Multifunctional artificial eye seat with adjustable microporous structure and preparation method

A microporous structure and multifunctional technology, applied in the field of biomaterials and medical implants, can solve the problems of unfavorable and rapid vascularization of microstructure and chemical composition, achieve good application value, promote vascularization, and meet the requirements of matching Effect

Active Publication Date: 2021-11-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the problem that the microstructure and chemical composition of existing prosthetic eye socket materials in the background technology are not conducive to rapid vascularization and to strengthen the prevention and control of various complications and side effects, the purpose of the present invention is to provide a microporous structure that can Adjustable, multifunctional prosthetic eye socket with infection prevention and control, inflammation regulation and high-efficiency promotion of vascularization and preparation method thereof

Method used

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  • Multifunctional artificial eye seat with adjustable microporous structure and preparation method
  • Multifunctional artificial eye seat with adjustable microporous structure and preparation method
  • Multifunctional artificial eye seat with adjustable microporous structure and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1) Mix tetraethyl orthosilicate, deionized water, and nitric acid in a molar ratio of 1:8:0.16. After stirring and hydrolyzing for 30 minutes, add calcium nitrate and zinc nitrate reagents to the mixed solution in sequence, and let the nitric acid The molar ratio of calcium, zinc nitrate, and tetraethyl orthosilicate is 2:1:2, continue to stir for 3 hours until the solution turns into a gel state, then age and dry at 60°C and 120°C for 18 hours and 36°C in sequence. hours, and then calcined at 1250°C for 3 hours, and ball-milled the obtained sauconite powder in an ethanol medium for 6 hours to obtain an ultrafine powder with a particle size below 10 μm.

[0047] 2) Weigh the ultra-fine zinc feldspar powder obtained in the above step 1) and add it to the liquid photosensitive printing resin, the mass ratio of resin to powder is 1:2, fully mix through mechanical stirring, and then use digital light processing 3D printing process Print according to the pre-designed three-d...

Embodiment 2

[0057] The preparation method is the same as in Example 1, the difference is: step 2) the internal microporous structure of the artificial eye seat is designed to be the Gyroid surface hole cell structure ( Figure 9 ), and 40% Gyroid (aperture 200 μm), 60% Gyroid (aperture 300 μm), 70% Gyroid (pore size 500 μm) and 80% Gyroid (pore size 600 μm) form a gradient structure with gradually increasing pore size.

Embodiment 3

[0059] The preparation method is the same as in Example 1, the difference is that: step 1) mix tetraethyl orthosilicate, deionized water, and nitric acid in a molar ratio of 1:8:0.16, and after continuous stirring and hydrolysis for 30 minutes, calcium nitrate, nitric acid Add copper and zinc nitrate reagents to the mixed solution in turn, and let the molar ratio of calcium nitrate, copper nitrate, zinc nitrate and ethyl orthosilicate be 1.95:0.05:1:2, and continue to stir for 5 hours until the solution turns into a condensate. gel state, then aged and dried at 60°C and 120°C for 24 hours and 60 hours in sequence, and then calcined at 1250°C for 3 hours, and the obtained copper-doped oxalite powder was ball milled in ethanol medium for 6 hours to obtain the particle size Ultrafine powder below 10μm.

[0060] In this example, the copper-doped zinc mellow feldspar powder was analyzed by ICP elements, and the content of copper in the powder was 1.11 ppm, and the molar ratio of th...

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Abstract

The invention discloses a multifunctional artificial eye seat with an adjustable microporous structure and a preparation method. The multifunctional artificial eye seat is prepared from a porous material which takes undoped or heterogeneous ion doped akermanite biological ceramic as a main component. Micro pore scales form gradient pore distribution from outside to inside, mire pores communicate with one another to form a curved-surface pore cell structure and have a plurality of radius ranges, and the pore diameters of the micro-pores are gradually increased to form a gradient structure. The preparation method comprises the following steps: mixing tetraethyl orthosilicate with deionized water and nitric acid, performing stirring and hydrolyzing, then adding calcium nitrate and zinc, performing stirring into a gel state, performing aging, performing drying, performing calcining, and performing ball-milling to obtain superfine zinc melilite powder; and adding liquid photosensitive printing resin to form slurry, performing uniform stirring and mixing, performing three-dimensional printing, removing residual slurry, and performing drying and sintering to obtain a product. The artificial eye seat keeps biological stability in vivo for a long time, and can resist bacteria, regulate inflammatory response and promote angiogenesis; the structure is accurate and adjustable, and vascular tissue can be promoted to rapidly grow into a pore channel network; and the preparation process is simple and convenient, and postoperative complications are remarkably reduced.

Description

technical field [0001] The present invention relates to a prosthetic eye seat and its preparation method in the technical field of biomaterials and medical implants, in particular to a prosthetic eye seat with antibacterial, vascularization, adjustable microporous structure and long-term stability and its preparation method. Background technique [0002] Enucleation is often used to treat irreversible eyeball damage caused by severe eye trauma, endophthalmitis, intraocular tumors, and absolute glaucoma. After the enucleation of the eyeball, it is often necessary to implant an artificial eye socket to make up for the loss of orbital volume and restore the appearance at the same time. The porous prosthetic socket provides support and guidance for the growth of blood vessels and soft tissues. After fully vascularized, the orbital stability is higher, the risk of prolapse is reduced, and the probability of postoperative infection is also greatly reduced. Therefore, the porous ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/10A61L27/54A61L27/50B33Y70/00B33Y80/00B33Y10/00A61F2/14
CPCA61L27/56A61L27/10A61L27/54A61L27/50B33Y70/00B33Y80/00B33Y10/00A61F2/141A61L2430/16A61L2300/102A61L2300/404A61L2300/41A61L2300/602A61F2240/001
Inventor 叶娟苟中入王静怡戴喜哲杨贤燕
Owner ZHEJIANG UNIV
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