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Artificial blood vessel and preparation method thereof

A technology of artificial blood vessel and base layer, which is applied in the field of medical devices and can solve the problems of easy cracking of the coating and blood leakage.

Pending Publication Date: 2021-11-19
ACCUPATH MEDICAL JIAXING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an artificial blood vessel and its preparation method to solve the problem that the above-mentioned coating is easy to break and cause adverse events of postoperative blood leakage

Method used

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  • Artificial blood vessel and preparation method thereof
  • Artificial blood vessel and preparation method thereof

Examples

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Effect test

example 1

[0047] The straight-tube artificial blood vessel is prepared by weaving. The material of the base layer is polyester fiber. The base layer of the prepared artificial blood vessel is treated in a water bath at 90°C and 1mol / L sodium hydroxide solution for 50 minutes, and then taken out. Wash to neutral pH and tumble dry.

[0048] To prepare biodegradable polymer materials, remove fat and fascia from fresh beef tendons, soak them in 2mol / L hydrochloric acid at room temperature for 48 hours, take them out, wash them, and add 0.5mol / L sodium hydroxide solution to neutralize them, and then soak them in 20 ℃, 0.1% pepsin for 12h. Take it out, wash it with water, cut it into a size of 0.05-0.5 cm, soak it in hydrochloric acid and enzymatically hydrolyze it once under the same conditions as above. Finally, under the monitoring of a polarized light microscope, the small pieces were ground into collagen with a diameter of 10-50 microns, and dried at 50-90° C. to constant weight.

[00...

example 2

[0052] The double-branch (Y-shaped) artificial blood vessel is prepared by weaving. The base layer is made of fiber material containing carbon-hydrogen bonds. The base layer is irradiated in a nitrogen-protected irradiation room (irradiation dose 50KGy), and then Immerse in a 30% acrylic acid solution, and squeeze the base layer with a liquid volume of 40% to 60%. Weight ratio), then the padded base layer is irradiated with electron beams at 100KGy, the grafting rate is 20%, after grafting, it is washed with 10g / L magnesium hydroxide solution, then washed with water and dried.

[0053] A gelatin solution was prepared at a concentration of 2 mg / mL, and the toughening agent was polyethylene glycol at a concentration of 0.05 mg / mL. The gelatin mixed solution was evenly applied to the base layer by piezoelectric spraying, and lasted for 5 minutes each time. After the spraying was completed, the base layer was taken out, placed in a 40°C oven for drying, and repeated coating and dr...

example 3

[0055] The artificial blood vessel was prepared by knitting. The material of the base layer was polyester fiber. First, it was treated with 2mol / L sodium hydroxide solution at 80°C for 50 minutes in a water bath, and then it was taken out, washed until the pH was neutral, and dried to shape.

[0056] Prepare porcine collagen as in Example 1, and prepare a porcine collagen solution with a concentration of 0.5 mg / mL. The plasticizer is acetyl tributyl citrate with a concentration of 0.05 mg / mL. In a closed container, pre-vacuum the basal layer, and then allow the collagen solution to flow into the artificial vessel. Take out the base layer and place it in an oven at 40-50°C for drying. Repeated coating 5 times, finally thermal crosslinking.

[0057] It should be noted that the above only exemplifies several methods for preparing artificial blood vessels, but it should be understood that in this embodiment, the previous parts of this embodiment can also be used in preparing the ...

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Abstract

The invention provides an artificial blood vessel and a preparation method thereof. The preparation method comprises the steps: providing a substrate layer; carrying out carboxylation modification on the substrate layer; coating the substrate layer subjected to carboxylation modification to form a coating layer, wherein the coating layer covers the surface of the substrate layer and fills gaps of the substrate layer; and curing the coating layer, and then forming the artificial blood vessel. The substrate layer of the artificial blood vessel is subjected to carboxylation modification before being coated, so that the hydrophilicity of the substrate layer can be improved, and a coating solution can permeate into gaps among fibers of the substrate layer to fill the gaps among the fibers of the substrate layer when the substrate layer is subsequently coated; therefore, in clinical use, the situation that an artificial blood vessel is broken due to folding, suturing and other operations, and then the adverse event of postoperative blood leakage is caused is avoided.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an artificial blood vessel and a preparation method thereof. Background technique [0002] Artificial blood vessels are mainly used to replace or repair human autologous blood vessels that are diseased or damaged due to factors such as disease and trauma, and are also used in bypass surgery. There are usually two types of artificial blood vessels: woven and non-woven, and the woven artificial blood vessels can be made of biocompatible fibers. Weaving methods include knitting, weaving, weaving, and the like. [0003] The basal layer of the artificial blood vessel is a high-porosity structure composed of interwoven fibers. This porous structure is conducive to the directional migration, proliferation and differentiation of endothelial cells and smooth muscle cells, accelerates the endothelialization of blood vessels, and avoids thrombosis and inflammatory reactions. Howev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/18A61L27/34A61L27/50A61F2/06
CPCA61L27/28A61L27/18A61L27/34A61L27/507A61L27/50A61F2/06A61L2400/18A61L2420/02A61L2420/06C08L67/00C08L89/00C08L71/02
Inventor 姚昊谷子琦马晓曼明景阙亦云
Owner ACCUPATH MEDICAL JIAXING CO LTD
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