mg of bovine serum albumin (BSA) and continue to stir for 12 h. After the reaction is completed, the obtained The mixed product was washed with ultrapure water, then centrifuged at 2000 rpm for 10 min, repeated washing and centrifugation three times to obtain the perfluoropentane-based laser-responsive molecular probe, labeled as PFP@PPy@BSA, and the obtained The PFP@PPy@BSA was dispersed in sterile PBS for later use, and recorded as the PFP@PPy@BSA stock solution.

[0033] The schematic structural diagram of...

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Abstract

The present invention disclosed an application based on the omnin fluorine -based laser response molecular probe. The molecular probe is also used for 19 F and 129 The XE dual -core MRI detection, using the high -pass transparency and retention effect of physical tumors, the molecular probe can passively target the tumor area for lung cancer detection, and under laser irradiation, the general fluorophyl alkane changes, which ultimately leads to the end, which ultimately leads to 19 F and 129 The XE MRI signal disappears, so as to achieve laser response 19 F and 129 The XE MRI signal has changed from "opening" to "closing" state. It can confirm that magnetic resonance signals are derived from molecular probes, avoid the emergence of false positive signals, and improve the accuracy of diagnosis.

Description

technical field [0001] The invention belongs to the technical field of nuclear magnetic resonance imaging, in particular to the application of a laser-responsive molecular probe based on perfluoropentane. Background technique [0002] Magnetic Resonance Imaging (MRI) plays an important role in the diagnosis of tumors. It has the characteristics of high spatial resolution, no ionizing radiation, and good soft tissue imaging contrast. Magnetic resonance imaging commonly used in clinical practice is based on water proton imaging, which is disturbed by the background signal of normal tissues on the one hand, and suffers from the problem of low proton sensitivity on the other hand. In addition, proton contrast agents are classified into T 1 and T 2 contrast agent. T 2 Contrast agents are generally iron-based nanomaterials, which are negative contrast agents and are easily misjudged by interfering substances such as endogenous iron or blood clots in the body. T 1 The mainstr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K49/10A61K49/12A61K49/14B82Y5/00B82Y15/00B82Y40/00
CPCA61K49/1818B82Y5/00B82Y15/00B82Y40/00A61K49/10A61K49/126A61K49/143
Inventor 陈世桢丘茂松王瑞芳孙献平周欣
Owner INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS