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Application of plasma in preparation of drugs for improving or treating cerebral infarction and encephaledema

A cerebral infarction and plasma technology, applied in the field of medicine, can solve problems such as discomfort and aggravation of disease progression, and achieve the effect of simple production, easy disassembly and replacement, and enhanced application flexibility

Pending Publication Date: 2021-11-12
北京北卓医疗科技发展有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the past, the development of plasma therapy equipment was often limited to sterilization, tumor treatment and skin disease treatment, which required a large amount of active substances generated by plasma. When this dose of plasma is directly inhaled by the human body, it is inevitable Discomfort, and even aggravated by hypoxia

Method used

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  • Application of plasma in preparation of drugs for improving or treating cerebral infarction and encephaledema
  • Application of plasma in preparation of drugs for improving or treating cerebral infarction and encephaledema
  • Application of plasma in preparation of drugs for improving or treating cerebral infarction and encephaledema

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 a batch-type embodiment of the plasma discharge apparatus

[0043] like figure 1 Plasma apparatus illustrated embodiment provides a method of treating a neurological disease for the present embodiment of the invention, the apparatus comprising: a gas cylinder 1, the gas / plasma generator circuit controller 2 and 3, figure 1 Cylinders example of a high-purity gas tank, high purity gases stored in the tank may be helium or argon. A first cylinder 1 is connected to the gas pipe 412 / controller circuit, gas / controller circuit 2 through the second pipe 42, and high-voltage lines 43 and ground lines 44 connected to the plasma generator 3. In an embodiment of the present invention, the term "high voltage" refers to a line with respect to ground of a relatively high voltage output, not the upper limit for the applied voltage 10Kv or more high-voltage voltage. In an embodiment of the present invention, the value of the applied voltage on the high voltage is typically i...

Embodiment 2

[0058] Example 2 Plasma discharge device

[0059] Using a needle-cyclic medium blocking discharge structure, the quartz glass tube is used as a medium tube, an inner diameter of 1 mm, an outer diameter of 3 mm, and a stainless steel needle of the radius of curvature. The high voltage electrode is made from the ground electrode from the aluminum foil of the width 2 mm. The distance between the needle tip to the ground electrode and the distance of the ground electrode to the tube are 10 mm; the driving voltage is 5.6 kV, the frequency is 5000 Hz, ultrapure helium (99.99%) discharge. The apparatus of this embodiment can also be used in the experiment of Example 3.

Embodiment 3

[0060] Example 3 New use of intermittent plasma inhalation in improving cerebral infarction and cerebral edema

[0061] First, experimental materials

[0062] 1. Plasma discharge device: The plasma discharge device produced in Example 1 was applied to the interferometric intervention experiment of rat brain ischemia model.

[0063] 2. Experimental animals: Adult male SD rats, weight 200-220g, was placed in polypropylene cage after purchasing, 12h period - secretly in the environment, allowing free to take food water. Rats were randomly divided into a sham-surgical group with a random number meter (for control), the model group, and the plasma suction group, 6 in each group. The experimental process follows 3R principles to reduce the number of animals and the pain of animal use.

[0064] Second, the experiment method

[0065] 1. Making a rat brain mid arterial occlusion (MCAO) model:

[0066] Using a linear hydrotectial pulsation (MCAO model), an ischemic stroke model was construc...

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Abstract

The invention discloses application of plasma in preparation of drugs for improving or treating cerebral infarction and encephaledema, and belongs to the technical field of medicines. New application of intermittent plasma to improvement of cerebral infarction and encephaledema is found for the first time, the intermittent plasma has the advantages of uniformity, stability, contact safety and the like, and the treatment effect of diseases is improved by providing plasma inhalation intervention when cerebral arterial thrombosis is attacked; and the cerebral infarction volume of an experimental cerebral arterial thrombosis rat disease model can be obviously reduced.

Description

Technical field [0001] The present invention relates to improvement in the manufacture of plasma or treatment of cerebral infarction and brain edema medicament belongs to the technical field of medicine. Background technique [0002] Stroke is due to brain blood circulation disorders, neurological deficits lead to localized a group of diseases as the main feature, is now the first cause of death and disability in adults worldwide, and ischemic stroke is the most important stroke type, accounting for 70% -80% of all stroke, brain death is a major cause of cerebral vascular disease caused by insufficient blood supply to the brain damage caused by ischemia and nerve cells. In my country, with the population aging trend to accelerate and lifestyle changes, ischemic stroke morbidity and mortality showed an increasing trend in society and the family brought a heavy burden. Therefore, the prevention of ischemic stroke-related diseases, treatment methods and the development of health has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/44H05H1/24
CPCA61N1/44H05H1/24
Inventor 闫旭欧阳吉庭杨冰彦陈烨徐立新师忠芳
Owner 北京北卓医疗科技发展有限责任公司
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