Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of acetophenone

A technology of acetophenone and cumene, which is applied in the field of preparation of acetophenone, can solve the problems of expensive reaction cost, high requirements for catalyst and reaction device, and achieve the effects of low reaction cost, environmental friendliness and simple operation

Pending Publication Date: 2021-12-03
黑龙江立科新材料有限公司
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has high requirements on catalysts and reaction devices, and the reaction cost is relatively expensive.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of acetophenone
  • Preparation method of acetophenone

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] The invention provides a kind of preparation method of acetophenone, comprises the following steps:

[0026] 1) Under heating conditions, oxygen is used to oxidize the alkaline solution containing cumene to obtain an oxidation reaction solution;

[0027] 2) adding the ferrous sulfate solution into the oxidation reaction solution to react to obtain acetophenone.

[0028] Above-mentioned preparation method can be represented by following reaction formula:

[0029]

[0030] The inventor speculates that this reaction has experienced the following reaction process:

[0031] In step 1), heating conditions can cause cumene to generate free radical intermediates, which can be further reacted to obtain cumene hydroperoxide after reacting with oxygen;

[0032] In step 2), ferrous sulfate can be used as a reducing agent to reduce cumene hydroperoxide, and the reduction goes through two stages. First, under the action of ferrous sulfate, cumene hydroperoxide removes a molecule...

Embodiment 1

[0051] The preparation method of present embodiment acetophenone comprises the following steps:

[0052] 1) Add cumene (1200g, 10mol) into a 2L autoclave, then add 0.3g of sodium carbonate and 100mL of water, seal and stir;

[0053] 2) Feed nitrogen into the autoclave to 1.0-1.1MPa, then heat to 110°C, feed oxygen, and open the tail gas valve, control the flow of oxygen to 0.25L / min, keep the flow for one hour, adjust the oxygen Flow rate to 0.4L / min, after continuing to react for 5h, stop the reaction to obtain the oxidation reaction solution;

[0054] 3) FeSO 4 ·7H 2 O (3336g, 12mol) was dissolved in 33.36kg of water to obtain a ferrous sulfate solution. The controlled temperature was 10-15°C and the ferrous sulfate solution was added to the oxidation reaction solution at a rate of 400g / min. After the addition was complete, continue Insulation reaction 10min;

[0055] 4) After the heat preservation is completed, the reaction solution is separated, and the organic phase i...

Embodiment 2

[0063] The preparation method of present embodiment acetophenone comprises the following steps:

[0064] 1) Add cumene (1200g, 10mol) into a 2L autoclave, then add 0.5g of sodium carbonate and 100mL of water, seal and stir;

[0065] 2) Feed nitrogen into the autoclave to 1.0-1.1MPa, then heat to 110°C, feed oxygen, and open the tail gas valve, control the flow of oxygen to 0.25L / min, keep the flow for one hour, adjust the oxygen Flow rate to 0.4L / min, after continuing to react for 5h, stop the reaction to obtain the oxidation reaction liquid;

[0066] 3) FeSO 4 ·7H 2 O (3336g, 12mol) was dissolved in 33.36kg of water to obtain a ferrous sulfate solution. The controlled temperature was 10-15°C and the ferrous sulfate solution was added to the oxidation reaction solution at a rate of 400g / min. After the addition was complete, continue Insulation reaction 10min;

[0067] 4) After the heat preservation is completed, the reaction liquid is separated, and the organic phase is an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of acetophenone, which comprises the following steps: 1) under a heating condition, carrying out oxidation treatment on an alkaline solution containing cumene by using oxygen to obtain an oxidation reaction solution; 2) adding a ferrous sulfate solution into the oxidation reaction solution for reaction to obtain acetophenone. Herein, the cumene is taken as a raw material, used auxiliary reagents such as oxygen and ferrous sulfate are cheap and easy to obtain, byproducts generated after reaction can be recycled, and expensive noble metal catalysts are not needed. The method has the advantages of high yield, good economic effect, low reaction cost, environmental friendliness and simple operation.

Description

technical field [0001] The invention belongs to the field of organic synthesis and relates to a preparation method of acetophenone. Background technique [0002] Acetophenone is an important organic synthesis intermediate, which can be used as a raw material for synthesizing perfumes, medicines and other organic synthesis. It is also a good solvent for cellulose ethers, cellulose esters and resins and a plasticizer for plastics. It can also be used as a solvent for cellulose ethers, cellulose esters, resins, preservatives, rubber, medicines, dyes, etc. in the manufacture of toilet soap and cigarettes. It has a great market demand and broad application prospects. [0003] In the traditional production process of acetophenone, it mainly uses Friedel-Crafts alkylation homogeneous reaction, that is, it is produced by reacting benzene with acetyl chloride, acetic anhydride or acetic acid under the catalysis of stoichiometric anhydrous aluminum trichloride. This method produces a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C49/78C07C45/36
CPCC07C45/36C07C49/78
Inventor 柴文玉
Owner 黑龙江立科新材料有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com