A low-pressure in-situ antibacterial and repair-promoting electrospun dressing and its preparation method

An electrospinning and in-situ technology, applied in electrospinning, textiles, papermaking, bandages, etc., can solve safety problems, secondary injury of wounds and other problems, achieve strong water absorption capacity, promote collagen proliferation, and fast spinning speed Effect

Active Publication Date: 2022-05-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned prepared electrospinning dressings all have deficiencies, such as using larger voltage (more than 10KV) to cause safety problem easily; Electrospinning solvent often selects poisonous such as dichloromethane, chloroform, acetone, hexafluoroisopropanol, Solvents with a pungent odor often require dressings to be prepared in designated equipment; the prepared electrospun dressings need to be divided into two steps for wound care. First, a professional electrospun machine is used to prepare a dressing sheet of a specified shape, and then it is used to fix the patient's wound with adhesive tape use, it is easy to cause secondary damage to the wound

Method used

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  • A low-pressure in-situ antibacterial and repair-promoting electrospun dressing and its preparation method
  • A low-pressure in-situ antibacterial and repair-promoting electrospun dressing and its preparation method
  • A low-pressure in-situ antibacterial and repair-promoting electrospun dressing and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Step 1: Weigh 5g PVB and add 200ml of hot water at 70 °C for water washing, centrifuge and dehydrate after water washing to remove the supernatant, repeat the water wash 5 times, vacuum dry at 75 °C for 8 h, grind through the sieve to obtain pre-treated PVB powder;

[0038] Step 2: Weigh 0.24g PVP powder, weigh 0.56g of PVB powder in step 1 and dissolve all of them in 5g absolute ethanol, stir for 2h to obtain a homogeneous polymer spinning solution;

[0039] Step 3: Weigh 0.2 g of blue copper peptide dissolved in 0.1 g of ultrapure water and stirred until completely dissolved, weigh 0.1 g of ice flakes and 50 mg of organic polyquaternium salt-73 dissolved in 3.65 g of absolute ethanol and stirred until completely dissolved;

[0040] Step 4: Add the entire solution in step 3 to the spinning solution configured in step 2, stir continuously until the solution is completely mixed, and the polymer solute mass is 8wt%, the blue copper peptide is 2wt, the ice flake is 1wt, and th...

Embodiment 2

[0046] Step 1: Weigh 5g PVB and add 200ml of hot water at 70 °C for water washing, centrifuge and dehydrate after water washing to remove the supernatant, repeat the water wash 3 times, dry in vacuo at 75 °C for 6h, grind through the sieve to obtain pre-treated PVB powder;

[0047] Step 2: Weigh 0.6g PVP powder, weigh 0.9g PVB powder in step 1 and dissolve all in 5g absolute ethanol, stir for 2h to give a mixed homogeneous polymer spinning solution;

[0048] Step 3: Weigh 0.1 g of blue copper peptide dissolved in 0.1 g of ultrapure water and stirred until completely dissolved, weigh 50 mg of ice flakes and 50 mg of organic polyquaternium salt-73 dissolved in 3.1 g of absolute ethanol and stirred until completely dissolved;

[0049] Step 4: Add the entire solution in step 3 to the spinning solution configured in step 2, stir continuously until the solution is completely mixed, and the spinning precursor solution of the polymer solute mass is 15wt%, the blue copper peptide is 1wt, t...

Embodiment 3

[0054] Step 1: Weigh 5g PVB and add 200ml of 75 °C hot water for water washing, centrifuge and dehydrate after water washing to remove the supernatant, repeat water washing 5 times, vacuum dry at 75 °C for 6h, grind through the sieve to obtain pretreated PVB powder;

[0055] Step 2: Weigh 0.3g PVP powder, weigh 0.7g PVB powder in step 1 all dissolved in 5g absolute ethanol, stirred for 2h to obtain a mixed homogeneous polymer spinning solution;

[0056] Step 3: Weigh 60mg of blue copper peptide dissolved in 0.1g of ultrapure water and stirred until completely dissolved, weigh 0.1g of ice flakes and 50mg of organic polyquaternium salt-73 dissolved in 3.49g of absolute ethanol and stirred until completely dissolved;

[0057] Step 4: Add the entire solution in step 3 to the spinning solution configured in step 2, stir continuously until the solution is completely mixed, and the spinning precursor solution of the polymer solute mass is 10wt%, the blue copper peptide is 0.6wt, the ice ...

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Abstract

The invention discloses a low-pressure in-situ antibacterial and repair-promoting electrospun dressing and a preparation method thereof. The method includes completely dissolving the polymers PVP and PVB with absolute ethanol, then adding absolute ethanol or ultrapure water to dissolve the functional drug solution, adding the prepared spinning precursor solution to a low-voltage portable electrospinning device, and adjusting Spinning parameters enable in situ deposition of bacteriostatic and pro-reparative dressings at the wound site. The electrospun fiber membrane prepared by the invention has good air permeability and degradability, and adopts low-voltage equipment with high safety. Azurite peptide and organic polyquaternium-73 have synergistic antibacterial effect and are not easy to produce drug resistance, and can promote wound repair. The addition of moisturizer can better keep the wound moist and will not cause secondary damage to the skin .

Description

Technical field [0001] The present invention belongs to the field of biomedical dressings, specifically relates to a low-pressure in situ bacteriostatic pro-repair electrospinning dressing and preparation method thereof. Background [0002] Acute wounds are wounds that suddenly form and heal within 4-8 weeks, and the pathological development conforms to the classic process of wound repair. Once the wound healing process is hindered by certain factors, such as ischemia, infection, dryness, etc., the wound healing process is delayed or even stagnated, eventually forming a chronic and difficult wound. The occurrence of acute wounds is often accompanied by severe trauma and bleeding, which is easy to endanger life safety, and its timely disposal and care cannot be delayed. [0003] Maintaining a good local wound environment is essential for wound healing. Studies have shown that the wet wound environment can prevent cell dehydration, stimulate cell migration and thus promote the repa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/46A61L15/44D01D5/00A61L15/20A61L15/26A61L15/32
CPCA61L15/225A61L15/46A61L15/44D01D5/003A61L15/20A61L15/26A61L15/32A61L2300/252A61L2300/208A61L2300/216A61L2300/45A61L2300/404A61L2300/412C08L39/06C08L29/14
Inventor 郑华德王妍寇昊迪黄思真
Owner SOUTH CHINA UNIV OF TECH
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