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Dental matrix auxiliary material and preparation method thereof

A technology of matrix and excipients, applied in the field of oral care, can solve the problems of inability to continuously exert the drug effect, exposure of the active part, poor treatment effect, etc., and achieve the effects of controlling bacterial growth, ensuring long-term retention, and wide application range

Pending Publication Date: 2021-11-23
博纳格科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, for common oral diseases, such as ulcers, periodontitis, and gingivitis, traditional methods such as tablets, liquid sprays, gargles, and gels are used for treatment, which are easily affected by the patient's saliva secretion and chewing actions, resulting in The site of action (affected site) is exposed again, and the effect of the drug cannot be continuously exerted, and the therapeutic effect is poor

Method used

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  • Dental matrix auxiliary material and preparation method thereof
  • Dental matrix auxiliary material and preparation method thereof
  • Dental matrix auxiliary material and preparation method thereof

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preparation example Construction

[0069] The present invention further gives a method of preparing a dental matrix excipient, including the following steps.

[0070] Step 1, according to the proportional hydrophobic polymer, the powder material is 40 mesh sieve;

[0071] As one of the optional embodiments, the solid material is pulverized using a pulverizer, a 40 mesh screen;

[0072] Step 2, a hydrophobic polymer is placed in a stirring apparatus, and the mixture is added to the stirring apparatus, and the stirring is added to 200-250 rpm (revolution per minute), and the mixing solution A is obtained.

[0073] Alternatively, the hydrophobic polymer is placed in a laboratory kneading machine, which is adjacent to the diluent and a plasticizer, and the laboratory kneading machine is sealed, and the laboratory kneading machine is sealed and closed, at 160-165 ° C, 180-200 rpm Melting, kneading 3H, cooling, obtained a mixture A;

[0074] Step 3, according to the ratio of hydrophilic polymer, add a uniform solution A,...

Embodiment 3

[0085] Example 3 Preparation method of dental matrix excipient, in step 2, a laboratory kneading machine is selected; in step 2, the diluent is adjacent to the liquid paraffin, and the plasticizer is adjacent to the polyethylene wax, and Brazilian palm wax; Fusion, kneading, cooling under 160 ° C, 200 rpm; in step 3, the diluent is adjacent to 95% ethanol; stirring is continued at 50 ° C in a closed condition. Specific steps are as follows:

[0086] Step 1, according to the proportional hydrophobic polymer, the powder material is 40 mesh sieve;

[0087] Step 2, placing the hydrophobic polymer in the laboratory kneader, the diluent is adjacent to the liquid paraffin, the plasticizer is adjacent to the polyethylene wax, Brazilian palm wax, and the laboratory kneading machine is sealed, The melting is melted at 160 ° C, 200 rpm, kneading 3 h, cooled, and a mixture of mixture A is obtained;

[0088] Step 3, according to the ratio of hydrophilic polymer, the diluent is adjacent to 95% ...

Embodiment 4

[0091] Example 4 Preparation method of dental matrix excipient, in step 2, a laboratory kneading machine is selected; in step 2, the diluent is adjacent to liquid paraffin, and the plasticizer is adjacent to the solid paraffin; at 165 ° C, 180 rpm, melting, Kneaded, cooling; in step 3, the diluent is adjacent to glycerin, and the plasticizer is adjacent to the beeswax, phospholipid; at 60 ° C. Stir.

[0092] Specific steps are as follows:

[0093] Step 1, according to the proportional hydrophobic polymer, the powder material is 40 mesh sieve;

[0094] Step 2, placing the hydrophobic polymer in the laboratory kneader, the diluent is adjacent to liquid paraffin, and the plasticizer is adjacent to the laboratory kneading machine, and the laboratory kneading machine is closed, and the molten at 165 ° C, 180 rpm. Knead 3H, cool, resulting in a mixture A;

[0095] Step 3, according to the proportion to the peer-to-petrogen, the diluent is adjacent to glycerin, and the plasticizer is adj...

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Abstract

The invention relates to a dental matrix auxiliary material and a preparation method thereof. The dental matrix auxiliary material comprises the following raw materials in parts by weight: 30-50 parts of hydrophilic polymers, 35-55 parts of hydrophobic polymers, 8-16 parts of diluents, and 0.5-10 parts of plasticizers. The dental matrix auxiliary material is suitable for oral diseases, has certain flexibility, can be combined with other medicines to cover or wrap an affected part, meets the requirements of long-lasting adhesion, slow release, long acting and more efficient medicine utilization, can avoid dilution of medicine concentration by oral cavity saliva, has a self-dissolving property, and does not need to be removed for the second time.

Description

Technical field [0001] The present invention relates to the technical field of oral care, specifically a dental matrix materials and preparation method thereof. Background technique [0002] Pathological phenomenon of oral disease mainly refers to oral influenced by external factors, bacteria or viruses invade the gums or developmental abnormalities and other causes. Common and the high incidence of oral diseases are: gingivitis, periodontitis, oral ulcers, thrush, denture cleaning improperly can lead to oral diseases. [0003] For oral disease caused by bacteria, often depending on the severity of the different treatments. Commonly used mechanical treatment to remove plaque, supplemented with oral antibiotics, topical chlorhexidine-based treatment agent gargle. Although convenient oral antibiotic, is the most common route of administration, but the drug absorption after oral administration, is limited by the transport of the blood circulation to the disease site concentration of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K47/32A61K47/10A61K47/06A61K47/42A61K47/36A61K47/24A61K47/46A61K9/06A61K45/06A61P1/02A61P31/02
CPCA61K47/38A61K47/32A61K47/10A61K47/06A61K47/42A61K47/36A61K47/24A61K47/46A61K9/06A61K45/06A61P1/02A61P31/02
Inventor 陈辉王跃姜智旭李志军
Owner 博纳格科技(天津)有限公司
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